In episode 555, James and Mike invite Jamie Falk back to the podcast to talk about the best available evidence for acetylsalicylic acid and its potential impact on reducing the risk of complications in women at risk of preeclampsia. The evidence is pretty clear and we are able to give decent estimates of the benefits […]

In episode 554, James and Mike go over a topic we have never covered in 553 previous podcasts. We invited Samantha Moe back to the podcast to talk about how effective are pelvic floor exercises or pessaries for stress urinary incontinence. We find that the magnitude of the benefits from pelvic floor exercises is fairly […]

In episode 553, James and Mike get Jen Potter back to talk about the last option we have for heavy menstrual bleeding – tranexamic acid. We talk about how it compares to placebo, NSAIDs, progestins and levonorgestrel intrauterine devices and go over all the numbers for benefits and harms. And then as always, we put […]

In episode 552, James and Mike go over a couple of new trials. We talk about a blood pressure trial that examined taking the pills in the morning vs the evening and a heart failure trial that looked at getting patients on “high intensity” treatment. Find out the results here. Show notes Cardiovascular outcomes in […]

In episode 551, James and Mike invite Danielle Perry back to the podcast to talk about the best available evidence for the use of statins in people 65 and over. As you’ll hear, we have lots of evidence so all you need to know is what it says. Then, you can have an evidence-based discussion […]

In episode 549, James and Mike invite Blair MacDonald to the podcast for the first time and we talk about a topic that we haven’t really covered to-date. We discuss the evidence around what happens to the risk of pancreatitis when we use triglyceride-lowering medications (fibrates, statins, niacin, omega-3s) in patients with hypertriglyceridemia. Have a […]

In episode 548, James and Mike invite Betsy Thomas back to the podcast to talk about whether or not measuring lipoprotein(a) or apolipoprotein B improves cardiovascular risk prediction in a meaningful way over and above using standard risk factors. Many guidelines are now recommending we should do these measurements but is this an evidence-based recommendation? […]

In episode 547, James and Mike invite Jessica and Scott back again to talk about whether or not COPD patients seen in primary care are like the people studied in the large COPD trials. We talk about how to focus care on the people who are most likely to benefit from therapy. There are lots […]

Episode 546: Who provides chronic disease management? In episode 546, James and Mike invite Jessica Kirkwood and Scott Garrison to talk about a new study they published looking at what proportion of common chronic medical conditions such as hypertension, diabetes and COPD are handled by family physicians, specialists, and nurse practitioners manage. We find that […]

In episode 545, James and Mike invite Samantha Moe back again to the podcast to talk about whether or not statins increase the risk of dementia or worsening of cognitive scores. I forgot the answer so you will have to listen to the podcast. Show Notes Tools for Practice Forget about it? Statins and the […]