“Code blue, unit 305. Code blue, unit 305.” After an 8-year-old boy with recurrent episodes of rhabdomyolysis is hospitalized for treatment of a rare inherited disease, his condition quickly deteriorates.

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A 35-year-old man thought he had outgrown the rare disorder which he was diagnosed with as a child. But as his movement becomes increasingly limited, he realizes that he never escaped it, and now there’s more than just his mobility at stake.

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Welcome back to DDx, a show about how doctors think. In Season 3, focused on rare disease, you’ll meet the doctors searching for the zebra among a herd of horses. Join host Dr. Raj Bhardwaj as he explores the challenges in distinguishing rare diseases from common ones, and how to recognize them when the stakes are life and death.

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A routine surgery leads to a puzzling reaction. Is more surgery required, or is it something else?

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A common skin condition affects much more than a patient’s skin, and misinformation only exacerbates the stigma.

This episode is brought to you by Novartis Pharmaceuticals Corporation. 

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A dermatologist is paged to examine a rare condition. But something doesn’t add up.

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While skin findings can sometimes help with a diagnosis, they can also distract from other undiagnosed symptoms.

This episode is brought to you by Novartis Pharmaceuticals Corporation.

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What do you do when faced with a set of symptoms that has two contradictory courses of treatment?

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Unconscious bias can run so deep that patients and doctors alike can miss a potentially fatal diagnosis.

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A patient presents with fever, swollen digits, and skin “the color of a red delicious apple.” She’s been scratching so hard that she’s bleeding through her shirt. What’s going on?

This episode is brought to you by Novartis Pharmaceuticals Corporation. 

Head to Figure1.com/ddx, where you can find full show notes, photos, and speaker bios.