Young patients requiring pelvic radiation face limited fertility preservation options. In this episode of Cancer Advances, Robert DeBernardo, MD, and Johanna Kelley, MD, both gynecologic oncologists at Cleveland Clinic, discuss uterine transposition—a novel surgical approach that protects both ovarian function and the uterus—using a real world rectal cancer case. Learn which patients may benefit, how the multidisciplinary model works and what this technique could mean for counseling, referrals and long term reproductive outcomes.

Shilpa Gupta, MD, Genitourinary Medical Oncologist, joins the Cancer Advances podcast to explore how perioperative immunotherapy and ctDNA are redefining management of muscle-invasive bladder cancer. She reviews emerging phase III data and explains how it can inform treatment selection, referral timing and adjuvant decision making in clinical practice.

Lilyana Angelov, MD, Neurosurgeon and Director of the Cleveland Clinic Gamma Knife Center, Samuel Chao, MD, Radiation Oncologist and Associate Director of the Gamma Knife Center; and Ajit Krishnaney, MD, Neurosurgeon in the Center for Spine Health, join the Cancer Advances podcast to share insights from 20 years of a multidisciplinary spine tumor board. Learn how multidisciplinary strategies and newer technologies are improving decision-making, local control and patient outcomes.

Amy Smith, MD, Pediatric Neuro-Oncologist, joins the Cancer Advances podcast to discuss recent progress in pediatric neuro-oncology. Listen as Dr. Smith explains the advances in tumor biology that are shaping treatment decisions and shares how recent FDA approvals for pediatric low-grade gliomas and diffuse midline gliomas are improving disease control and patient outcomes.

Brian Barnett, MD, Director of the Cleveland Clinic Psychiatric Treatment Resistance Program, joins the Cancer Advances podcast to discuss adjustment disorder in patients with cancer. Dr. Barnett shares how oncologists can better recognize this condition and provides insights on screening and treatment strategies. He also highlights emerging research on psychedelic-assisted therapy that may expand care options for these patients.

Thuy Nguyen, DAOM, LAc, Section Head of Acupuncture for the Wellness ad Preventive Medicine Department at Cleveland Clinic, joins the Cancer Advances podcast discuss how acupuncture is being integrated into cancer care. Listen as she explains the evidence behind using acupuncture for managing treatment-related symptoms, how acupuncture works biologically, key safety considerations and when oncologists should consider referral as part of an integrative oncology approach.

Director of the Inpatient Leukemia Unit, Anjali Advani, MD joins the Cancer Advances podcast to break down the latest acute myeloid leukemia clinical trials. From venetoclax-based regimens to emerging menin inhibitors and mutation-driven strategies, listen as Dr. Advani explains how rapid genomics, novel combinations and evolving transplant decisions are reshaping AML care and what still lies ahead for high-risk disease.

Could removing heat improve safety in endoscopic mucosal resection? Florida Division Chair of the Department of Gastroenterology, Hepatology and Nutrition, and the Florida Region Director for Endoscopy, Tolga Erim, DO, joins the Cancer Advances podcast to break down cold EMR how it compares to traditional EMR, including key differences in bleeding risk, recurrence rates, and clinical trade-offs.

Mina Lobbous, MD, MSPH, Neuro-Oncologist and Medical Director of the Adult Neurofibromatosis and Schwannomatosis Clinic at Cleveland Clinic, joins the Cancer Advances podcast to talk about the landscape of neurofibromatosis and schwannomatosis care. Listen as Dr. Lobbous emphasizes the importance of coordinated pediatric‑to‑adult care, highlighting the emergence of MEK inhibitors and transformational advances in imaging and genomics. 

The Cancer Advances Podcast welcomes back Nathan Mesko, MD, Vice Chair of Global Clinical Operations for the Department of Orthopaedic Surgery and Center Director for Musculoskeletal Oncology at Cleveland Clinic to talk about chemotherapy, limb salvage surgery and how 3D printed custom implants are reshaping outcomes in osteosarcoma. Dr. Mesko also shares a remarkable pediatric case whose complex reconstruction highlights the power of multidisciplinary care, surgical innovation and long term functional recovery.