DrBeen#58 MTHFR Gene Mutation and the Risk of Clotting

In the United States, 20-40% of whites and hispanics have MTHFR gene mutation (C677T). This mutation leads to reduced function of MTHFR enzyme to 65% of normal. The second most common mutation leads to reduced function of MTHFR enzyme, to 30% of normal.

The result of these performance issues is reduced methyl groups' availability for methylation functions. The likelihood of clotting in the cardiovascular system increases because of the endothelial impaired function, clotting factor abnormalities, and increased levels of reactive oxygen species (ROS).

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

URL list from Tuesday, June 6, 2023

Homocysteine and MTHFR Mutations | Circulation
https://www.ahajournals.org/doi/10.1161/circulationaha.114.013311

preprints202303.0418.v2.pdf
file:///C:/Users/s_mob/Downloads/preprints202303.0418.v2.pdf

Folate, MTHFR Gene and Heart Health
https://www.gbhealthwatch.com/GND-Cardiovascular-Diseases-MTHFR.php

Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564482/

Frontiers | Prognostic Genetic Markers for Thrombosis in COVID-19 Patients: A Focused Analysis on D-Dimer, Homocysteine and Thromboembolism
https://www.frontiersin.org/articles/10.3389/fphar.2020.587451/full

Methylenetetrahydrofolate Reductase Deficiency - Medical Genetics Summaries - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK66131/

Contribution of genotypes in Prothrombin and Factor V Leiden to COVID‐19 and disease severity in patients at high risk for hereditary thrombophilia - Kiraz - 2023 - Journal of Medical Virology - Wiley Online Library
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.28457

Do MTHFR polymorphisms make you more susceptible to COVID-19? - MTHFR Support Australia
https://mthfrsupport.com.au/2021/08/do-mthfr-polymorphisms-make-you-more-susceptible-to-covid-19/

Acute Macular Neuroretinopathy Associated With COVID-19 Infection: Is Double Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutation an Underlying Risk Factor? - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968507/

Methylenetetrahydrofolate reductase - Wikipedia
https://en.wikipedia.org/wiki/Methylenetetrahydrofolate_reductase

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