1) Results of two-year B-vitamin treatment on cognitive performance and 2) Topic of the month: Living legend interviews: A career as a neurologist. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Jeff Burns interviews Ms. Nikita van der Zwaluw & Dr. Rosalie A. M. Dhonukshe-Rutten about their paper on the results of a two-year B-vitamin treatment for cognitive performance. Dr. James Addington is reading our e-Pearl of the week about Rasmussen encephalitis. In the next part of the podcast Dr. Stacey Clardy interviews Dr. Philip Low about his career as a neurologist. The participants had nothing to disclose except Drs. Burns, Addington and Low.Dr. Jeff Burns serves on the editorial board for Journal of Alzheimer's Disease; receives royalties for the publications of Early diagnosis and treatment of mild cognitive impairment and Dementia: An atlas of investigation and diagnosis; is a consultant for PRA International and receives research support from the NIH, Alzheimer's Drug Discovery Foundation, Elan, Janssen Pharmaceuticals Inc., Wyeth, Pfizer Inc, Novartis Pharmaceuticals Ltd, Danone, Avid Radiopharmaceuticals, Merck Serono and for clinical trials.Dr. Addington serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Low serves as Clinical Editor for Autonomic Neuroscience; is a consultant for WR Medical Electronics, Inc. and receives research support from the NIH and FDA.