In this month's issue of CHEST, Dr. Peter J. Kahrilas, MD et al. provide a systematic review on the value of acid-suppressive therapy to those with chronic cough. In this month's podcast, Dr. Kahrilas, editorialist Michael F. Vaezi, MD, PhD, and CHEST Podcast Editor D. Kyle Hogarth, MD, FCCP, discuss the problems of selecting patients who would benefit, of conducting trials that would provide insight for clinicians into potential theapies, and of determining causality between gastroesphgeal reflux disease and chronic cough.