Brandon Letsinger, a Seattle organizer and cofounding director of the Cascadia Department of Bioregion, discusses the history of bioregional activism in Cascadia and current challenges and strategies. Cascadia consists of three watersheds in the Pacific Northwest extending from British Columbia to northern California. For more than 40 years, Cascadia activists have been in the vanguard of a larger, now resurgent global movement. Its general goals are to reinvent markets, cultures and identities in ways that foster bioregional self-reliance and responsible stewardship of watersheds, energy, agriculture, wildlife, and other living systems.