For our 66th episode, we review a recent article that looks at the frequency of positive islet antibodies in a population of adults without diabetes. While that may initially seem like an unusual article choice, we found it to be quite helpful in an era where we now have a therapeutic option to delay the onset of clinical type 1 diabetes when we can identify people early enough. That treatment option naturally raises questions about how we can find such patients and the risk of false-positive results with these antibodies. Host , from Vanderbilt University talks with regular contributor , from the University of Rochester Medical Center, and guest expert , from the University of Chicago. They discuss by Pauley et al, published in the August 2025 issue of JES. Show notes can be found at — podcast home page: .