Dans cette 65e baladodiffusion, les Drs Luc Lanthier et Michaël Mayette discutent de prophylaxie d’ulcère de stress chez les sujets sous ventilation mécanique, en plus de réviser la littérature médicale de juillet et août 2024.

Quiz clinique (3 min 00), présentation principale (3 min 25), critique (20 min 44), autres articles (27 min 10), réponse au quiz clinique (33 min 11)

Cook D, Deane A, Lauzier F, Zytaruk N, Guyatt G, Saunders L, et al; REVISE Investigators. Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation. N Engl J Med. 2024;391(1):9-20. PubMed PMID : 38875111.

Gao Y, Jiang L, Pan Y, Chen W, Jing J, Wang C, et al; INSPIRES Investigators. Immediate- or Delayed-Intensive Statin in Acute Cerebral Ischemia: The INSPIRES Randomized Clinical Trial. JAMA Neurol. 2024;81(7):741-751. PubMed PMID: 38805216.

Marcus MD, Link MS. Omega-3 Fatty Acids and Arrhythmias. Circulation. 2024;150(6):488-503. PubMed PMID: 39102482.

Valgimigli M, Hong SJ, Gragnano F, Chalkou K, Franzone A, da Costa BR, et al. De-escalation to ticagrelor monotherapy versus 12 months of dual antiplatelet therapy in patients with and without acute coronary syndromes: a systematic review and individual patient-level meta-analysis of randomised trials. Lancet. 2024;404(10456):937-48. PubMed PMID: 39226909.

Brown SM. Uncertain Answers – Proton-Pump Inhibition in the ICU. N Engl J Med. 2024;391(1):78-9. PubMed PMID: 38875100.

Wang Y, Parpia S, Ge L, Heels-Ansdell D, Lai H, Esfahani MA, et al. Proton-Pump Inhibitors to Prevent Gastrointestinal Bleeding – An Updated Meta-Analysis. NEJM Evid. 2024;3(7):EVIDoa2400134. PubMed PMID: 38874580.

MacLaren R, Dionne JC, Granholm A, Alhazzani W, Szumita PM, Olsen K, et al. Society of Critical Care Medicine and American Society of Health-System Pharmacists Guideline for the Prevention of Stress-Related Gastrointestinal Bleeding in Critically Ill Adults. Crit Care Med. 2024;52(8):e421-e30. PubMed PMID: 39007578.

Krag M, Marker S, Perner A, Wetterslev J, Wise MP, Schefold JC, et al. Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU. N Engl J Med. 2018;379(23):2199-208. PubMed PMID: 30354950.

Australian PIft, New Zealand Intensive Care Society Clinical Trials Group AHSCCSCN, the Irish Critical Care Trials G, Young PJ, Bagshaw SM, Forbes AB, et al. Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial. JAMA. 2020;323(7):616-26. PubMed PMID: 31950977.

Liu J, Li Y, Ge J, Yan X, Zhang H, Zheng X, et al. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial. Lancet. 2024;404(10449):245-55. PubMed PMID: 38945140.

Lu S, Kato T, Dong X, Ahn MJ, Quang LV, Soparattanapaisarn N, et al. Osimertinib after Chemoradiotherapy in Stage III EGFR-Mutated NSCLC. N Engl J Med. 2024;391(7):585-97. PubMed PMID: 38828946.

Landoni G, Monaco F, Ti LK, Baiardo Redaelli M, Bradic N, Comis M, et al. A Randomized Trial of Intravenous Amino Acids for Kidney Protection. N Engl J Med. 2024;391(8):687-98. PubMed PMID: 38865168.

Miyauchi K, Iwata H, Nishizaki Y, Inoue T, Hirayama A, Kimura K, et al. Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy-Statin and Eicosapentaenoic Acid (RESPECT-EPA). Circulation. 2024;150(6):425-34. PubMed PMID: 38873793.

EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). J Hepatol. 2024;81(3):492-542. PubMed PMID: 38851997.

Callum J, Skubas NJ, Bathla A, Keshavarz H, Clark EG, Rochwerg B, et al. Use of Intravenous Albumin: A Guideline From the International Collaboration for Transfusion Medicine Guidelines. Chest. 2024;166(2):321-38. PubMed PMID: 38447639.

Sharma R, Kouranos V, Cooper LT, Metra M, Ristic A, Heidecker B, et al. Management of cardiac sarcoidosis. Eur Heart J. 2024;45(30):2697-726. PubMed PMID: 38923509.

Umpierrez GE, Davis GM, ElSayed NA, Fadini GP, Galindo RJ, Hirsch IB, et al. Hyperglycemic Crises in Adults With Diabetes: A Consensus Report. Diabetes Care. 2024;47(8):1257-75. PubMed PMID: 39052901.

Vinter N, Cordsen P, Johnsen SP, Staerk L, Benjamin EJ, Frost L, Trinquart L. Temporal trends in lifetime risks of atrial fibrillation and its complications between 2000 and 2022: Danish, nationwide, population based cohort study. BMJ. 2024;385:e077209. PubMed PMID: 38631726.