This episode of “C. diff. Spores and More” is focused on “C. difficile Infections; The What, Where and How.” What is it, What can be done to prevent acquiring it, Where is it acquired, Where can clinicians and patients learn more about this infection, How is it being prevented at home and in the hospitals, How CDI’s are being treated, and How to learn more about the

prevention, treatments, and environmental safety products available With our special guests: Dr. Caterina Oneto,, MD and Dr. Paul Feuerstadt, MD, Both professors and physicians specializing in Gastroenterology with a wealth of knowledge and experience treating patients diagnosed with a CDI and through ongoing scientific/medical research.

In this episode Tex Kissoon, MD,a well-known doctor from Canada, will provide us with the insight into the global phenomenon of Sepsis. Sepsis affects more than 30 million lives per year yet it is almost unknown to the general public and is quite often misdiagnosed by medical professionals worldwide. The reasons of why that is with the why Sepsis is so deadly, and what you can do to increase Sepsis awareness-- will be discussed in the next 60 minutes. Dr. Kissoon is joined by Ray Schachter, a Sepsis survivor who has dedicated all of his available time to combating and raising awareness of Sepsis worldwide. Both are members of the Global Sepsis Alliance, which has established World Sepsis Day on September 13th every year to raise awareness for Sepsis worldwide.

According to the Centers for Disease Control and Prevention (CDC) report published in

February 2015, almost 500,000 C.diff. infections occurred in the U.S. in 2011, with 83,000 recurrences. Join our guests, C. diff. survivors, Heather Clark, Veronica Edmond, Renetta Dudzinski, and Lisa Hurka-Covington as they bravely share their story and unique journey through a C. diff. infection that forever changed their lives.

The Centers for Disease Control and Prevention (CDC) sounds the alarm on the danger of modern medicine returning to a time when simple infections were often fatal. As the latest Vital Signs Report shows, much progress has been made in our hospitals and healthcare facilities to protect patients from

healthcare-associated infections. But, more work needs to be done, because many of these infections are caused by antibiotic-resistant bacteria which are difficult, if not impossible to treat. The CDC believes clinicians are key to national progress in preventing infections. They have the power to change the direction of antibiotic resistance each and every time they care for their patients. It requires taking the appropriate steps every time. We are in a race to slow resistance, and we can’t afford to let the “superbugs” outpace us, especially in healthcare settings.

This episode introduces Seres Therapeutics, a leading microbiome therapeutics company, which recently published in the Journal of Infectious Diseases positive results from an open-label Phase 1b/2 study of SER-109 for the treatment of patients with recurrent

C. difficile infections (CDI). Seres Therapeutics is creating a new class of medicines to treat diseases resulting from functional deficiencies in the microbiome, a condition known as dysbiosis. New insights into the human microbiome are fundamentally reshaping how we understand and treat a wide range of diseases, creating new possibilities for patients not served by current therapeutic approaches. Ecobiotics are ecological compositions of beneficial organisms that are designed to reestablish a healthy microbiome. The discovery efforts at Seres Therapeutics currently span metabolic, inflammatory, and infectious diseases.

This interview will include forward-looking statements on Seres Therapeutics current expectations and projections about future events. These statements are based upon current beliefs, expectations and assumptions, and are subject to a number of important risks and uncertainties, including those set forth in Seres Therapeutics filings with the SEC, many of which are difficult to predict. Actual results may differ materially from such statements. The information included in this interview is provided only as of the date of this interview, and Seres Therapeutics undertakes no obligation to update any forward-looking statements stated in this interview on account of new information, future events, or otherwise, except as required by law. Seres Therapeutics has provided financial support to the C Diff Foundation.

Join us with our guest Glenn Taylor - Microbiologist at the Taymount Clinic just outside London in the UK. Glenn has spent five years researching the commensal colonization of bacteria in the human digestive system. The Taymount Clinic are known internationally as a specialist center for the production of tested, certified, high quality gut bacteria and effective, efficient implant techniques Researching intestinal bacteria since 2006, the Taymount Clinic is now a recognized world leader in applying Fecal / Faecal Microbiota Transplant or FMT treatment procedures to create a “normal” bacterial environment in patients with a broad range of conditions. The Taymount clinic provides FMT treatment to normalize gut bacteria in patients with a Clostridium difficile infection.

Sanofi Pasteur, one of the leading vaccine manufacturers in the world, is in the midst of its Phase III clinical trial called Cdiffense to study its investigational vaccine to prevent Clostridium difficile infection (CDI). The trial is now in more than 20 countries across 5 continents to evaluate the safety, immunogenicity and efficacy of an investigational vaccine for the prevention of primary, symptomatic CDI.

The investigational C. diff vaccine is designed to produce an immune response that targets the toxins generated by C. diff bacteria, which can cause inflammation of the gut. The investigative vaccine ultimately may help prevent a future infection from occurring. Volunteers for the study should be age 50 or older and planning an upcoming hospitalization or have had at least two hospital stays and have received systemic antibiotics in the past year. For more information on the Cdiffense trial, please visit www.Cdiffense.org

This episode introduces Seres Therapeutics, a leading microbiome therapeutics company, which recently published in the Journal of Infectious Diseases positive results from an open-label Phase 1b/2 study of SER-109 for the treatment of patients with recurrent

C. difficile infections (CDI). Seres Therapeutics is creating a new class of medicines to treat diseases resulting from functional deficiencies in the microbiome, a condition known as dysbiosis. New insights into the human microbiome are fundamentally reshaping how we understand and treat a wide range of diseases, creating new possibilities for patients not served by current therapeutic approaches. Ecobiotics are ecological compositions of beneficial organisms that are designed to reestablish a healthy microbiome. The discovery efforts at Seres Therapeutics currently span metabolic, inflammatory, and infectious diseases.brbr

This interview will include forward-looking statements on Seres Therapeutics current expectations and projections about future events. These statements are based upon current beliefs, expectations and assumptions, and are subject to a number of important risks and uncertainties, including those set forth in Seres Therapeutics filings with the SEC, many of which are difficult to predict. Actual results may differ materially from such statements. The information included in this interview is provided only as of the date of this interview, and Seres Therapeutics undertakes no obligation to update any forward-looking statements stated in this interview on account of new information, future events, or otherwise, except as required by law. Seres Therapeutics has provided financial support to the C Diff Foundation.

Join us as Dr. Hudson Garrett discusses effective ways being used to prevent acquiring a C. difficile infection (CDI) and Carbapenem-resistant Enterobacteriaceae (CRE), treatments available, and environmental safety - infection prevention in hospitals, long-term care, and at home.

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Dr. Garrett is a recognized international expert in infection prevention and control. Dr Garrett currently serves as the Chair of the Education Committee for the C Diff Foundation and is a graduate of the Johns Hopkins Fellows Program in Infection Control and Hospital Epidemiology. He was honored as a Who’s Who for Infection Control by Infection Control Today Magazine in 2013 in recognition of his contributions to the field.

This episode is focused on using antibiotics wisely and how YOU can help in the fight of antibiotic resistance.

Listen in as these two stellar Physicians discuss the topics of Clostridium difficile infections and Antibiotic usage. Important topics for citizens on a global level.