Blood Podcast

In this week's episode we’ll discuss the prognostic value of the Chronic Lymphocytic Leukemia International Prognostic Index in the era of targeted therapies, learn how peak ADAMTS13 activity can be used to assess ADAMTS13 conformation and risk of relapse in immune-mediated thrombotic thrombocytopenic purpura, and discuss the findings from a phase 2 trial of haploidentical bone marrow transplant in sickle cell disease.

Featured Articles

• Reassessing the Chronic Lymphocytic Leukemia International Prognostic Index in the era of targeted therapies 
• Peak ADAMTS13 activity to assess ADAMTS13 conformation and risk of relapse in immune-mediated Thrombotic Thrombocytopenic Purpura 
• An international learning collaborative phase 2 trial for haploidentical bone marrow transplant in sickle cell disease 

In this week's episode we'll discuss assessing risk profile in Wiskott-Aldrich Syndrome, or WAS. Then, we'll learn about how the loss of DNMT3A confers resistance to interferon-alpha in hematopoietic stem cells carrying the JAK2-V617F mutation. Finally, we'll explore unrelated donor selection for AML patients undergoing hematopoietic stem cell transplantation with post-transplant cyclophosphamide.

Featured Articles: 

• Wiskott-Aldrich Syndrome: A retrospective study on 577 patients defines the genotype as a predictive biomarker for disease severity and survival
• Loss of Dnmt3a increased self-renewal and resistance to pegylated interferon-alpha in JAK2-V617F-positive myeloproliferative neoplasms 
• Younger unrelated donors may be preferable over HLA match in the PTCy era: A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

In this week's episode we’ll discuss the safety and efficacy of nilotinib with or without cytarabine in Philadelphia-positive acute lymphoblastic leukemia; learn more about thrombosis risk in double heterozygous carriers of Factor V Leiden and prothrombin G20210A and discuss the utility of circulating cell-free tumor DNA in prognostic prediction in patients with relapsed/refractory multiple myeloma.

Featured Articles:

• Nilotinib with or without cytarabine for Philadelphia positive acute lymphoblastic leukemia 
• Thrombosis risk in double heterozygous carriers of Factor V Leiden and Prothrombin G20210A in FinnGen and the UK Biobank 
• ctDNA improves prognostic prediction in relapsed/refractory multiple myeloma receiving ixazomib, lenalidomide, and dexamethasone 

In this week's episode we'll learn about fitusiran prophylaxis in patients with hemophilia A or B, with or without inhibitors. Next we'll hear about new findings that heterozygous germline variants in the NBN gene that are linked to increased risk of B-cell acute lymphoblastic leukemia in children. Finally, we'll explore new insights on the histone demethylase PHF8, which has been identified as a master regulator of cell-intrinsic immune responses in acute myeloid leukemia. 

Featured Articles:

• Fitusiran prophylaxis in people with hemophilia A or B who switched from prior BPA/CFC prophylaxis: the ATLAS-PPX trial
• Germline genetic NBN variation and predisposition to B-cell acute lymphoblastic leukemia in children 
• Epigenetic control over the cell-intrinsic immune response antagonizes self-renewal in acute myeloid leukemia

In this week's episode we’ll discuss the effects of voxelotor on cerebral blood flow in pediatric sickle cell disease, learn more about venous and arterial thrombosis in patients with Vexas syndrome, and discuss differential sensitivity to tyrosine kinase inhibitors in ABL-class acute lymphoblastic leukemia. 

Featured Articles:

• The influence of voxelotor on cerebral blood flow and oxygen extraction in pediatric sickle cell disease 
• Venous and arterial thrombosis in patients with VEXAS syndrome 
• Tyrosine kinase inhibitor response of ABL-class acute lymphoblastic leukemia: The role of kinase type and SH3 domain 

In this week's podcast we'll discuss another step forward in stamping out high-risk myeloma. Then we'll hear about the plasmin-cleaved von Willebrand factor, or VWF, in microthrombosis. Finally we'll hear about new insights into the origins of sickle cell pain. 

Featured Articles:

• Daratumumab, carfilzomib, lenalidomide, and dexamethasone with tandem transplant for high-risk newly
  diagnosed myeloma
• Plasmin-cleaved von Willebrand factor as a biomarker for microvascular thrombosis
• Sickle cell disease iPSC-derived sensory neurons exhibit increased excitability and sensitization to patient
  plasma

In this week's episode we’ll discuss the utility of MRD in identifying patients with NPM1 AML who benefit from allogeneic transplant in first remission, learn more about the contribution of circulating hematopoietic stem/progenitor cell subsets to human hematopoietic hemostasis, and discuss the role of Let-7 miRNAs in regulation of BCL11A transcription and hemoglobin switching. 

Featured Articles:

• Postinduction molecular MRD identifies patients with NPM1 AML who benefit from allogeneic transplant in first remission
• let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching 
• Circulating Hematopoietic Stem/Progenitor Cell subsets contribute to human hematopoietic homeostasis

In this week's epside we'll learn about ADAMTS recovery after caplacizumab therapy in patients with immune thrombotic thrombocytopenic purpura. Then, we'll hear about preclinical characterization of sonrotoclax, a potential second-generation BCL2 inhibitor. Finally we'll hear about new insights into the etiology of Castleman disease where researchers describe the unusual occurrence of idiopathic multicentric Castleman disease in identical twins. 

Featured Articles: 

• ADAMTS13 recovery in acute thrombotic thrombocytopenic purpura after caplacizumab therapy
• Sonrotoclax overcomes BCL2 G101V mutation–induced venetoclax resistance in preclinical models of
  hematologic malignancy
• Single-cell landscape of idiopathic multicentric Castleman disease in identical twins

In this week's episode, we’ll discuss the findings from a study assessing responses after treatment with tisagenlecleucel [LM1] in adults with relapsed/refractory follicular lymphoma, learn more about the association between high microRNA-145 plasma levels and decreased risk of future incident venous thromboembolism, and discuss how epigenetic and immunogenetic signatures can be used in the prediction of outcomes for high-count monoclonal B lymphocytosis.

Featured Articles: 

• Durable Response After Tisagenlecleucel in Adults With Relapsed/Refractory Follicular Lymphoma: ELARA Trial Update 
• Prediction of outcomes for high-count monoclonal B lymphocytosis using an epigenetic and immunogenetic signature 
• High microRNA-145 plasma levels are associated with decreased risk of future incident venous thromboembolism: The HUNT study 

In this week's episode, we'll discuss gut microbiota exploitation by CPX-351 in acute myeloid leukemia. Then we'll learn about optimizing anti-myeloma immunity. New research shows that regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation. Finally we'll discuss among pediatric patients with ITP or other autoimmune cytopenias, which ones will go on to develop systemic lupus? 

Featured Articles: 

• CPX-351 exploits the gut microbiota to promote mucosal barrier function, colonization resistance, and immune homeostasis
• Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation
• Antinuclear antibody–associated autoimmune cytopenia in childhood is a risk factor for systemic lupus erythematosus