Cardiac Consult: A Cleveland Clinic Podcast for Healthcare Professionals

Krishna Aragam, MD, Michael Hill, MD, and Christina Rigelsky, MS, CGC, discuss how cardiovascular genomics is transforming the evaluation and management of inherited conditions like heart disease, cardiomyopathies, arrhythmias and aortopathies. The conversation explores genetic testing, family screening, and emerging opportunities to personalize prevention and treatment based on genomic insights.

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

In this excerpt from Tall Rounds®,  Luke Laffin, MD, discusses the evolving role of renal denervation for uncontrolled hypertension, including guideline recommendations and the physiologic mechanisms underlying blood pressure reduction. Dr. Laffin reviews pivotal clinical trial data and examines the efficacy and safety evidence supporting the integration of renal denervation into contemporary hypertension management.

View other Tall Rounds programs. https://2207941.mediaspace.kaltura.com/category/Tall+Rounds/75663251

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

In this excerpt from Tall Rounds®, Cleveland Clinic experts discuss imaging modalities that aid the diagnosis of cardiac sarcoidosis. The conversation explores diagnostic challenges, risk stratification, interpretation pitfalls and the role of serial imaging in assessing treatment response and guiding clinical decision-making.

View other Tall Rounds programs. https://2207941.mediaspace.kaltura.com/category/Tall+Rounds/75663251

Meet the presenters:
Amanda Vest, MBBS https://providers.clevelandclinic.org/provider/amanda-vest/4268489
Christine Jellis, MD https://providers.clevelandclinic.org/provider/christine-jellis/4271993?
Bryan Abadie, MD https://providers.clevelandclinic.org/provider/bryan-abadie/4959422?

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

Eric Roselli, MD, and Patrick Vargo, MD, discuss how advances in open, hybrid and endovascular techniques are changing the treatment of aortic arch disease. They explore evolving approaches to aneurysms and dissections, innovations in brain protection and the role of specialized aortic centers in improving patient outcomes.

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

Milind Desai, MD, and Per Wierup, MD, discuss the evaluation and management of high-risk aortic valve endocarditis, including indications for urgent intervention and timing of surgery. They also review operative approaches to patients with heart failure, uncontrolled infection and embolic risk, highlighting the role of multidisciplinary expertise in complex endocarditis care

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

Luke Laffin, MD, speaks with Steven Nissen, MD, about findings from the ALPACA trial evaluating lepodisiran and its effects on oxidized phospholipids and lipoprotein(a). They discuss the potential mechanisms linking lipoprotein(a) to cardiovascular risk and how ongoing phase 3 research may shape future management of patients with elevated lipoprotein(a).

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

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In this excerpt from Tall Rounds®, Gianluca Torregrossa, MD, discusses minimally invasive and totally endoscopic coronary artery bypass grafting (TECAB), highlighting procedural advances that enable multi-vessel revascularization through less invasive approaches.

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

View the full Tall Rounds program. https://2207941.mediaspace.kaltura.com/category/Tall+Rounds/75663251

Steven Nissen, MD, and Luke Laffin, MD, discuss one-year follow-up data for CTX310, a CRISPR-Cas9 gene-editing therapy targeting ANGPTL3 to treat lipid disorders. They review the sustained reductions in LDL cholesterol and triglycerides, and the potential role of one-time gene-editing therapies in cardiovascular prevention and lipid management.

Read the article. https://consultqd.clevelandclinic.org/effects-of-crispr-cas9-gene-editing-for-dyslipidemia-endure-1-year

Steven Nissen, MD, and Ashish Sarraju, MD, discuss early clinical data on Kylo-11, a novel therapy that produced substantial reductions in lipoprotein(a) for up to one year after a single injection. Lowering lipoprotein(a), a genetically determined cardiovascular risk factor linked to atherosclerotic disease and aortic stenosis, remains an important focus for preventive cardiology. Learn about the new drug's mechanism and safety findings. 

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.

Marc Gillinov, MD, and Per Wierup, MD, discuss the evolution of robotic valve surgery, including advanced mitral valve repair techniques, patient selection and expanding applications for aortic valve and coronary procedures. They examine how enhanced visualization, instrument dexterity and a mature robotic program support excellent safety, durability and clinical outcomes.

Looking to refer a patient? Please reach out to our Physician Referral team Mon. - Fri., 8 a.m. - 5 p.m. (ET) at 855.751.2469.