Levothyroxine (T4-only therapy) has long been the standard treatment for hypothyroidism. However, many patients continue to experience persistent symptoms such as fatigue, brain fog, weight gain, and depression—even when their lab results appear "normal." Could adding T3—the active thyroid hormone—be the key to feeling better?

In this episode, we take a comprehensive look at T3-inclusive treatment options, including natural desiccated thyroid (NDT) and synthetic combination therapies that contain both T4 and T3. We'll review recent research comparing the effectiveness of T4-only versus combination therapies, discuss patient-reported outcomes, and examine the growing interest in individualized thyroid care.

You'll also hear about the real-world challenges patients face when seeking T3-based treatment—such as resistance from providers, limited access to prescriptions, and cost concerns. We’ll share expert-backed advice and practical tips for advocating for your care, finding informed healthcare providers, and accessing affordable T3 medications safely.

Whether you're newly diagnosed or still struggling with symptoms on levothyroxine, this episode from Paloma Health offers critical insights into whether a T3-inclusive approach may be right for you.

Need more information? 

Learn more at the Paloma Health blog:

Should Your Hypothyroidism Treatment Include T3?

https://www.palomahealth.com/learn/t3-treatment-hypothyroidism 

T3 Thyroid Medication: The Most Comprehensive Overview

https://www.palomahealth.com/learn/t3-thyroid-medication-overview 

What Is Cytomel Thyroid Medication?

https://www.palomahealth.com/learn/cytomel-thyroid-medication 

Low Free T3 and Cognitive Impairment

https://www.palomahealth.com/learn/low-free-t3--cognitive-impairment 

Levothyroxine vs. Natural Desiccated Thyroid Medication

https://www.palomahealth.com/learn/levothyroxine-vs-desiccated-thyroid 

Normal Is Not Optimal

https://www.palomahealth.com/learn/normal-thyroid-may-not-be-optimal 

About Paloma Health:

⁠⁠Paloma Health ⁠⁠⁠⁠⁠⁠⁠⁠is an online medical practice focused exclusively on treating hypothyroidism. From online visits with your provider to easy prescription management and lab orders, we create personalized treatment plans for you. 

Become a member⁠, or try our at-home test kit and experience a whole new level of hypothyroid care. Use code PODCAST to save $30 at checkout.

Disclaimer: The $30 discount is only valid for first-time Paloma Health members and test kit users. Coupon must be entered at the time of checkout. 

Become a Paloma Member:

https://www.palomahealth.com/pricing-hypothyroidism 

Paloma Complete Thyroid Blood Test Kit:

https://www.palomahealth.com/home-thyroid-blood-test-kit