Kirsty Young's castaway this week is the scientist, Professor Dame Nancy Rothwell, who is best known for her work in the field of neuroscience and stroke research. She is now President and Vice-Chancellor of Manchester University.

Could it be that her interest in how we keep the human body alive and functioning began when, aged eight, she contracted primary tuberculosis and was so ill she spent 18 months at home?

She says, "Like most academics my fate was sealed during my PhD, I fell in love with research and vowed I would do it until retirement. I was also sure that I would do my utmost to avoid any of those nasty administrative jobs."

Producer: Christine Pawlowsky.

Kirsty Young's castaway this week is the actor Ray Winstone.

Nil By Mouth, Sexy Beast, Vincent, The Sweeney - he's probably best known for totally authentic tough-guy, geezer-parts. But his work has more range and nuance, encompassing roles as varied as Henry VIII, Magwich in Great Expectations and the lead in Beowulf.

Beyond the screen the man himself almost seems to come from a bygone era, when a fellow worth his salt always wore a dapper three piece suit and was handy with his fists. In his youth as a boxer he won 80 of his 88 fights and it seemed for a while that a whiff of menace had followed him out of the ring and onto the streets.

However he says, "I'm not like the geezers I play: loads of things scare me in everyday life but you have to hide a bit and put on a front. I cry at movies, I cry at scripts, I cried when West Ham got back into the Premiership - I'm even frightened of spiders."

Producer: Cathy Drysdale.

Kirsty Young's castaway for Christmas week is The Archbishop of Canterbury, the Most Reverend Justin Welby.

Ordained as a priest in 1993, 19 years later he was appointed to lead the Anglican communion of over 77 million people spread across 167 countries. Hardly a front runner when the job vacancy came up he said that it would be "a joke" and "perfectly absurd" if he were appointed.

His faith has brought him high office but when he 'found God' at university, it gave him something a good deal more significant: a sense of much needed comfort after an often turbulent and uncertain childhood. Although his mother's side of the family provided stability, his father was an alcoholic and his childhood was punctuated by his parents' early divorce and significant money worries - one particular Christmas was spent hungrily staring out of the window as his father lay in bed all day.

He says, "When the church is working it is the most mind-bogglingly, amazingly, extraordinarily beautiful community on earth. It heals, it transforms, it loves, and it changes society."

Producer: Cathy Drysdale.

From Paul McCartney to Wham!

Comedian Sarah Millican shares her castaway choices with Kirsty Young.

Her every woman yet no-holds-barred style of comedy has brought her sell-out tours and several of her own highly successful TV series. Revelling in normality and drawing on the difficult, intimate and ofter extruciating moments of being human, she dares to say what most of us are thinking, only she's much funnier.

A Geordie, born in South Shields, her dad was an engineer down the mines and her mum was a hairdresser. They encouraged their daughter in her storytelling and performing even though her childhood shyness meant she'd recite her poetry from behind the living room curtains.

Later it was pain that first propelled her onto the stage when a broken early marriage provided the catalyst she needed to find the courage to confront the glaring judgement of the audience's gaze. Her rise was then rapid. Within four years she was awarded the Best Newcomer prize at the Edinburgh Fringe.

She says, "People come along and think, 'oh she's being too rude'. They don't realise I'm just like this at home. People think I'm prim and proper at home but I'm not - I'm just me transplanted onto the stage".

First broadcast on BBC Radio 4 December 2014.

Kirsty Young's castaway this week is the Chief Executive of the Guide Association, Julie Bentley - or, more accurately, Girlguiding.

The name change is surely a clue to the evolving nature of an organisation determined to be relevant and useful to girls in the 21st century. Indeed being relevant and useful is how Julie Bentley has spent her entire working life. From her early efforts at an HIV charity to running the Family Planning Association she says her passion lies with helping young people develop confidence and direction.

Never a Brownie or Girl Guide herself, she was brought up in what she describes as "a happy working class family in Essex" and it took her a little while to find her own self assurance and sense of purpose. A painfully shy child, who was bullied at primary school, she later went on to become Head Girl, but left school with very few qualifications. In her 30s she used a bequest from her mother to fund her Master's degree.

She says of the Girl Guides, "It is not about itchy brown uniforms and sewing and baking. It is a modern, contemporary, vibrant organisation."

Producer: Christine Pawlowsky.

Kirsty Young's castaway this week is the actor, Damian Lewis.

As part of the wave of British talent that's crashed onto America's shores in recent years his impact has made a deep impression on the creative landscape. His role as Sergeant Brodie in Homeland saw him win both an Emmy and Golden Globe and along with Band of Brothers, The Forsyte Saga and a long list of other credits, he now ranks as one of our most well recognised and highly regarded performers.

Things didn't always look so peachy: aged 11, and in the school production of Princess Ida, he forgot the entire third act and stood mute in front of a packed auditorium. Tellingly, rather than scuttling into the wings with shame he soldiered on and by 16 he knew performing was, more than anything, what he wanted to do.

He says, "I am a person who is ambitious. I'm ambitious to get the very best from every moment and even if that's just taking my children to the zoo ... I want it to be the best it can be.".

Kirsty Young's castaway is the Right Honourable Theresa May MP - the longest serving Home Secretary in fifty years.

For those who think her political lineage seems directly descended from the Iron Lady, Theresa May's metal has certainly been stress-tested in the past few weeks. She's apologised twice in parliament for having failed to appoint a suitable head to lead the historical child abuse inquiry; a minister in her department resigned, claiming working with her had been like "walking through mud". Then there has been the controversy over the non-vote on the European Arrest Warrant and finally news this week that 1 in 5 crimes are unrecorded.

Just as well that she has a reputation as a woman who knows her own mind and is willing to speak it. She famously said the Conservatives were perceived as the 'nasty party'. Her excoriating speech to the Police Federation dealt head on with long-term corruption and incompetence in their ranks and was received with stunned silence.

So unflinching, resilient, driven and, if a recent poll is to be believed, a popular choice among Conservative voters to be the next Prime Minister. She has, so far, remained tight-lipped on any ambition to lead her party.

She says, "I think you have to believe in what you're doing - that's key. If you do believe you are doing the right thing - that gives you resilience".

Kirsty Young's castaway this week is the poet John Agard.

His work is studied widely in British schools. He was the BBC's first poet in residence and along with WH Auden and Philip Larkin, he's a recipient of The Queen's Gold Medal for Poetry.

Born in Guyana he arrived here in the mid-1970s already playing with words like some people play with musical notes. If his style is often satirical, his subjects provide wincing realism - examining the scars of slavery or the historical myopia of a shared past judged solely through European eyes.

He says he believes that "the poet keeps us in touch with the vulnerable core of language that makes us what we are."

Producer: Cathy Drysdale.

Kirsty Young's guest is former Royal Navy test pilot Captain Eric 'Winkle' Brown - the programme's 3000th edition.

The Fleet Air Arm's most decorated pilot, his life reads like a handbook in beating the odds.

Landing on a flight deck is acknowledged as one of the most difficult things a pilot can do. Eric Brown has held the world record for the most flight deck landings - 2,407 - for over 65 years. He was one of only two men on his ship, HMS Audacity, to survive a German U-boat bombing.

In a long and remarkable life he has witnessed first-hand momentous events in world history, from the Berlin Olympics in 1936 to the liberation of the Belsen concentration camp.

Flying, he believes, is in his blood. He originally climbed into the open cockpit of a Gloster Gauntlet as a child to sit on his father's knee. Thirty years later he would pilot Britain's first ever supersonic flight.

He says: "It's an exhilarating world to live in. There's always that aura of risk - you come to value life in a slightly different way."

Producer: Paula McGinley.

Kirsty Young's castaway this week is the fashion designer, Professor Wendy Dagworthy.

During her time as Head of Fashion at both Central St Martins and The Royal College of Art she has taught students who've gone on to great success - Stella McCartney, Erdem and Antonio Berardi among them. Her skill lies partly in understanding the significance of a well cut pattern or a nicely turned seam, but also the warp and weft of a notoriously fickle industry.

At just 23, she was the toast of the catwalks with her own label selling round the world and worn by the likes of Bryan Ferry, Boy George and Mick Jagger. Dubbed 'the high priestess of fashion', her creative talent, however, wasn't recession-proof and her business went under in the late 80's. Given that reinvention is the lifeblood of fashion it seems she was tailor made for a new direction; collecting her O.B.E. in 2011 for services to the fashion industry, she wore a Perspex hat designed by a former pupil.

She says, "we want students to take risks - like we did when we were younger. There were no set rules, there was no one to follow - you just did it yourself."

Producer: Cathy Drysdale.