In this review of research, we find that SARS-COV-2 (possibly directly) and COVID-19 vaccines (possibly indirectly, via anti-idiotype antibodies) can change the neuron gene expressions in the sensory ganglions. Additionally, there is a possibility of ganglion pathology due to peripheral nerve injury and systemic inflammatory molecules in the circulation. Satellite glial cells, macrophages, and other immune cells could become activated in the ganglions resulting in neuronal hyperexcitability and hyperesthesia and allodynia. Let's review.

URL list from Thursday, Nov. 30, 2023

Neuropathic Pain Associated with COVID-19: a Systematic Review of Case Reports | Current Pain and Headache Reports
https://link.springer.com/article/10.1007/s11916-022-01065-3

Functional Anatomy of the Sensory Nervous System: Updates From the Neuroscience Bench - LaTasha K. Crawford, Michael J. Caterina, 2020
https://journals.sagepub.com/doi/10.1177/0192623319869011

Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513227/

SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model | Science Signaling
https://www.science.org/doi/10.1126/scisignal.ade4984

Neuropathic symptoms with SARS-CoV-2 vaccination - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128783/

How Is Peripheral Injury Signaled to Satellite Glial Cells in Sensory Ganglia? - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833977/

Neuron-associated macrophage proliferation in the sensory ganglia is associated with peripheral nerve injury-induced neuropathic pain involving CX3CR1 signaling | eLife
https://elifesciences.org/articles/78515

Neuropathic Pain: From Mechanisms to Treatment | Physiological Reviews
https://journals.physiology.org/doi/full/10.1152/physrev.00045.2019

ILF3 - Wikipedia
https://en.wikipedia.org/wiki/ILF3

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.