Welcome back to the trenches! In our final breakdown of the 2026 ACC/AHA lipid guidelines, we are unpacking the pharmacology toolbox. From statins and ezetimibe to PCSK9 inhibitors and the nuances of side effects like SAMS, I want to give you the practical, evidence-informed strategies we need for our patients. We are all just trying to navigate this together.

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CHAPTERS:
00:00 - Intro
00:01:00 - Statin Mechanism of Action
00:01:34 - Types of Statins and Intensities
00:03:04 - Hydrophobic vs Hydrophilic Statins
00:05:15 - Statins and Glycemic Control
00:06:14 - Pleiotropic Effects of Statins
00:07:12 - Statin Side Effects Overview
00:08:36 - Ezetimibe as First-Line Add-On
00:09:54 - Bempedoic Acid
00:11:18 - PCSK9 Inhibitors
00:13:16 - Inclisiran and siRNA Therapy
00:14:26 - Bile Acid Sequestrants
00:15:47 - The Rule of 6 and Combination Therapy
00:17:16 - Statin-Associated Muscle Symptoms
00:19:04 - CoQ10 Supplementation
00:20:07 - Special Populations: Older Adults and Pregnancy
00:21:20 - Liver Safety and Drug Interactions
00:23:15 - Statins, Dementia, and Brain Fog
00:24:23 - Statins and Diabetes Risk
00:25:21 - Managing High Triglycerides
00:27:06 - Conclusion and Summer Sabbatical

SELECTED REFERENCES:

https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423

*Disclaimer*
This podcast is for entertainment, education, and informational purposes only.
The topics discussed should not solely be used to diagnose, treat , or prevent any condition.
The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate.
Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.