For our 63rd episode, we returned to the Endocrine Society’s annual meeting and recorded before a live audience at ENDO 2025 in San Francisco. We look at a study from that suggests that we can substantially alter our diagnostic approach to adrenal insufficiency. This study and others have already led to a shift in recommendations from some experts, so we thought it would be of great interest to you all as our listeners. Host Chase Hendrickson, MD, from Vanderbilt University talks with regular contributor Katie Guttenberg, MD, from the University of Texas Health Science Center at Houston, and guest expert Anand Vaidya, MD, from Brigham and Women’s Hospital and Harvard Medical School in Boston. They discuss “Performance of Dehydroepiandrosterone Sulfate and Baseline Cortisol in Assessing Adrenal Insufficiency” by Han et al, first published online in JCEM in December 2024. We have four senior fellows joining us to help analyze the article. They each submitted questions in advance, and we called on them throughout the episode to ask those questions. Those fellows are Natalia Fretes Oviedo, MD, from the Cleveland Clinic; Nikola Gligorijevic, MD, from the University of Pittsburgh; Rinki Pandya, MD, from Oregon Health & Science University; and Aye Khine, MD, from University of California San Francisco. Show notes can be found at https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series/efl063 — podcast home page: https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series