In episode 558, Mike and James decide to start to tackle the ketamine for depression story. Mike talks about what the media says about ketamine and then he delves into what the guidelines say. Then as always, we discuss the best available evidence. Have a listen so that you can be in the know about […]

Episode 557: Fancy Creams for Scaly Skin: Topical calcineurin inhibitors for atopic dermatitis In episode 557, Mike and James invite Emelie Braschi back to the podcast to talk about how effective topical calcineurin inhibitors are for atopic dermatitis. We’ll give you all the numbers so have a listen and learn what they are. Show notes […]

In episode 556, Mike and James have Betsy Thomas back to podcast to talk about how effective are artificial tears for people with dry eyes. Both of us cry halfway through the podcast because of the craziness and inconsistency of the evidence. Have a listen and see what we found. Show notes Tools for Practice […]

In episode 555, James and Mike invite Jamie Falk back to the podcast to talk about the best available evidence for acetylsalicylic acid and its potential impact on reducing the risk of complications in women at risk of preeclampsia. The evidence is pretty clear and we are able to give decent estimates of the benefits […]

In episode 554, James and Mike go over a topic we have never covered in 553 previous podcasts. We invited Samantha Moe back to the podcast to talk about how effective are pelvic floor exercises or pessaries for stress urinary incontinence. We find that the magnitude of the benefits from pelvic floor exercises is fairly […]

In episode 553, James and Mike get Jen Potter back to talk about the last option we have for heavy menstrual bleeding – tranexamic acid. We talk about how it compares to placebo, NSAIDs, progestins and levonorgestrel intrauterine devices and go over all the numbers for benefits and harms. And then as always, we put […]

In episode 552, James and Mike go over a couple of new trials. We talk about a blood pressure trial that examined taking the pills in the morning vs the evening and a heart failure trial that looked at getting patients on “high intensity” treatment. Find out the results here. Show notes Cardiovascular outcomes in […]

In episode 551, James and Mike invite Danielle Perry back to the podcast to talk about the best available evidence for the use of statins in people 65 and over. As you’ll hear, we have lots of evidence so all you need to know is what it says. Then, you can have an evidence-based discussion […]

In episode 549, James and Mike invite Blair MacDonald to the podcast for the first time and we talk about a topic that we haven’t really covered to-date. We discuss the evidence around what happens to the risk of pancreatitis when we use triglyceride-lowering medications (fibrates, statins, niacin, omega-3s) in patients with hypertriglyceridemia. Have a […]

In episode 548, James and Mike invite Betsy Thomas back to the podcast to talk about whether or not measuring lipoprotein(a) or apolipoprotein B improves cardiovascular risk prediction in a meaningful way over and above using standard risk factors. Many guidelines are now recommending we should do these measurements but is this an evidence-based recommendation? […]