DrBeen#28 Spike Proteins Disrupt Nitric Oxide

Let's review how the spike protein alone can cause dysregulation of the ACE2 bearning cells. One important mechanism is the reduction in the expression of the endothelial nitric oxide synthase (eNOS) enzyme. Let's review.

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

URL list from Sunday, Oct. 9 2022

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2 | Circulation Research
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318902

Mitochondrial Dynamics in SARS-COV2 Spike Protein Treated Human Microglia: Implications for Neuro-COVID - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487226/

Endothelial NOS - Wikipedia
https://en.wikipedia.org/wiki/Endothelial_NOS

The novel coronavirus’ spike protein plays additional key role in illness - Salk Institute for Biological Studies
https://www.salk.edu/news-release/the-novel-coronavirus-spike-protein-plays-additional-key-role-in-illness/

ACE/ACE2 balance might be instrumental to explain the certain comorbidities leading to severe COVID-19 cases - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856554/

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820157/

Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients - eBioMedicine
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00077-9/fulltext

l-Arginine and COVID-19: An Update - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619186/

l-Arginine supplementation enhances eNOS expression in experimental model of hypercholesterolemic rabbits aorta - PubMed
https://pubmed.ncbi.nlm.nih.gov/19168337/

Implications of SARS-Cov-2 infection on eNOS and iNOS activity: Consequences for the respiratory and vascular systems - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S1089860321000380

Induction of citrulline-nitric oxide (NO) cycle enzymes and NO production in immunostimulated rat RPE-J cells - PubMed
https://pubmed.ncbi.nlm.nih.gov/12589771/

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