Wen Wee Ma, MBBS, Enterprise Vice Chair for Research and Director of the Novel Cancer Therapeutics Center, joins the Cancer Advances Podcast to discuss a phase 1 trial of KB707 presented at ASCO 2025. This innovative therapy delivers IL-2 and IL-12 directly to the lungs through inhalation, aiming to minimize side effects and improve outcomes for patients with lung tumors. Dr. Ma shares early trial results and what they could mean for the future of cancer treatment.

Kelley Kozma, DO, MS, Medical Director for Oncology at Cleveland Clinic Martin Health in Florida, to discuss how targeted therapies, next generation sequencing, and personalized medicine are transforming breast cancer care. Listen as Dr. Kozma shares how innovations like HER2-low targeting, liquid biopsy, and circulating tumor DNA are helping clinicians tailor treatments and improve outcomes.

Brian Burkey, MD, MEd, Interim Director of the Scully Walsh Cancer Center and Division Chair of Otolaryngology Head and Neck Surgery at Cleveland Clinic in Florida, joins the Cancer Advances Podcast to talk about management strategies for clinically node-negative salivary gland cancer. Listen as Dr. Burkey highlights findings from an outcomes study and share strategies to better identify high-risk patients who may benefit from more aggressive treatment.

George Stark, PhD, and Christine McDonald, PhD, from Cleveland Clinic’s Lerner Research Institute, join the Cancer Advances Podcast to discuss the development of PALA as a novel immunostimulatory agent in oncology. Listen as they highlight promising preclinical data across multiple tumor types, potential for combination therapies and plans for clinical translation, including topical use for skin cancer.

The Cancer Advances Podcast welcomes back Sudha Amarnath, MD, a Radiation Oncologist and Co-Director of the Gynecologic Cancer Program at Cleveland Clinic to discuss the potential of self-collected HPV tests to expand access to cervical cancer screening. Listen as Dr. Amarnath shares insights into how these tests work, their FDA approval, and their potential to reach underserved populations who face barriers to traditional screening methods.

Megan Kruse, MD, a Medical Oncologist and Director of the Clinical Breast Cancer Research Program at Cleveland Clinic joins the Cancer Advances Podcast to share breast cancer research highlights from the 2025 ASCO Conference. She discusses key findings from studies in metastatic hormone receptor-positive, triple-negative, and HER2-positive breast cancer, including potential practice-changing data on oral SERDs, antibody-drug conjugates, and ctDNA testing.

Rafael Arteta-Bulos, MD, a Genitourinary Medical Oncologist at Cleveland Clinic’s Maroone Cancer Center in Weston, Florida, joins the Cancer Advances Podcast to discuss the use of virtual reality in the care of patients with cancer. Dr. Arteta shares how this emerging technology is being studied as a supportive tool to reduce distress, anxiety, and improve overall well-being during chemotherapy.

Laura Bukavina, MD, MPH, a Urologic Oncologist and Translational Research Lead for genitourinary oncology at Cleveland Clinic joins the Cancer Advances Podcast to talk about strategies to improve the survivorship experience for women with bladder cancer, including treatment advances, quality-of-life considerations and encouraging open conversations to drive better survivorship programs.

Akriti Jain, MD, a Hematologist and Medical Oncologist specializing in leukemia and myeloid disorders at Cleveland Clinic, joins the Cancer Advances Podcast to discuss personalizing treatment approaches for myelofibrosis-associated anemia. Listen as Dr. Jain provides insights into the evolving therapeutic landscape, explaining how the field has expanded beyond single-agent therapy.

The Cancer Advances Podcast welcomes back Emre Gorgun, MD, Vice Chair of the Department of Colorectal Surgery and Co-Director of the Endoluminal Surgery Center at Cleveland Clinic, for his fifth appearance to discuss endoscopic submucosal dissection (ESD) in managing early-stage colorectal cancer. Listen as Dr. Gorgun outlines the technique, compares it to traditional surgical approaches, and shares insights from recent research demonstrating its safety, oncologic efficacy, and impact on quality of life.