DrBeen#29 How Spike Protein Causes Pathologies in Our Tissues and Vessels

In this discussion we will go over the important pathologic mechanisms behind the diseases caused by the spike protein.

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

URL list from Friday, Oct. 21 2022

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies | Acta Pharmacologica Sinica
https://www.nature.com/articles/s41401-022-00998-0

Frontiers | SARS-CoV-2 Spike Protein Induces Degradation of Junctional Proteins That Maintain Endothelial Barrier Integrity
https://www.frontiersin.org/articles/10.3389/fcvm.2021.687783/full

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2 | Circulation Research
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318902

Mitochondrial Dynamics in SARS-COV2 Spike Protein Treated Human Microglia: Implications for Neuro-COVID - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487226/

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820157/

IJMS | Free Full-Text | New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease | HTML
https://www.mdpi.com/1422-0067/20/1/187/htm

Molecular mimicry and autoimmunity - PubMed
https://pubmed.ncbi.nlm.nih.gov/30509385/

Endothelial NOS - Wikipedia
https://en.wikipedia.org/wiki/Endothelial_NOS

ACE/ACE2 balance might be instrumental to explain the certain comorbidities leading to severe COVID-19 cases - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856554/

Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients - eBioMedicine
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00077-9/fulltext

l-Arginine and COVID-19: An Update - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619186/

l-Arginine supplementation enhances eNOS expression in experimental model of hypercholesterolemic rabbits aorta - PubMed
https://pubmed.ncbi.nlm.nih.gov/19168337/

Implications of SARS-Cov-2 infection on eNOS and iNOS activity: Consequences for the respiratory and vascular systems - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S1089860321000380

Induction of citrulline-nitric oxide (NO) cycle enzymes and NO production in immunostimulated rat RPE-J cells - PubMed
https://pubmed.ncbi.nlm.nih.gov/12589771/

Oct 21, 2022 at 4:58 PM
Oxidative Stress, Nitric Oxide Synthase, and Superoxide Dismutase
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.107.103226

Oct 21, 2022 at 5:09 PM
Critical Role of the Nitric Oxide/Reactive Oxygen Species Balance in Endothelial Progenitor Dysfunction
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135185/

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

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