Daphne Koller is the CEO and founder of insitro, a machine learning-enabled drug discovery company. Previously, she was a professor of computer science at Stanford University for 18 years, co-founder and co-CEO of Coursera, and the Chief Computing Officer of Calico, an Alphabet company in the healthcare space. She received the MacArthur Foundation Fellowship in 2004. In this conversation with Stanford adjunct lecturer Ravi Belani, Koller examines the key turning points in her diverse and innovative career, and speaks about how she searched for the opportunities that would have the greatest impact on the world.