In this episode of the Thyroid Pharmacist Healing Conversations podcast, Dr. Izabella Wentz interviews researcher and Clarisen (formerly Science Mama’s HQ) co-founder Alexandra Karpova, whose personal health challenges – and her children’s struggles with mast cell activation, thyroid symptoms, chronic fatigue, and sensory issues – led her to discover the critical role of functional nutrient deficiencies in chronic illness. Alexandra shares her research on how impaired metabolic pathways, detoxification issues, childhood nutrient depletion, environmental triggers, and poor nutrient activation can create symptoms of thyroid dysfunction even when lab tests look normal.

Together, they explore the surprising connections between riboflavin, sulfation pathways, histamine intolerance, autism spectrum symptoms, mitochondrial health, and thyroid metabolism. Alexandra also discusses the emerging science behind transdermal nutrient delivery, which may offer new solutions for children and adults who can’t tolerate or absorb oral supplements.

What you’ll learn in this episode:

Many thyroid symptoms come from deeper metabolic issues, not just the thyroid itself. Alexandra explains how impaired detoxification (like sulfation or glucuronidation), mitochondrial dysfunction, or functional nutrient deficiencies can mimic hypothyroidism – even when lab tests appear normal. These hidden blocks may lead to fatigue, temperature swings, mood changes, and sensory symptoms in both adults and children.

Functional nutrient deficiencies often don’t appear on standard blood tests. Alexandra shares how nutrients such as B2, B6, iodine, selenium, and molybdenum may be present in the bloodstream but not utilized well by cells due to poor gut function, low stomach acid, inflammation, or impaired liver pathways. This helps explain why symptoms persist despite “normal labs.”

Children with autism, sensory issues, or mast cell activation may have underlying metabolic disruptions. Alexandra’s story highlights how addressing nutrient imbalances, gut health, and thyroid hormone activation can support dramatic improvements in sleep, sensory processing, allergic reactions, and social and cognitive development.

Topical (transdermal) nutrients may be game-changing for kids and adults with poor gut absorption. Alexandra describes how transdermal B2, iodine, and selenium bypass gut inflammation and low stomach acid, leading to faster improvements in energy, mood, and metabolic stability – especially for children who struggle with oral supplements.

Histamine intolerance, anxiety, eczema, and food reactions often have biochemical root causes. B2-dependent enzymes (like DAO), infections (like H. pylori), mold, poor detox pathways, and nutrient deficiencies can drive histamine overload. Supporting these pathways can dramatically reduce symptoms like anxiety, sensory overload, and skin symptoms.

There is hope – and simple, targeted strategies can improve complex chronic symptoms. Alexandra outlines small, consistent changes parents can make to reduce overwhelm, support metabolism, and gradually rebuild health in themselves and their children.

Tune in to learn more about how nutrition, biochemistry, and metabolic support can transform thyroid health for both children and adults.

Be sure to subscribe to the Thyroid Pharmacist Healing Conversations podcast so you don’t miss an episode! Sign up for the Thyroid Pharmacist Weekly Thyroid Solutions Newsletter here: https://thyroidpharmacist.com/gift/ 

For the full list of resources and products mentioned in this episode, and to get the full episode transcript, see complete show notes here: https://thyroidpharmacist.com/articles/podcast/

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In this episode of Thyroid Pharmacist Healing Conversations, Dr. Izabella Wentz interviews Dr. Trevor Cates – author, naturopathic doctor, and founder of The Spa Dr. skincare and supplement line – about the intimate links between hormones, skin, and hair. Together, they explore how perimenopause, thyroid dysfunction, and toxic skincare products affect women’s health inside and out.

Listeners will gain insight into the role of bioidentical hormones, clean skincare, nutrient-rich foods, and targeted supplements in promoting healthy aging. Dr. Cates also shares her clinical experience with hair loss, the importance of addressing root causes, and how natural approaches can bring harmony back to the body.

What you’ll learn in this episode:

Perimenopause reveals hidden imbalances. Symptoms like insomnia, night sweats, palpitations, and anxiety can feel overwhelming, but they are signs of underlying root causes – like gut dysbiosis or nutritional deficiencies – that often resurface during this time of transition.

Hormones and skin are deeply connected. Fluctuations in estrogen, progesterone, testosterone, and cortisol can cause acne, premature aging, and sagging skin. Instead of masking symptoms, Dr. Cates emphasizes root-cause healing through nutrition, stress reduction, and hormone balance.

Skincare toxins can disrupt hormones. Many conventional products contain endocrine disruptors that are absorbed through the skin and contribute to estrogen dominance, thyroid dysfunction, and other imbalances. Choosing clean, pH-balanced, and microbiome-friendly products is key.

Hair loss isn’t just about the thyroid. While hypothyroidism is a common cause, other root triggers include low ferritin, high DHT, stress, medications, and infections. Addressing these drivers while supporting hair externally can promote regrowth and resilience.

Inside-out and outside-in approaches create lasting beauty. Anti-inflammatory foods, antioxidants, collagen, and gut health practices work synergistically with topical skincare and haircare products to maintain healthy, glowing skin and strong hair.

Supplements and botanicals can ease perimenopause. Formulas with Vitex (chaste tree), black cohosh, dong quai, and saw palmetto can help with brain fog, mood changes, and hair loss related to shifting hormones.

Be sure to subscribe to the Thyroid Pharmacist Healing Conversations podcast so you don’t miss an episode! Sign up for the Thyroid Pharmacist Weekly Thyroid Solutions Newsletter here: https://thyroidpharmacist.com/gift/ 

For the full list of resources and products mentioned in this episode, and to get the full episode transcript, see complete show notes here: https://thyroidpharmacist.com/articles/podcast/

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In this episode of Thyroid Pharmacist Healing Conversations, Dr. Izabella Wentz interviews Dr. Rajsree Nambudripad, founder of OC Integrative Medicine in Orange County, CA, who specializes in treating gut disorders through an integrative lens.

Dr. Rajsree shares her personal journey with SIBO and how it inspired her to develop a comprehensive four-phase protocol addressing motility, digestion, inflammation, and microbial balance. Together, she and Dr. Wentz explore how SIBO impacts hypothyroidism, why many reflux cases stem from low stomach acid, and how to restore gut health without endless food restrictions or antibiotic cycles.

What you’ll learn in this episode:

Why so many thyroid patients have SIBO. Up to 50% of people with hypothyroidism test positive for small intestinal bacterial overgrowth. Slower gut motility, low stomach acid, and reduced bile and enzyme output make it easier for bacteria to overgrow in the small intestine – and this is why so many thyroid patients struggle with bloating, reflux, and food reactions.

How SIBO mimics other gut issues. Bloating, food sensitivities, histamine intolerance, and acid reflux often stem from SIBO, but the underlying issue isn’t “too much acid” or “bad foods” – it’s misplaced bacteria in the small intestine damaging enzymes and inhibiting absorption.

Dr. Rajsree’s four-step SIBO protocol. Discover the clear, phased protocol that supports motility, reduces gas and irritation, calms inflammation, and gently clears the overgrowth without overwhelming your system. 

Why conventional SIBO treatments fall short. Antibiotics and low-FODMAP diets may help temporarily, but without fixing motility and healing the gut lining, symptoms almost always return. A comprehensive approach reduces relapse and supports long-term gut health.

The thyroid-SIBO connection. Low T3 slows the migrating motor complex, the gut’s natural “cleaning wave.” Fine-tuning thyroid medication or even adding a small amount of T3 support can improve motility and make SIBO recovery easier and more effective.

Why reflux is often caused by too little stomach acid, not too much: Many people with Hashimoto’s actually have low stomach acid levels. Acid-suppressing medications can worsen nutrient deficiencies and create the perfect conditions for SIBO. Supporting digestion with betaine HCl and enzymes often reduces bloating and reflux far more effectively than PPIs.

Be sure to subscribe to the Thyroid Pharmacist Healing Conversations podcast so you don’t miss an episode! Sign up for the Thyroid Pharmacist Weekly Thyroid Solutions Newsletter here: https://thyroidpharmacist.com/gift/ 

For the full list of resources and products mentioned in this episode, and to get the full episode transcript, see complete show notes here: https://thyroidpharmacist.com/articles/podcast/

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In this episode of the Thyroid Pharmacist Healing Conversations podcast, Dr. Izabella Wentz interviews Alice McDonnell, founder of the Hashimoto’s 411 community, the largest autoimmune thyroid support group, and the first to focus on the autoimmune roots of Hashimoto’s. She is also the creator of the Autoimmune 411 community and Academy. 

Drawing on two decades of advocacy, Alice shares why the healing sequence matters, how to cut through today’s noisy wellness feeds, and the foundations that help any protocol work better – without the setbacks.

We explore iodine, LDN, and peptides, diet frameworks without dogma, and practical stories that save patients from learning the hard way. This is a grounded reset for anyone overwhelmed by conflicting advice about autoimmune conditions like Hashimoto’s.

What you’ll learn in this episode:

Why sequence is everything. Alice explains how jumping straight into detox (or any “advanced” protocol) without opening drainage pathways and stabilizing the nervous system can backfire – sometimes for months – while a stepwise approach creates steady progress and fewer flares.

How to navigate the info-storm. Reels and algorithms don’t equate to your unique healing plan. Not all wellness hacks may be appropriate for you. Remember to use a simple lens, considering context, bio-individuality, and timing, to stop doomscrolling through internet noise, and get to your own root cause.

The foundational four to make protocols “stick.” Nervous system regulation, limbic retraining, lymphatic flow, and fascia support are the base layers that help diets, supplements, and detox actually work (and get you feeling better).

Iodine, LDN, and peptides pros, cons, and prerequisites. From selenium status and iodine timing, to why LDN helps some and not others, to BPC-157 observations – learn the nuances that turn “it depends” into a personal plan.

Diet without dogma. The Autoimmune Paleo (AIP) Diet can be game-changing, but it isn’t the only path. Alice discusses Mediterranean, Whole30-style, low-histamine, and GAPS-inspired approaches, plus when to pause eliminations and evaluate deeper triggers like stress, infections, or mold.

Real-world cautionary tales. We share stories on DIY colon cleanses, poorly timed chelation, and even “healthy” spirulina gone wrong, and how to protect yourself with education, labs, and sequence – so you don’t have to learn the hard way!

Be sure to subscribe to the Thyroid Pharmacist Healing Conversations podcast so you don’t miss an episode! Sign up for the Thyroid Pharmacist Weekly Thyroid Solutions Newsletter here: https://thyroidpharmacist.com/gift/ 

For the full list of resources and products mentioned in this episode, and to get the full episode transcript, see complete show notes here: https://thyroidpharmacist.com/articles/podcast/

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In this episode of Thyroid Pharmacist Healing Conversations, Dr. Izabella Wentz interviews gallbladder and fatty liver nutritionist Olivia Haas about the connection between bile flow, liver health, and thyroid function. They cover early red flags (like pale, “sticky” stools and nausea after fats), when low-fat makes sense (and when it doesn’t), and practical ways to stimulate bile gently with bitters, minerals, and targeted supplements. They also discuss various testing methods and a step-by-step approach to optimal digestive health for those with and without gallbladders.

What you’ll learn in this episode:

Fat intolerance is a bile story – start with flow. Nausea after fatty meals, reflux, and pale, sticky, or floating stools point to sluggish bile. Instead of staying low-fat forever, Olivia explains how to gently improve bile composition and flow so you can digest fats again.

Bitters are a simple first step. Radicchio, dandelion (tea or greens), lemon water, and diluted apple cider vinegar can quickly nudge bile flow and ease fat sensitivity, especially when used before meals. Olivia shares when to start bitters, how often, and how to scale up safely.

The thyroid–gallbladder loop runs both ways. Low thyroid can thicken bile (cholesterol supersaturation) and weaken gallbladder contraction (low CCK), while poor bile flow can impair T4-to-T3 conversion and raise toxin burden – fueling a vicious cycle.

Fatty liver is common, and reversible when you catch it early. Don’t wait for elevated liver enzymes. Patterns like high triglycerides, low HDL, insulin resistance, fatigue, 3 a.m. wake-ups, clay-colored stools, and PMS can flag trouble earlier and justify an ultrasound/FibroScan.

Post-cholecystectomy? You still need a plan. Without the gallbladder’s “regulator,” bile can drip constantly and irritate the gut – or be too weak to digest fats. Olivia’s priorities: individualized digestive support (enzymes/bile salts/ACV), mineral repletion, fiber, and steady liver support.

Myth-busting time. “Low-fat forever saves your gallbladder” (it doesn’t), “you can eat anything after surgery” (please don’t), and “it’s just genetics” (choices and exposures turn genes on) all miss the bigger picture of bile flow, metabolism, and toxins.

Be sure to subscribe to the Thyroid Pharmacist Healing Conversations podcast so you don’t miss an episode! Sign up for the Thyroid Pharmacist Weekly Thyroid Solutions Newsletter here: https://thyroidpharmacist.com/gift/ 

For the full list of resources and products mentioned in this episode, and to get the full episode transcript, see complete show notes here: https://thyroidpharmacist.com/articles/podcast/

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In this episode of Thyroid Pharmacist Healing Conversations, Dr. Izabella Wentz interviews Dr. Ann Shippy, an integrative physician and former engineer who has become a leader in functional medicine and environmental health. Dr. Shippy discusses how toxins, genetics, and nutrient status can shape fertility, pregnancy outcomes, and even the long-term health of future generations. Listeners will discover practical, science-based strategies to reduce toxic exposures, restore the body’s natural detoxification systems, and prepare for healthy conception and pregnancy – even later in life.

What you’ll learn in this episode:

Why preconception health matters for every family. The six to twelve months before conception are a key window to influence fertility, pregnancy outcomes, and a child’s lifelong health. Dr. Ann Shippy explains how both parents’ nutrition, toxin exposure, and stress can shape DNA expression, and how small changes can support healthy conception.

The overlooked role of toxins in chronic illness. Mold, heavy metals, plastics, and household chemicals can quietly affect hormones and immune balance. Dr. Shippy shares common environmental exposures she sees in her patients and how testing, detoxification, and lifestyle shifts can help restore balance.

How genetics and epigenetics shape our resilience. Your DNA isn’t your destiny. Dr. Shippy explains how nutrients such as methylated B vitamins, folate, and choline can support methylation, helping “turn on” genes that promote health and silence those linked to disease.

The critical link between gut health and detoxification. A healthy gut microbiome helps clear toxins, balance hormones, and support fertility. Dr. Shippy outlines ways to strengthen gut and liver detox pathways naturally with binders, glutathione, and key nutrients.

How to create a toxin-free home and pregnancy plan. From air and water filtration to safer personal care and cleaning products, Dr. Shippy offers realistic ways to minimize toxic load and protect both parents and developing babies.

Be sure to subscribe to the Thyroid Pharmacist Healing Conversations podcast so you don’t miss an episode! Sign up for the Thyroid Pharmacist Weekly Thyroid Solutions Newsletter here: https://thyroidpharmacist.com/gift/ 

For the full list of resources and products mentioned in this episode, and to get the full episode transcript, see complete show notes here: https://thyroidpharmacist.com/articles/podcast/

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In this episode of Thyroid Pharmacist Healing Conversations, Dr. Izabella Wentz interviews Josh Dech, a holistic nutritionist and digestive health expert who is challenging the conventional medicine narrative around Crohn’s disease and colitis. Gut symptoms are common for those with Hashimoto’s and thyroid disease, and they often have similar root causes, including inflammation, food sensitivities, microbiome imbalances, and toxins. Josh reveals why the mainstream approach often fails patients, and how natural strategies and “root cause” thinking can lead to remission and, in some cases, even recovery.

What you’ll learn in this episode:

Why the conventional view of Crohn’s and colitis may be flawed. Standard approaches often focus on suppressing symptoms with medications or recommending surgery when things progress, but they rarely ask why inflammation is happening in the first place. Josh explains how this limited model leaves many people dependent on treatments that don’t provide long-term solutions.

The hidden drivers of gut inflammation. Crohn’s and colitis rarely happen “out of nowhere.” Josh explains how food sensitivities, microbiome imbalances, toxins, and immune dysregulation often interact to create chronic inflammation, and how identifying your personal triggers can open the door to remission.

The role of nutrition in calming the gut. Instead of fearing food, Josh shows how the right diet can calm the immune system and repair the gut lining. When nutrition is used strategically – removing irritants and rebuilding with nutrient-dense foods – the body often heals more effectively than it does on medication alone.

Real stories of reversal and recovery. Hundreds of Josh’s clients have defied expectations – moving from flare-ups and medication dependence to full, symptom-free lives. Their results show that Crohn’s and colitis aren’t life sentences, but conditions that can improve dramatically when you heal from the inside out.

Be sure to subscribe to the Thyroid Pharmacist Healing Conversations podcast so you don’t miss an episode! Sign up for the Thyroid Pharmacist Weekly Thyroid Solutions Newsletter here: https://thyroidpharmacist.com/gift/ 

For the full list of resources and products mentioned in this episode, and to get the full episode transcript, see complete show notes here: https://thyroidpharmacist.com/articles/podcast/

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In this episode of Thyroid Pharmacist Healing Conversations, Dr. Izabella Wentz speaks with integrative cardiologist Dr. Jack Wolfson about how heart health goes far beyond lab numbers. They discuss why thyroid issues and nutrient deficiencies can trigger palpitations, why cholesterol isn’t the villain it’s made out to be, and how lifestyle factors like sleep, sunlight, nutrition, and reducing toxins, can naturally support cardiovascular wellness.

What you’ll learn in this episode:

Why palpitations may be a message from your body: Heart flutters often reflect deeper imbalances like thyroid dysfunction, iron or magnesium deficiency, or toxin exposure. Dr. Wolfson explains how addressing the root cause can calm the heart and restore balance naturally.

Why cholesterol is not the villain we’ve been told. Cholesterol is essential for hormone production, cell membranes, and vitamin D synthesis. Elevated cholesterol is often a sign of other imbalances such as thyroid dysfunction, liver congestion, or nutrient deficiencies, not a statin deficiency.

When “conventional” treatments miss the mark: Statins and blood pressure drugs may improve numbers but overlook root causes such as adrenal stress, nutrient depletion, and toxin overload. Dr. Wolfson shares how true healing begins with rebalancing the body.

The heart-healing power of lifestyle medicine: Sunlight, sleep, nutrient-rich food, movement, and emotional healing are powerful heart supports. Even daily sun exposure can boost vitamin D, nitric oxide, and melatonin for better blood pressure and sleep.

The overlooked connection between your mouth, gut, and heart: Periodontal disease, leaky gut, and microbiome imbalance can fuel inflammation that affects both thyroid and heart function. Discover how holistic dental care and gut healing can protect your cardiovascular system.

Supplements and natural supports that work. Nutrients like beet root, L-arginine, grape seed extract, CoQ10, carnitine, and omega-3s can improve circulation, support mitochondria, and optimize heart and thyroid function.

Be sure to subscribe to the Thyroid Pharmacist Healing Conversations podcast so you don’t miss an episode! Sign up for the Thyroid Pharmacist Weekly Thyroid Solutions Newsletter here: https://thyroidpharmacist.com/gift/ 

For the full list of resources and products mentioned in this episode, and to get the full episode transcript, see complete show notes here: https://thyroidpharmacist.com/articles/podcast/

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In this solo episode, Dr. Izabella Wentz shares the turning point that shifted her Hashimoto’s recovery: discovering that “acid reflux” can stem from low stomach acid (hypochlorhydria) rather than excess stomach acid, as many believe. She explains how hypochlorhydria drives fatigue, brain fog, pain, nutrient deficiencies, SIBO/H. pylori risk, and why supporting digestion can restore energy and clarity fast.

She outlines a practical betaine HCl + pepsin titration, who should avoid it, and simple daily upgrades (like mindful meals, lemon water or diluted ACV, bitters, and thiamine). Real-world response rates and safety notes are included.

What you’ll learn in this episode:

Why “acid reflux” can actually mean low stomach acid. In hypothyroidism, stomach acid often runs low, which impairs protein breakdown, fuels overgrowths, increases ammonia (hello brain fog), and leaves you tired after meals. Understanding this flips the usual reflux narrative and opens a path to real relief.

How low acid drives fatigue, pain, and mood changes. Poor protein digestion means fewer amino acids for neurotransmitters and repair; when you add in nutrient gaps (B12, iron/ferritin) and inflammatory byproducts, you’ve got a perfect storm for low energy, aches, and low mood.

A step-by-step guide to finding your ideal betaine HCl + pepsin dose at meals. Dr. Wentz shares how to determine how many capsules would be most suitable for you, and how to use it safely for best results.

When to pause or avoid HCl. It’s not for everyone: if you have active or past peptic ulcers, confirmed H. pylori, current acid overproduction, ingredient sensitivities, or chronic NSAID/steroid use, if you use ongoing PPIs (or you’re weaning), or if you are pregnant/breastfeeding, talk to your clinician first.

Simple daily upgrades to raise digestive fire. Eating in a calm state, chewing well, trying diluted lemon water or apple cider vinegar with meals, considering digestive bitters, and assessing thiamine can be surprising helpers for stomach acid and thyroid fatigue.

Real-world outcomes and what to expect. In Dr. Wentz’s experience, ~60% of people feel better on HCl, ~33% don’t tolerate it, and ~7% feel no change. Wins often include more energy, less pain/bloating, better mood, smoother bowels, and easier weight balance when digestion finally “clicks.”

Be sure to subscribe to the Thyroid Pharmacist Healing Conversations podcast so you don’t miss an episode! Sign up for the Thyroid Pharmacist Weekly Thyroid Solutions Newsletter here: https://thyroidpharmacist.com/gift/ 

For the full list of resources and products mentioned in this episode, and to get the full episode transcript, see complete show notes here: https://thyroidpharmacist.com/articles/podcast/

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In this episode of Thyroid Pharmacist Healing Conversations, Dr. Izabella Wentz interviews gut health expert Steven Wright, founder of Healthy Gut. Steven shares his 15-year healing journey and explains why restrictive elimination diets often fail to resolve the root causes of digestive distress. Together, they explore how low stomach acid, SIBO, histamine overload, and stress contribute to food sensitivities – and how to build a more resilient gut that allows for food freedom.

What you’ll learn in this episode:

Why endless food elimination often backfires. While cutting out certain foods can help in the short term, staying overly restrictive can harm the microbiome, create nutrient deficiencies, and worsen food reactions over time. Healing requires more than just “the perfect diet.”

The overlooked role of stomach acid in gut health. Low stomach acid is common in people with Hashimoto’s and can drive SIBO, reflux, nutrient deficiencies, and ongoing inflammation. Steven explains how simple HCl support can restore digestion, energy, and overall resilience.

How histamine intolerance fuels food sensitivities. Symptoms like headaches, rashes, diarrhea, anxiety, or migraines can stem from histamine overload. Steven and Dr. Wentz discuss how mast cells, DAO enzymes, and butyrate help calm inflammation and support histamine tolerance.

Why probiotics and prebiotics aren’t enough on their own. A healthy gut requires proper digestion, enzymes, and microbial balance. Butyrate and brush border enzymes may be the missing link in rebuilding tolerance to plants and fibers.

Stress, the nervous system, and digestion. Even a perfect diet and supplements won’t work if you’re stuck in “fight-or-flight” mode. Discover practical ways to support your parasympathetic nervous system and adrenals, so your body can be in a state of healing.

Be sure to subscribe to the Thyroid Pharmacist Healing Conversations podcast so you don’t miss an episode! Sign up for the Thyroid Pharmacist Weekly Thyroid Solutions Newsletter here: https://thyroidpharmacist.com/gift/ 

For the full list of resources and products mentioned in this episode, and to get the full episode transcript, see complete show notes here: https://thyroidpharmacist.com/articles/podcast/

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