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Editor-in-Chief, Robert Amdur, MD, discusses radiation and chemotherapy programs to use prior to surgical resection of rectal cancer. The main reference for the podcast is a Topic Discussion paper published in the January 2023 issue of PRO titled "Neoadjuvant therapy in the post-German rectal trial era: making sense in the absence of consensus" (2023, Issue 1, January/February). The discussion explains the concepts driving the evolution of neoadjuvant therapy, recommended radiotherapy and chemotherapy programs, and situations where it is acceptable to observe without surgery.

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Practical Radiation Oncology associate section editor Jeffrey Brower, MD, PhD, hosts a conversation on the ASTRO clinical practice guideline for radiation therapy in Endometrial Cancer. Two of the guideline authors, Matthew Harkenrider, MD, and Paola Gehrig, MD, discuss the development of the updated guidelines and review specific questions related to the management of patients with endometrial cancer.

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Editor-in-Chief Dr. Sue Yom discusses electronic patient-reported outcomes (ePROs) with Dr. Kaitlyn Lapen, a radiation oncology resident at Memorial Sloan Kettering Cancer Center who was first author of an article describing ePRO implementation in a November 2021 article, "Development and Pilot Implementation of a Remote Monitoring System for Acute Toxicity Using Electronic Patient-Reported Outcomes for Patients Undergoing Radiation Therapy for Breast Cancer"; and Dr. Patricia Holch, Reader in Applied Health Psychology from Leeds Beckett University and Dr. Galina Velikova, Professor of Psychosocial and Medical Oncology from Leeds University and the Leeds Teaching Hospital NHS Trust, who first- and last-authored an article this month describing a randomized study of ePROs versus usual care among patients receiving pelvic radiotherapy, entitled "Online Symptom Monitoring During Pelvic Radiation Therapy: Randomized Pilot Trial of the eRAPID Intervention". We review major findings from these two publications and anticipated future developments in ePROs.

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Editor-in-Chief, Robert Amdur, MD, discusses primary radiotherapy for early-stage Non-Hodgkin’s Lymphoma of Early Stage and Indolent Histology. The discussion begins with an explanation of lymphoma classification and then reviews two papers published in PRO:"Prognostic Effect of Systemic Therapy and Radiation Therapy in Stage I Nodal Marginal Zone Lymphoma" (2023, Issue 1, January/February) and "Underutilization of Radiation Therapy in Early-stage Marginal Zone Lymphoma Negatively Impacts Overall Survival" (2016, Issue 4, July/August).

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Dr. Sue Yom, Editor in Chief, hosts Dr. Horatio "Tio" Thomas, who is completing radiation oncology residency at UCSF and is first author of an article describing an ACGME-led reform process in our January issue, "Milestones 2.0: Refining the Competency-Based Assessment of Radiation Oncology Medical Residents"; Dr. Neha Vapiwala, Professor and Vice Chair of Education in Radiation Oncology and Dean of Admissions at the University of Pennsylvania School of Medicine, who first-authored an article this month related to accreditation changes at the ACGME, entitled "The ACGME’s Recent Changes to Radiation Oncology Training Program Standards: Raising the Bar for Postgraduate Training Quality to Better Reflect Our Specialty and Better Serve Our Patients"; Dr. Anna Lee, Assistant Professor from the Department of Radiation Oncology at M.D. Anderson Cancer Center, who first authored an article this month called, "Characteristics of the ARRO Educator of the Year Award Recipients"; and Dr. Emma Fields, Associate Professor and Residency Program Director of Radiation Oncology at Virginia Commonwealth University, who co-authored an editorial this month detailing principles of "The ASTRO Workforce Statement, on behalf of the ASTRO workforce subcommittee and also acted as the coordinating author on the ACGME milestones project along with Dr. Thomas.

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The James Cancer Hospital and Ohio State Comprehensive Cancer Center FLASH research team review ultra-high dose rate radiation delivery and measurement and share insight from developing a FLASH research program. Advances in Radiation Oncology associate section editor, Ashley Cetnar, PhD, leads a discussion with Arnab Chakravarti, MD, Nilendu Gupta, PhD, Ahmet Ayan, PhD, and Jessica Fleming PhD.

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Editor-in-Chief, Robert Amdur, MD, discussed two papers that were selected for review in the PROshot literature curation article published in the November/December 2022 issue of PRO. The title of the PROshot article is "PROshot: Borderline Resectable Pancreas SBRT, Surrogate Endpoints, Axillary Dissection, Genomic Classifiers, and Spine SBRT." The two articles discussed in this podcast are: "Efficacy of Preoperative mFOLFIRINOX vs mFOLFIRINOX Plus Hypofractionated Radiotherapy for Borderline Resectable Adenocarcinoma of the Pancreas: The A021501 Phase 2 Randomized Clinical Trial" and "Mature Local Control and Reirradiation Rates Comparing Spine Stereotactic Body Radiation Therapy with Conventional Palliative External Beam Radiation Therapy."

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Dr. Sue Yom, Editor in Chief, hosts Dr. Scott Soltys, Professor of Radiation Oncology from Stanford University and outgoing Section CNS Section Editor, along with Dr. Daniel Trifiletti, Associate Professor at Mayo Clinic Florida and CNS Associate Section Editor who first-authored this month’s OncoScan, entitled "Novel Applications of Stereotactic Radiosurgery Beyond Oncology: Prospective Trials in Functional Radiosurgery," and Dr. Valentina Pinzi, Senior Assistant in the Department of Neurosurgery Radiotherapy Unit of the Neurological Institute Carlo Besta in Milan, who is the lead author of an article in this month’s issue, "Hypofractionated Radiosurgery for Large or in Critical-Site Intracranial Meningioma: Results of a Phase 2 Prospective Study."

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Practical Radiation Oncology section editor, Minsun Kim, Ph.D. of University of Washington, hosts a conversation on automated treatment planning to improve plan quality beyond human intuition. A senior author on the paper published in PRO: "Clinical acceptability of automated radiation treatment planning for head and neck cancer using the radiation planning assistant", Beth Beedle, MD, of Stanford University and the chair of the AAPM TG 308: "Clinical implementation of data-driven quality control and automated treatment planning", of University of California, San Diego, Kevin Moore, Ph.D. discuss the current status and recommendations for automated treatment planning approaches to ensure patient safety.

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Editor-in-Chief Dr. Sue Yom hosts Dr. Shankar Siva, Associate Professor and Radiation Oncologist from the Peter MacCallum Cancer Centre, Australia and the supervising author of "Cost-Effectiveness of Single- versus Multi-Fraction SABR for Pulmonary Oligometastases - The SAFRON II Trial"; Dr. David Sher, Professor at the University of Texas Southwestern Medical Center and the Red Journal's Methodology Section Editor who first-authored this month's OncoScan "The Cost-Effectiveness of Consolidative Radiation Therapy in Oligometastatic Disease: High-Value Proposition or Wishful Thinking?"; and Dr. Aisling Barry, Professor and Chair of Radiation Oncology at University College Cork and Cork University Hospital, Ireland, who first-authored "The Impact of Disease Progression on Health-Related Quality of Life Outcomes in Patients with Oligo-Metastatic Disease at 12-Months post Stereotactic Body Radiotherapy."