Dans cette 72e baladodiffusion, les Drs Alexandre Mutchmore et Dusanka Grbic discutent du sémaglutide comme traitement de la stéatohépatite liée à une dysfonction métabolique, en plus de réviser la littérature médicale de mai et juin 2025.

Quiz clinique (3 min 33), présentation principale (4 min 12), critique (29 min 25), retour sur le cas clinique (36 min 29), autres articles (39 min 00), réponse au quiz clinique (43 min 39)

Sanyal AJ, Newsome PN, Kliers I, Ostergaard LH, Long MT, Kjaer MS, et al. Phase 3 Trial of Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis. N Engl J Med. 2025;392(21):2089-99. PubMed PMID: 40305708.

Simon TG. Semaglutide for Metabolic Dysfunction-Associated Steatohepatitis. N Engl J Med. 2025;392(21):2160-1. PubMed PMID: 40466070.

Harrison SA, Bedossa P, Guy CD, Schattenberg JM, Loomba R, Taub R, et al. A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis. N Engl J Med. 2024;390(6):497-509. PubMed PMID: 38324483.

Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, Abdelmalek MF, Caldwell S, Barb D, et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023;77(5):1797-835. PubMed PMID: 36727674.

EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). J Hepatol. 2024;81(3):492-542. PubMed PMID: 38851997.

Israelsen M, Francque S, Tsochatzis EA, Krag A. Steatotic liver disease. Lancet. 2024;404(10464):1761-1778. PubMed PMID: 39488409.

Sanyal AJ, Bedossa P, Fraessdorf M, Neff GW, Lawitz E, Bugianesi E, et al 1404-0043 Trial Investigators. A Phase 2 Randomized Trial of Survodutide in MASH and Fibrosis. N Engl J Med. 2024;391(4):311-319. PubMed PMID: 38847460.

Loomba R, Hartman ML, Lawitz EJ, Vuppalanchi R, Boursier J, Bugianesi E, et al; SYNERGY-NASH Investigators. Tirzepatide for Metabolic Dysfunction-Associated Steatohepatitis with Liver Fibrosis. N Engl J Med. 2024;391(4):299-310. PubMed PMID: 38856224.

Lin J, Huang Y, Xu B, Gu X, Huang J, Sun J, et al. Effect of dapagliflozin on metabolic dysfunction-associated steatohepatitis: multicentre, double blind, randomised, placebo controlled trial. BMJ. 2025;389:e083735. PubMed PMID: 40467095.

Humbert M, McLaughlin VV, Badesch DB, Ghofrani HA, Gibbs JSR, Gomberg-Maitland M, et al. Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death. N Engl J Med. 2025;392(20):1987-2000. PubMed PMID: 40167274.

Bonaca MP, Catarig AM, Houlind K, Ludvik B, Nordanstig J, Ramesh CK, et al. Semaglutide and walking capacity in people with symptomatic peripheral artery disease and type 2 diabetes (STRIDE): a phase 3b, double-blind, randomised, placebo-controlled trial. Lancet. 2025;405(10489):1580-93. PubMed PMID: 40169145.

Blockmans D, Penn SK, Setty AR, Schmidt WA, Rubbert-Roth A, Hauge EM, et al. A Phase 3 Trial of Upadacitinib for Giant-Cell Arteritis. N Engl J Med. 2025;392(20):2013-24. PubMed PMID: 40174237.

Laffin LJ, Kopjar B, Melgaard C, Wolski K, Ibbitson J, Bhikam S, et al. Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension. N Engl J Med. 2025;392(18):1813-23. PubMed PMID: 40267417.

Garrison SR, Bakal JA, Kolber MR, Korownyk CS, Green LA, Kirkwood JEM, et al. Antihypertensive Medication Timing and Cardiovascular Events and Death: The BedMed Randomized Clinical Trial. JAMA. 2025;333(23):2061-72. PubMed PMID: 40354045.

Herrmann JJ, Brunner-La Rocca HP, Baltussen L, Beckers-Wesche F, Bekkers S, Bellersen L, et al. Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial. Nat Med. 2025;31(6):2062-8. PubMed PMID: 40159556.

Richeldi L, Azuma A, Cottin V, Kreuter M, Maher TM, Martinez FJ, et al. Nerandomilast in Patients with Idiopathic Pulmonary Fibrosis. N Engl J Med. 2025;392(22):2193-202. PubMed PMID: 40387033.

Maher TM, Assassi S, Azuma A, Cottin V, Hoffmann-Vold AM, Kreuter M, et al. Nerandomilast in Patients with Progressive Pulmonary Fibrosis. N Engl J Med. 2025;392(22):2203-14. PubMed PMID: 40388329.

Lee CJ, Ihm SH, Shin DH, Jeong JO, Kim JH, Chun KH, et al. Spironolactone vs Amiloride for Resistant Hypertension: A Randomized Clinical Trial. JAMA. 2025;333(23):2073-82. PubMed PMID: 40366680.

Goupil R, Tsuyuki RT, Santesso N, Terenzi KA, Habert J, Cheng G, et al. Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care. CMAJ. 2025;197(20):E549-E64. PubMed PMID: 40419299

Tobe SW, Bajaj HS, Tangri N, Jain R, Pham T, Beaudin V, et al. Chronic Kidney Disease in Diabetes: A Clinical Practice Guideline. Can J Diabetes. 2025;49(2):73-86. PubMed PMID: 40382193.

Mir H, Eisenberg MJ, Benowitz NL, Cowley E, Heshmati J, Jha P, et al. Canadian Cardiovascular Society Clinical Practice Update on Contemporary Approaches to Smoking Cessation. Can J Cardiol. 2025;41(5):797-812. PubMed PMID: 40340054.

Osiowy C, Alvarez F, Coffin CS, Cooper CL, Fung SK, Ko HH, et al. The management of chronic hepatitis B: 2025 Guidelines update from the Canadian Association for the Study of the Liver and Association of Medical Microbiology and Infectious Disease Canada. Canadian Liver Journal. 2025;8(2):368-401. 

Rao SV, O’Donoghue ML, Ruel M, Rab T, Tamis-Holland JE, Alexander JH, et al. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2025;85(22):2135-237. PubMed PMID: 40013746.

Rubin DT, Ananthakrishnan AN, Siegel CA, Barnes EL, Long MD. ACG Clinical Guideline Update: Ulcerative Colitis in Adults. Am J Gastroenterol. 2025;120(6):1187-224. 

Lichtenstein GR, Loftus EV, Afzali A, Long MD, Barnes EL, Isaacs KL, et al. ACG Clinical Guideline: Management of Crohn’s Disease in Adults. Am J Gastroenterol. 2025;120(6):1225-64.

Goupil R, Tsuyuki RT, Santesso N, Terenzi KA, Habert J, Cheng G, et al. Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care. CMAJ. 2025;197(20):E549-E64. PubMed PMID: 40419299

Dans cette 71e baladodiffusion, les Drs Luc Lanthier et Geneviève LeTemplier discutent du traitement de la maladie thromboembolique paranéoplasique, en plus de réviser la littérature médicale d’avril 2025.

Quiz clinique (2 min 04), présentation principale (2 min 29), critique (25 min 44), retour sur le cas clinique (31 min 15), autres articles (32 min 35), réponse au quiz clinique (35 min 15)

Mahe I, Carrier M, Mayeur D, Chidiac J, Vicaut E, Falvo N, et al. Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism. N Engl J Med. 2025;392(14):1363-73. PubMed PMID: 40162636.

Noble S. Cancer-Associated Venous Thromboembolism – Beyond 6 Months. N Engl J Med. 2025;392(14):1439-40. PubMed PMID: 40162659.

Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, et al; Randomized Comparison of Low-Molecular-Weight Heparin versus Oral Anticoagulant Therapy for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer (CLOT) Investigators. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med. 2003;349(2):146-53. PubMed PMID: 12853587.

Raskob GE, van Es N, Verhamme P, Carrier M, Di Nisio M, Garcia D, et al; Hokusai VTE Cancer Investigators. Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism. N Engl J Med. 2018;378(7):615-624. PubMed PMID: 29231094.

Agnelli G, Becattini C, Meyer G, Munoz A, Huisman MV, Connors JM, et al. Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer. N Engl J Med. 2020;382(17):1599-607. PubMed PMID: 32233112.

Agnelli G, Buller HR, Cohen A, Curto M, Gallus AS, Johnson M, Porcari A, Raskob GE, Weitz JI; AMPLIFY-EXT Investigators. Apixaban for extended treatment of venous thromboembolism. N Engl J Med. 2013;368(8):699-708. PubMed PMID: 23216615.

Weitz JI, Lensing AWA, Prins MH, Bauersachs R, Beyer-Westendorf J, Bounameaux H, et al; EINSTEIN CHOICE Investigators. Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism. N Engl J Med. 2017;376(13):1211-1222. PubMed PMID: 28316279.

Lyman GH, Carrier M, Ay C, Di Nisio M, Hicks LK, Khorana AA, et al. American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer. Blood Adv. 2021;5(4):927-974. PubMed PMID: 33570602.

Key NS, Khorana AA, Kuderer NM, Bohlke K, Lee AYY, Arcelus JI, et al. Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Guideline Update. J Clin Oncol. 2023;41(16):3063-3071. PubMed PMID: 37075273.

Stevens SM, Woller SC, Baumann Kreuziger L, Bounameaux H, Doerschug K, Geersing GJ, et al. Executive Summary: Antithrombotic Therapy for VTE Disease: Second Update of the CHEST Guideline and Expert Panel Report. Chest. 2021;160(6):2247-2259. PubMed PMID: 34352279.

Kelley CF, Acevedo-Quinones M, Agwu AL, Avihingsanon A, Benson P, Blumenthal J, et al. Twice-Yearly Lenacapavir for HIV Prevention in Men and Gender-Diverse Persons. N Engl J Med. 2025;392(13):1261-76. PubMed PMID: 39602624.

Choi KH, Park YH, Lee JY, Jeong JO, Kim CJ, Yun KH, et al. Efficacy and safety of clopidogrel versus aspirin monotherapy in patients at high risk of subsequent cardiovascular event after percutaneous coronary intervention (SMART-CHOICE 3): a randomised, open-label, multicentre trial. Lancet. 2025;405(10486):1252-63. PubMed PMID: 40174599.

Raposeiras-Roubin S, Amat-Santos IJ, Rossello X, Gonzalez Ferreiro R, Gonzalez Bermudez I, Lopez Otero D, et al. Dapagliflozin in Patients Undergoing Transcatheter Aortic-Valve Implantation. N Engl J Med. 2025;392(14):1396-405. PubMed PMID: 40162639.

Yan S, Zhou Y, Lansberg MG, Liebeskind DS, Yuan C, Yu H, et al. Alteplase for Posterior Circulation Ischemic Stroke at 4.5 to 24 Hours. N Engl J Med. 2025;392(13):1288-96. PubMed PMID: 40174223.

Monto AS, Kuhlbusch K, Bernasconi C, Cao B, Cohen HA, Graham E, et al. Efficacy of Baloxavir Treatment in Preventing Transmission of Influenza. N Engl J Med. 2025;392(16):1582-1593. PubMed PMID: 40267424.

Thouvenot E, Laplaud D, Lebrun-Frenay C, Derache N, Le Page E, Maillart E, et al; D-Lay MS Investigators. High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Randomized Clinical Trial. JAMA. 2025;333(16):1413-1422. PubMed PMID: 40063041.

Rao SV, O’Donoghue ML, Ruel M, Rab T, Tamis-Holland JE, Alexander JH, et al. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2025;151(13):e771-e862. PubMed PMID: 40014670.

Sinha SS, Morrow DA, Kapur NK, Kataria R, Roswell RO. 2025 Concise Clinical Guidance: An ACC Expert Consensus Statement on the Evaluation and Management of Cardiogenic Shock: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2025;85(16):1618-41. PubMed PMID: 40100174.

DeSimone DC, Garrigos ZE, Marx GE, Tattevin P, Hasse B, McCormick DW, et al. Blood Culture-Negative Endocarditis: A Scientific Statement From the American Heart Association: Endorsed by the International Society for Cardiovascular Infectious Diseases. J Am Heart Assoc. 2025;14(8):e040218. PubMed PMID: 40094211.

Hernandez P, Bosse Y, Bush P, Chapman KR, Maltais F, Penz ED, et al. Alpha-1-Antitrypsin Deficiency Targeted Testing and Augmentation Therapy: A Canadian Thoracic Society Meta-Analysis and Clinical Practice Guideline. Chest. 2025;167(4):1044-63. PubMed PMID: 39880301.

Vasan RS, Enserro DM, Beiser AS, Xanthakis V. Lifetime Risk of Heart Failure Among Participants in the Framingham Study. J Am Coll Cardiol. 2022;79(3):250-263. PubMed PMID: 35057911.

Dans cette 70e baladodiffusion, les Drs Alexandre Mutchmore et Mathieu Labossière discutent de sémaglutide oral pour la prévention des événements cardiovasculaire chez les personnes avec diabète de type 2, en plus de réviser la littérature médicale de mars 2025.

Quiz clinique (1 min 26), présentation principale (2 min 17), critique (21 min 51), retour sur le cas clinique (29 min 26), autres articles (32 min 34), réponse au quiz clinique (38 min 38)

McGuire DK, Marx N, Mulvagh SL, Deanfield JE, Inzucchi SE, Pop-Busui R, et al. Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes. N Engl J Med. 2025. Epub 2025/03/31 21:17. doi: 10.1056/NEJMoa2501006. PubMed PMID: 40162642.

NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants. Lancet. 2024;404(10467):2077-2093. PubMed PMID: 39549716.

Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jódar E, Leiter LA, et al; SUSTAIN-6 Investigators. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2016;375(19):1834-1844. PubMed PMID: 27633186.

Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR, et al; PIONEER 6 Investigators. Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. N Engl J Med. 2019 ;381(9):841-851. PubMed PMID: 31185157. 

Bi Y, Li M, Liu Y, Li T, Lu J, Duan P, et al. Intensive Blood-Pressure Control in Patients with Type 2 Diabetes. N Engl J Med. 2025;392(12):1155-67. PubMed PMID: 39555827.

Couturaud F, Schmidt J, Sanchez O, Ballerie A, Sevestre MA, Meneveau N, et al. Extended treatment of venous thromboembolism with reduced-dose versus full-dose direct oral anticoagulants in patients at high risk of recurrence: a non-inferiority, multicentre, randomised, open-label, blinded endpoint trial. Lancet. 2025;405(10480):725-35. PubMed PMID: 40023651.

Vodstrcil LA, Plummer EL, Fairley CK, Hocking JS, Law MG, Petoumenos K, et al. Male-Partner Treatment to Prevent Recurrence of Bacterial Vaginosis. N Engl J Med. 2025;392(10):947-57. PubMed PMID: 40043236.

Veltkamp R, Korompoki E, Harvey KH, Harvey ER, Fiessler C, Malzahn U, et al. Direct oral anticoagulants versus no anticoagulation for the prevention of stroke in survivors of intracerebral haemorrhage with atrial fibrillation (PRESTIGE-AF): a multicentre, open-label, randomised, phase 3 trial. Lancet. 2025;405(10482):927-36. PubMed PMID: 40023176.

Advani SD, Thaden JT, Perez R, Stair SL, Lee UJ, Siddiqui NY. State-of-the-Art Review: Recurrent Uncomplicated Urinary Tract Infections in Women. Clin Infect Dis. 2025;80(3):e31-e42. PubMed PMID: 40095960.

European Association for the Study of the Liver. EASL Clinical Practice Guidelines on haemochromatosis. J Hepatol. 2022;77(2):479-502. PubMed PMID: 35662478.

Prabhu A, Cargill T, Roberts N, Ryan JD. Systematic Review of the Clinical Outcomes of Iron Reduction in Hereditary Hemochromatosis. Hepatology. 2020 Oct;72(4):1469-1482. PubMed PMID: 32500577.

Dans cette 69e baladodiffusion, les Drs Luc Lanthier et Alexandre Mutchmore discutent de remplacement valvulaire aortique percutané chez les sujets avec sténose aortique sévère asymptomatique, en plus de réviser la littérature médicale de janvier et février 2025.

Quiz clinique (2 min 25), présentation principale (2 min 50), critique (31 min 59), retour sur le cas clinique (45 min 38), autres articles (46 min 23), réponse au quiz clinique (49 min 40)

Genereux P, Schwartz A, Oldemeyer JB, Pibarot P, Cohen DJ, Blanke P, et al. Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis. N Engl J Med. 2025;392(3):217-27. PubMed PMID: 39466903.

Rubino F, Cummings DE, Eckel RH, Cohen RV, Wilding JPH, Brown WA, et al. Definition and diagnostic criteria of clinical obesity. Lancet Diabetes Endocrinol. 2025;13(3):221-62. PubMed PMID: 39824205.

Blankenberg S. Asymptomatic Severe Aortic-Valve Stenosis – To Wait or Not to Wait. N Engl J Med. 2025;392(3):278-9. PubMed PMID: 39813648.

Kang DH, Park SJ, Lee SA, Lee S, Kim DH, Kim HK, et al. Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis. N Engl J Med. 2020;382(2):111-9. PubMed PMID: 31733181.

Banovic M, Putnik S, Penicka M, Doros G, Deja MA, Kockova R, et al. Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis: The AVATAR Trial. Circulation. 2022;145(9):648-58. PubMed PMID: 34779220.

Genereux P, Banovic M, Kang DH, Giustino G, Prendergast BD, Lindman BR, et al. Aortic Valve Replacement vs Clinical Surveillance in Asymptomatic Severe Aortic Stenosis: A Systematic Review and Meta-Analysis. J Am Coll Cardiol. 2025;85(9):912-22. PubMed PMID: 39641732.

Loganath K, Craig NJ, Everett RJ, Bing R, Tsampasian V, Molek P, et al. Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis: The EVOLVED Randomized Clinical Trial. JAMA. 2025;333(3):213-21. PubMed PMID: 39466640.

Vahanian A, Beyersdorf F, Praz F, Milojevic M, Baldus S, Bauersachs J, et al. 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2022;43(7):561-632. PubMed PMID: 34453165.

Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP, 3rd, et al. 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2021;77(4):450-500. PubMed PMID: 33342587.

Packer M, Zile MR, Kramer CM, Baum SJ, Litwin SE, Menon V, et al. Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity. N Engl J Med. 2025;392(5):427-37. PubMed PMID: 39555826.

Feldman WB, Suissa S, Kesselheim AS, Avorn J, Russo M, Schneeweiss S, et al. Comparative effectiveness and safety of single inhaler triple therapies for chronic obstructive pulmonary disease: new user cohort study. BMJ. 2024;387:e080409. PubMed PMID: 39797646.

Piccini JP, Patel MR, Steffel J, Ferdinand K, Van Gelder IC, Russo AM, et al. Asundexian versus Apixaban in Patients with Atrial Fibrillation. N Engl J Med. 2025;392(1):23-32. PubMed PMID: 39225267.

Ruff CT, Patel SM, Giugliano RP, Morrow DA, Hug B, Kuder JF, et al. Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation. N Engl J Med. 2025;392(4):361-71. PubMed PMID: 39842011.

Ayus JC, Moritz ML, Fuentes NA, Mejia JR, Alfonso JM, Shin S, et al. Correction Rates and Clinical Outcomes in Hospitalized Adults With Severe Hyponatremia: A Systematic Review and Meta-Analysis. JAMA Intern Med. 2025;185(1):38-51. PubMed PMID: 39556338.

Jolly SS, d’Entremont MA, Lee SF, Mian R, Tyrwhitt J, Kedev S, et al. Colchicine in Acute Myocardial Infarction. N Engl J Med. 2025;392(7):633-42. PubMed PMID: 39555823.

Sapp JL, Tang ASL, Parkash R, Stevenson WG, Healey JS, Gula LJ, et al. Catheter Ablation or Antiarrhythmic Drugs for Ventricular Tachycardia. N Engl J Med. 2025;392(8):737-47. PubMed PMID: 39555820.

Group E-KC, Herrington WG, Staplin N, Agrawal N, Wanner C, Green JB, et al. Long-Term Effects of Empagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2025;392(8):777-87. PubMed PMID: 39453837.

Fiorella D, Monteith SJ, Hanel R, Atchie B, Boo S, McTaggart RA, et al. Embolization of the Middle Meningeal Artery for Chronic Subdural Hematoma. N Engl J Med. 2025;392(9):855-64. PubMed PMID: 39565980.

American Diabetes Association Professional Practice C. Summary of Revisions: Standards of Care in Diabetes-2025. Diabetes Care. 2025;48(1 Suppl 1):S6-S13. PubMed PMID: 39651984.

Saukkonen JJ, Duarte R, Munsiff SS, Winston CA, Mammen MJ, Abubakar I, et al. Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis: An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline. Am J Respir Crit Care Med. 2025;211(1):15-33. 

Gandhi RT, Landovitz RJ, Sax PE, Smith DM, Springer SA, Gunthard HF, et al. Antiretroviral Drugs for Treatment and Prevention of HIV in Adults: 2024 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2025;333(7):609-28. PubMed PMID: 39616604.

Davis JPE, Lim JK, Francis FF, Ahn J. AGA Clinical Practice Update on Management of Portal Vein Thrombosis in Patients With Cirrhosis: Expert Review. Gastroenterology. 2025;168(2):396-404. PubMed PMID: 39708000.

Drazner MH, Bozkurt B, Cooper LT, Aggarwal NR, Basso C, et al. 2024 ACC Expert Consensus Decision Pathway on Strategies and Criteria for the Diagnosis and Management of Myocarditis: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2025;85(4):391-431. PubMed PMID: 39665703.

Spooner MT, Messe SR, Chaturvedi S, Do MM, Gluckman TJ, et al. 2024 ACC Expert Consensus Decision Pathway on Practical Approaches for Arrhythmia Monitoring After Stroke: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2025;85(6):657-81. PubMed PMID: 39692645.

Rockey DC, Altayar O, Falck-Ytter Y, Kalmaz D. AGA Technical Review on Gastrointestinal Evaluation of Iron Deficiency Anemia. Gastroenterology. 2020 Sep;159(3):1097-1119. PubMed PMID: 32828801.

Dans cette 68e baladodiffusion, les Drs Luc Lanthier et Alex Carignan discutent de durée d’antibiothérapie pour les bactériémies, en plus de réviser la littérature médicale de novembre et décembre 2024.

Quiz clinique (2 min 15), présentation principale (2 min 49), critique (20 min 19), retour sur le cas clinique (26 min 26), autres articles (28 min 25), réponse au quiz clinique (33 min 18)

BALANCE Investigators, for the Canadian Critical Care Trials Group, the Association of Medical Microbiology and Infectious Disease Canada Clinical Research Network, the Australian and New Zealand Intensive Care Society Clinical Trials Group, and the Australasian Society for Infectious Diseases Clinical Research Network; Daneman N, Rishu A, Pinto R, Rogers BA, Shehabi Y, Parke R, et al. Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections. N Engl J Med. 2024 Nov 20. doi: 10.1056/NEJMoa2404991. PubMed PMID: 39565030.

Yahav D, Franceschini E, Koppel F, Turjeman A, Babich T, Bitterman R, et al; Bacteremia Duration Study Group. Seven Versus 14 Days of Antibiotic Therapy for Uncomplicated Gram-negative Bacteremia: A Noninferiority Randomized Controlled Trial. Clin Infect Dis. 2019;69(7):1091-1098. PubMed PMID: 30535100.

von Dach E, Albrich WC, Brunel AS, Prendki V, Cuvelier C, Flury D, et al. Effect of C-Reactive Protein-Guided Antibiotic Treatment Duration, 7-Day Treatment, or 14-Day Treatment on 30-Day Clinical Failure Rate in Patients With Uncomplicated Gram-Negative Bacteremia: A Randomized Clinical Trial. JAMA. 2020;323(21):2160-2169. PubMed PMID: 32484534.

Molina J, Montero-Mateos E, Praena-Segovia J, León-Jiménez E, Natera C, López-Cortés LE, et al; SHORTEN trial team. Seven-versus 14-day course of antibiotics for the treatment of bloodstream infections by Enterobacterales: a randomized, controlled trial. Clin Microbiol Infect. 2022;28(4):550-557. PubMed PMID: 34508886.

Werring DJ, Dehbi HM, Ahmed N, Arram L, Best JG, Balogun M, et al. Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial. Lancet. 2024:404(10464);1731-41. PubMed PMID: 39491870.

Anker SD, Friede T, von Bardeleben RS, Butler J, Khan MS, Diek M, et al. Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation. N Engl J Med. 2024;391(19):1799-809. PubMed PMID: 39216092.

Cho MS, Kang DY, Ahn JM, Yun SC, Oh YS, Lee CH, et al. Edoxaban Antithrombotic Therapy for Atrial Fibrillation and Stable Coronary Artery Disease. N Engl J Med. 2024;391(22):2075-86. PubMed PMID: 39225258.

Kang DY, Lee SH, Lee SW, Lee CH, Kim C, Jang JY, et al. Aspirin Monotherapy vs No Antiplatelet Therapy in Stable Patients With Coronary Stents Undergoing Low-to-Intermediate Risk Noncardiac Surgery. J Am Coll Cardiol. 2024;84(24):2380-9. PubMed PMID: 39217573.

Tan J, Zhu R, Li Y, Wang L, Liao S, Cheng L, et al. Vitamin K2 in Managing Nocturnal Leg Cramps: A Randomized Clinical Trial. JAMA Intern Med. 2024;184(12):1443-7. PubMed PMID: 39466236.

Hobbs FDR, McManus RJ, Taylor CJ, Jones NR, Rahman JK, Wolstenholme J, et al. Low-dose spironolactone and cardiovascular outcomes in moderate stage chronic kidney disease: a randomized controlled trial. Nat Med. 2024;30(12):3634-45. PubMed PMID: 39349629.

Diabetes Canada Clinical Practice Guidelines Expert Working G, Shah BR, Bajaj HS, Butalia S, Dasgupta K, Eurich DT, et al. Pharmacologic Glycemic Management of Type 2 Diabetes in Adults-2024 Update. Can J Diabetes. 2024;48(7):415-24. PubMed PMID: 39550176.

Thompson A, Fleischmann KE, Smilowitz NR, de Las Fuentes L, Mukherjee D, Aggarwal NR, et al. 2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2024;150(19):e351-e442. PubMed PMID: 39316661.

Yakovenko I, Mukaneza Y, Germe K, Belliveau J, Fraleigh R, Bach P, et al. Management of opioid use disorder: 2024 update to the national clinical practice guideline. CMAJ. 2024;196(38):E1280-E90. PubMed PMID: 39532476.

Singh S, Loftus EV, Jr., Limketkai BN, Haydek JP, Agrawal M, Scott FI, et al. AGA Living Clinical Practice Guideline on Pharmacological Management of Moderate-to-Severe Ulcerative Colitis. Gastroenterology. 2024;167(7):1307-43. PubMed PMID: 39572132.

Bushnell C, Kernan WN, Sharrief AZ, Chaturvedi S, Cole JW, Cornwell WK, 3rd, et al. 2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association. Stroke. 2024;55(12):e344-e424. PubMed PMID: 39429201.

Sico JJ, Antonovich NM, Ballard-Hernandez J, Buelt AC, Grinberg AS, Macedo FJ, et al. 2023 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline for the Management of Headache. Ann Intern Med. 2024;177(12):1675-94. PubMed PMID: 39467289.

https://cisssofil.ca/la-loi-de-vanessa/#:~:text=En%202000%2C%20une%20jeune%20fille,produits%20th%C3%A9rapeutiques%20par%20Sant%C3%A9%20Canada.

Dans cette 67e baladodiffusion, les Drs Luc Lanthier et Alexandre Mutchmore discutent d’apnée du sommeil et de tirzépatide, en plus de réviser la littérature médicale d’octobre 2024.

Quiz clinique (3 min 30), présentation principale (4 min 04), critique (25 min 00), retour sur le cas clinique (36 min 51), autres articles (38 min 45), réponse au quiz clinique (43 min 42)

Malhotra A, Grunstein RR, Fietze I, Weaver TE, Redline S, Azarbarzin A, et al. Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity. N Engl J Med. 2024;391(13):1193-205. PubMed PMID: 38912654.

Patel SR. Entering a New Era in Sleep-Apnea Treatment. N Engl J Med. 2024;391(13):1248-49. PubMed PMID: 38912659.

Veasey SC, Rosen IM. Obstructive sleep apnea in adults. N Engl J Med 2019; 380(15):1442-9. PubMed PMID: 30970189.

Benjafield AV, Ayas NT, Eastwood PR, et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med 2019;7(8):687-98. PubMed PMID: 31300334.

Bekker LG, Das M, Abdool Karim Q, Ahmed K, Batting J, Brumskine W, et al. Twice-Yearly Lenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women. N Engl J Med. 2024;391(13):1179-92. PubMed PMID: 39046157.

Silvain J, Cayla G, Ferrari E, Range G, Puymirat E, Delarche N, et al. Beta-Blocker Interruption or Continuation after Myocardial Infarction. N Engl J Med. 2024;391(14):1277-86. PubMed PMID: 39213187.

Bliddal H, Bays H, Czernichow S, Udden Hemmingsson J, Hjelmesaeth J, Hoffmann Morville T, et al. Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis. N Engl J Med. 2024;391(17):1573-83. PubMed PMID: 39476339.

McEvoy JW, McCarthy CP, Bruno RM, Brouwers S, Canavan MD, Ceconi C, et al. 2024 ESC Guidelines for the management of elevated blood pressure and hypertension. Eur Heart J. 2024;45(38):3912-4018. PubMed PMID: 39210715.

Del Galdo F, Lescoat A, Conaghan PG, Bertoldo E, Colic J, Santiago T, et al. EULAR recommendations for the treatment of systemic sclerosis: 2023 update. Ann Rheum Dis. 2024. Epub 2024/10/12. doi: 10.1136/ard-2024-226430. PubMed PMID: 39393843.

Kothari S, Afshar Y, Friedman LS, Ahn J. AGA Clinical Practice Update on Pregnancy-Related Gastrointestinal and Liver Disease: Expert Review. Gastroenterology. 2024;167(5):1033-45. PubMed PMID: 39140906.

Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL, Hirschmann JV, Kaplan SL, Montoya JG, Wade JC; Infectious Diseases Society of America. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014;59(2):e10-52. PubMed PMID: 24973422.

Dans cette 66e baladodiffusion, les Drs Alexandre Mutchmore et Luc Lanthier discutent de d’insuffisance cardiaque à fraction d’éjection préservée ou légèrement réduite et finérénone, en plus de réviser la littérature médicale de septembre 2024.

Quiz clinique (2 min 58), présentation principale (3 min 40), critique (32 min 55), retour sur le cas clinique (44 min 50), autres articles (46 min 57), réponse au quiz clinique (51 min 50)

Solomon SD, McMurray JJV, Vaduganathan M, Claggett B, Jhund PS, Desai AS, et al. Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2024;391(16):1475-85. PubMed PMID: 39225278.

Yusuf S, Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJ, Michelson EL, Olofsson B, Ostergren J; CHARM Investigators and Committees. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet. 2003;362(9386):777-81. PubMed PMID: 13678871.

Massie BM, Carson PE, McMurray JJ, Komajda M, McKelvie R, Zile MR, Anderson S, Donovan M, Iverson E, Staiger C, Ptaszynska A; I-PRESERVE Investigators. Irbesartan in patients with heart failure and preserved ejection fraction. N Engl J Med. 2008;359(23):2456-67. PubMed PMID: 19001508.

Pitt B, Pfeffer MA, Assmann SF, Boineau R, Anand IS, Claggett B, et al; TOPCAT Investigators. Spironolactone for heart failure with preserved ejection fraction. N Engl J Med. 2014;370(15):1383-92. PubMed PMID: 24716680.

Pfeffer MA, Claggett B, Assmann SF, Boineau R, Anand IS, Clausell N, et al. Regional variation in patients and outcomes in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) trial. Circulation. 2015;131(1):34-42. PubMed PMID: 25406305.

Pfeffer MA, Claggett B. Behind the Scenes of TOPCAT – Bending to Inform. NEJM Evid. 2022 Jan;1(1):EVIDctcs2100007. PubMed PMID: 38319229.

Solomon SD, McMurray JJV, Anand IS, Ge J, Lam CSP, Maggioni AP, et al. Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction. N Engl J Med. 2019;381(17):1609‑20. PubMed PMID: 31475794.

Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Böhm M, et al; EMPEROR-Preserved Trial Investigators. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021;385(16):1451-1461PubMed PMID: 34449189.

Solomon SD, McMurray JJV, Claggett B, de Boer RA, DeMets D, Hernandez AF, et al; DELIVER Trial Committees and Investigators. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2022;387(12):1089-1098. PubMed PMID: 36027570.

Bakris GL, Agarwal R, Anker SD, Pitt B, Ruilope LM, Rossing P, et al. Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes. N Engl J Med. 2020;383(23):2219-29. PubMed PMID: 33264825.

Pitt B, Filippatos G, Agarwal R, Anker SD, Bakris GL, Rossing P, Joseph A, Kolkhof P, Nowack C, Schloemer P, Ruilope LM; FIGARO-DKD Investigators. Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes. N Engl J Med. 2021 Dec 9;385(24):2252-2263. PubMed PMID: 34449181.

Vaduganathan M, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, et al. Time to Significant Benefit of Finerenone in Patients With Heart Failure. J Am Coll Cardiol. 2024. PubMed PMID: 39352338.

Vaduganathan M, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, et al. Estimated Long-Term Benefits of Finerenone in Heart Failure: A Prespecified Secondary Analysis of the FINEARTS-HF Randomized Clinical Trial. JAMA Cardiol. 2024. PubMed PMID: 39332395.

Ekstrom M, Andersson A, Papadopoulos S, Kipper T, Pedersen B, Kricka O, et al. Long-Term Oxygen Therapy for 24 or 15 Hours per Day in Severe Hypoxemia. N Engl J Med. 2024;391(11):977-88. PubMed PMID: 39254466.

Legrand M, Falcone J, Cholley B, Charbonneau H, Delaporte A, Lemoine A, et al. Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery: The Stop-or-Not Randomized Clinical Trial. JAMA. 2024;332(12):970-8. PubMed PMID: 39212270.

Ramacciotti E, Volpiani GG, Britto KF, Agati LB, Ribeiro CM, Aguiar VCR, et al. Rivaroxaban for Patients with Intermittent Claudication. NEJM Evid. 2024;3(9):EVIDoa2400021. PubMed PMID: 39185955.

Crean AM, Adler A, Arbour L, Chan J, Christian S, Cooper RM, et al. Canadian Cardiovascular Society Clinical Practice Update on Contemporary Management of the Patient With Hypertrophic Cardiomyopathy. Can J Cardiol. 2024;40(9):1503-23. PubMed PMID: 38880398.

Mazzolai L, Teixido-Tura G, Lanzi S, Boc V, Bossone E, Brodmann M, et al. 2024 ESC Guidelines for the management of peripheral arterial and aortic diseases. Eur Heart J. 2024;45(36):3538-700. PubMed PMID: 39210722.

Vrints C, Andreotti F, Koskinas KC, Rossello X, Adamo M, Ainslie J, et al. 2024 ESC Guidelines for the management of chronic coronary syndromes. Eur Heart J. 2024;45(36):3415-537. PubMed PMID: 39210710.

Van Gelder IC, Rienstra M, Bunting KV, Casado-Arroyo R, Caso V, Crijns H, et al. 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2024;45(36):3314-414. PubMed PMID: 39210723.

Kohler TS, Kloner RA, Rosen RC, Burnett AL, Blaha MJ, Ganz P, et al. The Princeton IV Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease. Mayo Clin Proc. 2024;99(9):1500-17. PubMed PMID: 39115509.

Chey WD, Howden CW, Moss SF, Morgan DR, Greer KB, Grover S, et al. ACG Clinical Guideline: Treatment of Helicobacter pylori Infection. Am J Gastroenterol. 2024;119(9):1730-53. 

Moody WE, Turvey-Haigh L, Knight D, Coats CJ, Cooper RM, Schofield R, et al. British Society of Echocardiography guideline for the transthoracic echocardiographic assessment of cardiac amyloidosis. Echo Res Pract. 2023;10(1):13. PubMed PMID: 37653443.

Fine NM, Davis MK, Anderson K, Delgado DH, Giraldeau G, Kitchlu A, et al. Canadian Cardiovascular Society/Canadian Heart Failure Society Joint Position Statement on the Evaluation and Management of Patients With Cardiac Amyloidosis. Can J Cardiol. 2020;36(3):322-334. PubMed PMID: 32145862.

Dans cette 65e baladodiffusion, les Drs Luc Lanthier et Michaël Mayette discutent de prophylaxie d’ulcère de stress chez les sujets sous ventilation mécanique, en plus de réviser la littérature médicale de juillet et août 2024.

Quiz clinique (3 min 00), présentation principale (3 min 25), critique (20 min 44), autres articles (27 min 10), réponse au quiz clinique (33 min 11)

Cook D, Deane A, Lauzier F, Zytaruk N, Guyatt G, Saunders L, et al; REVISE Investigators. Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation. N Engl J Med. 2024;391(1):9-20. PubMed PMID : 38875111.

Gao Y, Jiang L, Pan Y, Chen W, Jing J, Wang C, et al; INSPIRES Investigators. Immediate- or Delayed-Intensive Statin in Acute Cerebral Ischemia: The INSPIRES Randomized Clinical Trial. JAMA Neurol. 2024;81(7):741-751. PubMed PMID: 38805216.

Marcus MD, Link MS. Omega-3 Fatty Acids and Arrhythmias. Circulation. 2024;150(6):488-503. PubMed PMID: 39102482.

Valgimigli M, Hong SJ, Gragnano F, Chalkou K, Franzone A, da Costa BR, et al. De-escalation to ticagrelor monotherapy versus 12 months of dual antiplatelet therapy in patients with and without acute coronary syndromes: a systematic review and individual patient-level meta-analysis of randomised trials. Lancet. 2024;404(10456):937-48. PubMed PMID: 39226909.

Brown SM. Uncertain Answers – Proton-Pump Inhibition in the ICU. N Engl J Med. 2024;391(1):78-9. PubMed PMID: 38875100.

Wang Y, Parpia S, Ge L, Heels-Ansdell D, Lai H, Esfahani MA, et al. Proton-Pump Inhibitors to Prevent Gastrointestinal Bleeding – An Updated Meta-Analysis. NEJM Evid. 2024;3(7):EVIDoa2400134. PubMed PMID: 38874580.

MacLaren R, Dionne JC, Granholm A, Alhazzani W, Szumita PM, Olsen K, et al. Society of Critical Care Medicine and American Society of Health-System Pharmacists Guideline for the Prevention of Stress-Related Gastrointestinal Bleeding in Critically Ill Adults. Crit Care Med. 2024;52(8):e421-e30. PubMed PMID: 39007578.

Krag M, Marker S, Perner A, Wetterslev J, Wise MP, Schefold JC, et al. Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU. N Engl J Med. 2018;379(23):2199-208. PubMed PMID: 30354950.

Australian PIft, New Zealand Intensive Care Society Clinical Trials Group AHSCCSCN, the Irish Critical Care Trials G, Young PJ, Bagshaw SM, Forbes AB, et al. Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial. JAMA. 2020;323(7):616-26. PubMed PMID: 31950977.

Liu J, Li Y, Ge J, Yan X, Zhang H, Zheng X, et al. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial. Lancet. 2024;404(10449):245-55. PubMed PMID: 38945140.

Lu S, Kato T, Dong X, Ahn MJ, Quang LV, Soparattanapaisarn N, et al. Osimertinib after Chemoradiotherapy in Stage III EGFR-Mutated NSCLC. N Engl J Med. 2024;391(7):585-97. PubMed PMID: 38828946.

Landoni G, Monaco F, Ti LK, Baiardo Redaelli M, Bradic N, Comis M, et al. A Randomized Trial of Intravenous Amino Acids for Kidney Protection. N Engl J Med. 2024;391(8):687-98. PubMed PMID: 38865168.

Miyauchi K, Iwata H, Nishizaki Y, Inoue T, Hirayama A, Kimura K, et al. Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy-Statin and Eicosapentaenoic Acid (RESPECT-EPA). Circulation. 2024;150(6):425-34. PubMed PMID: 38873793.

EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). J Hepatol. 2024;81(3):492-542. PubMed PMID: 38851997.

Callum J, Skubas NJ, Bathla A, Keshavarz H, Clark EG, Rochwerg B, et al. Use of Intravenous Albumin: A Guideline From the International Collaboration for Transfusion Medicine Guidelines. Chest. 2024;166(2):321-38. PubMed PMID: 38447639.

Sharma R, Kouranos V, Cooper LT, Metra M, Ristic A, Heidecker B, et al. Management of cardiac sarcoidosis. Eur Heart J. 2024;45(30):2697-726. PubMed PMID: 38923509.

Umpierrez GE, Davis GM, ElSayed NA, Fadini GP, Galindo RJ, Hirsch IB, et al. Hyperglycemic Crises in Adults With Diabetes: A Consensus Report. Diabetes Care. 2024;47(8):1257-75. PubMed PMID: 39052901.

Vinter N, Cordsen P, Johnsen SP, Staerk L, Benjamin EJ, Frost L, Trinquart L. Temporal trends in lifetime risks of atrial fibrillation and its complications between 2000 and 2022: Danish, nationwide, population based cohort study. BMJ. 2024;385:e077209. PubMed PMID: 38631726.

Dans cette 64e baladodiffusion, le Dr Luc Lanthier discute de l’utilisation du sémaglutide comme thérapie néphroprotectrice dans l’insuffisance rénale chronique chez les personnes avec diabète type 2, en plus de réviser la littérature médicale de juin 2024.

Quiz clinique (1 min 55), présentation principale (2 min 40), critique (25 min 22), retour sur le cas clinique (35 min 04), autres articles (37 min 10), réponse au quiz clinique (40 min 17)

Perkovic V, Tuttle KR, Rossing P, Mahaffey KW, Mann JFE, Bakris G, et al. Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes. N Engl J Med. 2024;391(2):109-121. PubMed PMID: 38785209.

Herrington WG, Haynes R. Diabetic Kidney Disease – Semaglutide Flows into the Mainstream. N Engl J Med. 2024;391(2):178-179. PubMed PMID: 38986062.

Mann JFE, Rossing P, Bakris G, Belmar N, Bosch-Traberg H, Busch R, et al. Effects of semaglutide with and without concomitant SGLT2 inhibitor use in participants with type 2 diabetes and chronic kidney disease in the FLOW trial. Nat Med. 2024 Jun 24. doi: 10.1038/s41591-024-03133-0. PubMed PMID: 38914124.

https://kidneyfailurerisk.com

https://www.ontariorenalnetwork.ca/en/kidney-care-resources/clinical-tools/primary-care-tools/kidneywise/toolkit

Aaron SD, Vandemheen KL, Whitmore GA, Bergeron C, Boulet LP, Cote A, et al. Early Diagnosis and Treatment of COPD and Asthma – A Randomized, Controlled Trial. N Engl J Med. 2024;390(22):2061-73. PubMed PMID: 38767248.

Li S, Gu HQ, Li H, Wang X, Jin A, Guo S, et al. Reteplase versus Alteplase for Acute Ischemic Stroke. N Engl J Med. 2024;390(24):2264-73. PubMed PMID: 38884332.

Gibbs KW, Semler MW, Driver BE, Seitz KP, Stempek SB, Taylor C, et al. Noninvasive Ventilation for Preoxygenation during Emergency Intubation. N Engl J Med. 2024;390(23):2165-77. PubMed PMID: 38869091.

Bhatt SP, Rabe KF, Hanania NA, Vogelmeier CF, Bafadhel M, Christenson SA, et al. Dupilumab for COPD with Blood Eosinophil Evidence of Type 2 Inflammation. N Engl J Med. 2024;390(24):2274-83. PubMed PMID: 38767614.

McCormick N, Yokose C, Lu N, Wexler DJ, Avina-Zubieta JA, De Vera MA, et al. Sodium-Glucose Cotransporter-2 Inhibitors vs Sulfonylureas for Gout Prevention Among Patients With Type 2 Diabetes Receiving Metformin. JAMA Intern Med. 2024;184(6):650-60. PubMed PMID: 38619822.

Pacheco C, Coutinho T, Bastiany A, Beanlands R, Boczar KE, Gulati M, et al. Canadian Cardiovascular Society/Canadian Women’s Heart Health Alliance Clinical Practice Update on Myocardial Infarction With No Obstructive Coronary Artery Disease (MINOCA). Can J Cardiol. 2024;40(6):953-68. PubMed PMID: 38852985.

Ommen SR, Ho CY, Asif IM, Balaji S, Burke MA, Day SM, et al. 2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2024;149(23):e1239-e311. PubMed PMID: 38718139.

Gornik HL, Aronow HD, Goodney PP, Arya S, Brewster LP, Byrd L, et al. 2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2024;149(24):e1313-e410. PubMed PMID: 38743805.

Merz LE, Story CM, Osei MA, Jolley K, Ren S, Park HS, Yefidoff Freedman R, Neuberg D, Smeland-Wagman R, Kaufman RM, Achebe MO. Absolute neutrophil count by Duffy status among healthy Black and African American adults. Blood Adv. 2023;7(3):317-320. PubMed PMID: 35994632.

https://www.ncbi.nlm.nih.gov/books/NBK2271/

Dans cette 63e baladodiffusion, les Dr Luc Lanthier et Étienne Couture discutent de l’utilisation de la thérapie antiplaquettaire post-syndrome coronarien aigu, en plus de réviser la littérature médicale de mai 2024.

Quiz clinique (3 min 25), présentation principale (3 min 57), critique (27 min 00), autres articles (35 min 41), réponse au quiz clinique (38 min 12)

Ge Z, Kan J, Gao X, Raza A, Zhang JJ, Mohydin BS, et al; ULTIMATE-DAPT investigators. Ticagrelor alone versus ticagrelor plus aspirin from month 1 to month 12 after percutaneous coronary intervention in patients with acute coronary syndromes (ULTIMATE-DAPT): a randomised, placebo-controlled, double-blind clinical trial. Lancet. 2024;403(10439):1866-1878. PubMed PMID: 38599220.

Li X, Ge Z, Kan J, Anjum M, Xie P, Chen X, et al. Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention in acute coronary syndromes (IVUS-ACS): a two-stage, multicentre, randomised trial. Lancet. 2024;403(10439):1855-65. PubMed PMID: 38604212.

GBD 2021 Causes of Death Collaborators. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024;403(10440):2100-32. PubMed PMID: 38582094.

Urban P, Mehran R, Colleran R, Angiolillo DJ, Byrne RA, Capodanno D, et al. Defining High Bleeding Risk in Patients Undergoing Percutaneous Coronary Intervention. Circulation. 2019;140(3):240-61. PubMed PMID: 31116032.

Bainey KR, Marquis-Gravel G, Belley-Cote E, Turgeon RD, Ackman ML, et al. Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology 2023 Focused Update of the Guidelines for the Use of Antiplatelet Therapy. Can J Cardiol. 2024;40(2):160-81. PubMed PMID: 38104631.

Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J. 2023;44(38):3720-826. PubMed PMID: 37622654.

Lawton JS, Tamis-Holland JE, Bangalore S, Bates ER, Beckie TM, Bischoff JM, et al. 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145(3):e18-e114. PubMed PMID: 34882435.

Yusuf S, Zhao F, Mehta SR, et al; Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345(7):494-502. PubMed PMID: 11519503.

Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C, et al; PLATO Investigators; Freij A, Thorsén M. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361(11):1045-57. PubMed PMID: 19717846.

Mehran R, Baber U, Sharma SK, Cohen DJ, Angiolillo DJ, Briguori C, et al. Ticagrelor with or without Aspirin in High-Risk Patients after PCI. N Engl J Med. 2019;381(21):2032-42. PubMed PMID: 31556978.

Kim BK, Hong SJ, Cho YH, Yun KH, Kim YH, Suh Y, et al. Effect of Ticagrelor Monotherapy vs Ticagrelor With Aspirin on Major Bleeding and Cardiovascular Events in Patients With Acute Coronary Syndrome: The TICO Randomized Clinical Trial. JAMA. 2020;323(23):2407-16. PubMed PMID: 32543684.

Kim CJ, Park MW, Kim MC, Choo EH, Hwang BH, Lee KY, et al. Unguided de-escalation from ticagrelor to clopidogrel in stabilised patients with acute myocardial infarction undergoing percutaneous coronary intervention (TALOS-AMI): an investigator-initiated, open-label, multicentre, non-inferiority, randomised trial. Lancet. 2021;398(10308):1305-16. PubMed PMID: 34627490.

Hong SJ, Lee SJ, Suh Y, Yun KH, Kang TS, Shin S, et al. Stopping Aspirin Within 1 Month After Stenting for Ticagrelor Monotherapy in Acute Coronary Syndrome: The T-PASS Randomized Noninferiority Trial. Circulation. 2024;149(8):562-73. PubMed PMID: 37878786.

Natsuaki M, Watanabe H, Morimoto T, Yamamoto K, Obayashi Y, Nishikawa R, et al. An Aspirin-Free Versus Dual Antiplatelet Strategy for Coronary Stenting: STOPDAPT-3 Randomized Trial. Circulation. 2024;149(8):585-600. PubMed PMID: 37994553.

Steiner-Gager GM, Siller-Matula JM. Abbreviated dual antiplatelet therapy after acute coronary syndrome. Lancet. 2024;403(10439):1823-5. PubMed PMID: 38599219.

Connolly SJ, Sharma M, Cohen AT, Demchuk AM, Czlonkowska A, Lindgren AG, et al. Andexanet for Factor Xa Inhibitor-Associated Acute Intracerebral Hemorrhage. N Engl J Med. 2024;390(19):1745-55. PubMed PMID: 38749032.

Blankenberg S, Seiffert M, Vonthein R, Baumgartner H, Bleiziffer S, Borger MA et al; DEDICATE-DZHK6 Trial Investigators. Transcatheter or Surgical Treatment of Aortic-Valve Stenosis. N Engl J Med. 2024;390(17):1572-1583. PubMed PMID: 38588025.

Costalat V, Jovin TG, Albucher JF, Cognard C, Henon H, Nouri N, et al. Trial of Thrombectomy for Stroke with a Large Infarct of Unrestricted Size. N Engl J Med. 2024;390(18):1677-89. PubMed PMID: 38718358.

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