Early-onset gastrointestinal cancers, typically defined as occurring in patients younger than age 50, are increasing worldwide. A recent JAMA Review summarizes current data on early-onset colorectal, pancreatic, and esophagogastric cancers. Coauthor Kimmie Ng, MD, MPH, of Dana-Farber Cancer Institute joins JAMA Deputy Editor Kristin Walter, MD, MS to discuss. Related Content:

• Early-Onset Gastrointestinal Cancers
• Screening for Helicobacter pylori to Prevent Gastric Cancer
• First-Line Sugemalimab Plus Chemotherapy for Advanced Gastric Cancer

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JAMA Editors' Summary