Jess and Seth talk about the keys for the Cardinals to beat the Bills this weekend, go over important matchups and then give their best bets to make in the game this weekend.

Cardinals-Bills Week 1 preview, predictions and best bets

All about the Arizona Cardinals. It's the best hour of Cardinals talk on the Web! Hosted by Jess Root and Seth Cox, media analysts who are also lifelong Cardinals fans. Reactions, opinions and analysis given from their perspectives as fans and media insiders.

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Cardinals-Bills Week 1 preview, predictions and best bets

Cardinals-Bills Week 1 preview, predictions and best bets

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