In this episode Preston and Margaret explore the endocannabinoid system, cannabis, and its impact on mental health. They break down the science behind CB1 and CB2 receptors, explain why marijuana affects people so differently, and discuss the complex relationship between THC, CBD, and dopamine. Along the way, they tackle myths about cannabis use, addiction, and medical marijuana, shedding light on what we actually know—and what remains a mystery due to historical barriers to research.

Takeaways:

The Endocannabinoid System is Vast and Mysterious: CB1 and CB2 receptors exist throughout the body, influencing pain, pleasure, nausea, and more—but the full scope of their role remains unclear.

Marijuana’s Effects Depend on the User: Some people experience relaxation and appetite stimulation, while others develop anxiety, paranoia, or even worsening nausea with chronic use.

The THC-to-CBD Ratio Matters: Over time, cannabis strains have been bred to increase THC potency, which may contribute to heightened psychiatric risks, including psychosis.

Cannabis Can Have Severe Side Effects: Long-term use can lead to cannabinoid hyperemesis syndrome (CHS)—a condition causing severe nausea and vomiting—and may increase the risk of cannabis-induced psychosis in predisposed individuals.

Medical Cannabis Outpaced the Research: While cannabis is now widely used for medical purposes, much of its effectiveness is anecdotal, and research on its long-term mental health impacts is still catching up.

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Watch on YouTube: @itspresro

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Produced by Dr Glaucomflecken & Human Content

Get in Touch: howtobepatientpod.com

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