In episode 520, James and Mike delve into the delicious area of ultra-processed food. We review all the best available evidence and try to put it into a digestible format. At the end we put a cherry on top to make it even more appetizing/interesting. Show Notes The Nutrition Proposition 1) Book website nutritionproposition.com 2)Amazon […]

In episode 519, Mike and James ask Jen Potter back to the podcast to talk about a common primary care question around oral contraceptives and breast feeding. We review the best available evidence which unfortunately we find out is not the highest quality. Nonetheless, we go over the numbers and then come up with useful, […]

In episode 518, Mike and James get Samantha to go through all the evidence we have for restricting lactose-containing foods in children with acute diarrhea. While we find out that looking at this evidence is at best tricky, it seems like reducing or diluting formula may provide a reasonable benefit. Listen to the podcast for […]

In episode 516, James and Mike invite Nicolas Dugré to the podcast yet again, and this time we talk about the evidence around the latest long-acting implantable reversible contraception. As always, we talk about the efficacy, the harm and all the rest of the issues around the use of these forms of contraception. Show Notes […]

In episode 515, James and Mike invite Allison Paige to the podcast for the first time. Alli takes us through all the evidence around a combination product (naltrexone/bupropion) for weight loss. We talk about all the numbers we have for benefit, harm and cost and we put this agent into the context of the other […]

In episode 514, James and Mike invite Betsy Thomas to the podcast for the first time. We look at a very common condition that many of us have at some point in our lives – allergic rhinosinusitis. We go over the best available evidence for the oral antihistamines and try to figure out which one […]

In episode 513, James and Mike invite Emelie Braschi to the podcast for the first time. We go over the best available evidence around the treatment of BPH and focus on the combination therapy of alpha-blockers and 5-alpha reductase and find as for many things there is an improvement in symptoms but also an increase […]

In episode 512, James and Mike finish going over the best available evidence around drinking alcohol. We look at what evidence says about the “red-wine” theory and the French Paradox. We also look at the evidence around alcohol and surrogate markers, and atrial fibrillation. We also examine the effect of social drinking on emotion and […]

In episode 511, James and Mike go on a binge and dissect the best available evidence around alcohol – more specifically 0-3 drinks a day. We look at what is a “drink” and then dive into one of the largest reviews of alcohol ever done. We explore what that evidence suggests about the harms and […]

In episode 510, Mike and James talk about a trial that looks at what happens when you discontinue antidepressants in primary care. We see there is about a 15% absolute difference in the chance of relapse – and we put all this into context because this is a PREMIUM podcast. We also discuss what happens […]