In this CME episode, Vivian Hernandez-Trujillo, MD, FAAAAI, gives a primer on evaluating children who seem to be sick more than the average child. Spoiler alert: Before even thinking about testing, a detailed clinical history, comorbid conditions and environmental factors, and a wide ranging differential diagnosis must all be considered. Testing, especially which types of tests to consider, is covered in detail as well. Visit https://www.aaaai.org/professional-education-and-training/podcasts for CME information.