What if one of the most “lifelong” medications in medicine… isn’t always meant to be lifelong? 

In this eye-opening episode of the Paloma Health podcast, we unpack the provocative findings of the 2026 RELEASE trial—and the question millions of people over 60 are suddenly asking: Do I still need my thyroid medication? 

You’ll discover why researchers are challenging decades of conventional wisdom, and how a surprising subset of patients may be able to safely reduce—or even stop—treatment under the right conditions.

But here’s where it gets real: this isn’t a story about quitting your meds—it’s about personalization. While about 1 in 4 people in the study successfully stopped their medication, the majority still needed it, and many fell somewhere in between—benefiting from lower doses instead. 

This episode dives into the hidden risks of overtreatment (think heart rhythm issues and bone loss), the gray zone of “borderline” diagnoses, and why aging changes your thyroid needs more than you might expect. It’s nuanced, surprising, and deeply relevant if you’ve ever wondered whether your treatment is still right for you.

Most importantly, this conversation empowers you to rethink “autopilot” healthcare. Deprescribing isn’t about doing less—it’s about doing what’s right, right now. You’ll learn the critical questions to ask your doctor, the signs your body may still depend on thyroid hormone, and why any changes must be slow, strategic, and medically guided. 

🎧 Listen now! Because when it comes to your thyroid, the goal isn’t stopping treatment—it’s getting it exactly right.

LEARN MORE

You can learn more about the topic at the Paloma blog: 

Should Thyroid Medication Be Deprescribed After Age 60?

https://www.palomahealth.com/learn/thyroid-medication-deprescribed-after-age-60-release-trial 

ABOUT PALOMA HEALTH 

⁠⁠Paloma Health ⁠⁠⁠⁠⁠⁠⁠⁠is an online medical practice focused on treating hypothyroidism, Hashimoto’s, perimenopause, menopause, and hormonal weight gain. From online visits with your provider to easy prescription management and lab orders, we create personalized treatment plans for you. 

Become a member⁠, or try our at-home test kit and experience a whole new level of hypothyroid care. Use code PODCAST to save $30 at checkout.

Disclaimer: The $30 discount is only valid for first-time Paloma Health members and test kit users. Coupon must be entered at the time of checkout. 

Become a Paloma Member

https://www.palomahealth.com/pricing-hypothyroidism  

Paloma Complete Thyroid Blood Test Kit

https://www.palomahealth.com/home-thyroid-blood-test-kit

JustLabs - Direct to Consumer Lab Testing

https://justlabs.health/

Your nails might be telling you something your lab tests haven’t caught yet! 

In this episode, we uncover the surprising connection between brittle, peeling, slow-growing nails and hypothyroidism—and why these subtle changes can be an early warning sign of deeper hormonal imbalance. Research shows that low thyroid hormone levels can slow nail growth, reduce blood flow, and weaken the keratin structure that keeps nails strong.

We break down the most common thyroid-related nail symptoms—from splitting and ridges to nail lifting (onycholysis)—and explain why they happen. You’ll learn how thyroid dysfunction disrupts metabolism at the cellular level, affecting everything from nail formation to moisture balance, and why up to a majority of hypothyroid patients experience increased nail fragility.

Most importantly, we talk solutions. From optimizing thyroid treatment to simple lifestyle and nail care strategies, discover what actually works to restore stronger, healthier nails over time. 

 🎧 Learn more about how, sometimes, the smallest clues—like your nails—can reveal the biggest insights about your thyroid health..

LEARN MORE

You can learn more about the topic at the Paloma blog: 

Why Your Nails Break and Peel with Hypothyroidism

https://www.palomahealth.com/learn/nails-break-peel-hypothyroidism 

ABOUT PALOMA HEALTH 

⁠⁠Paloma Health ⁠⁠⁠⁠⁠⁠⁠⁠is an online medical practice focused on treating hypothyroidism, Hashimoto’s, perimenopause, menopause, and hormonal weight gain. From online visits with your provider to easy prescription management and lab orders, we create personalized treatment plans for you. 

Become a member⁠, or try our at-home test kit and experience a whole new level of hypothyroid care. Use code PODCAST to save $30 at checkout.

Disclaimer: The $30 discount is only valid for first-time Paloma Health members and test kit users. Coupon must be entered at the time of checkout. 

BECOME A PALOMA MEMBER

https://www.palomahealth.com/pricing-hypothyroidism  

PALOMA COMPLETE THYROID BLOOD TEST KIT 

https://www.palomahealth.com/home-thyroid-blood-test-kit

JustLabs - DIRECT TO CONSUMER LAB TESTING 

https://justlabs.health/

What if “normal labs” aren’t the same as feeling normal?

In this eye-opening episode, we break down thyroidmaxxing—a smarter, more personalized approach to optimizing hypothyroidism treatment that goes far beyond the standard one-size-fits-all model. Because while medications like levothyroxine are considered the gold standard, many patients still struggle with fatigue, weight gain, and brain fog—even when their labs look “fine.”

We explore what it really means to optimize your thyroid—from dialing in the right medication (T4, T3, or combination therapy) to identifying your optimal lab ranges, not just “in range.”

You’ll also learn how factors like stress, nutrition, metabolism, and even other hormones can make or break how you feel day to day—and why a truly effective treatment plan must be individualized to your body.

If you’ve ever been told “your labs are normal” but still don’t feel like yourself, this episode is your roadmap. 

🎧 Discover how to advocate for better care, uncover hidden barriers to healing, and take control of your thyroid health with a modern, data-driven approach designed to help you feel like you again.

LEARN MORE

You can learn more about the topic at the Paloma blog: 

Thyroidmaxxing: Optimizing Your Thyroid Treatment

https://www.palomahealth.com/learn/thyroidmaxxing-optimizing-hypothyroidism-treatment   

ABOUT PALOMA HEALTH 

⁠⁠Paloma Health ⁠⁠⁠⁠⁠⁠⁠⁠is an online medical practice focused on treating hypothyroidism, Hashimoto’s, perimenopause, menopause, and hormonal weight gain. From online visits with your provider to easy prescription management and lab orders, we create personalized treatment plans for you. 

Become a member⁠, or try our at-home test kit and experience a whole new level of hypothyroid care. Use code PODCAST to save $30 at checkout.

Disclaimer: The $30 discount is only valid for first-time Paloma Health members and test kit users. Coupon must be entered at the time of checkout. 

BECOME A PALOMA MEMBER

https://www.palomahealth.com/pricing-hypothyroidism  

PALOMA COMPLETE THYROID BLOOD TEST KIT 

https://www.palomahealth.com/home-thyroid-blood-test-kit

JustLabs - DIRECT TO CONSUMER LAB TESTING 

https://justlabs.health/

You’ve optimized your labs. Your TSH looks “normal.” And yet… you still feel exhausted, foggy, and off. So what’s going on?

In this episode, we unpack one of the most talked-about—and controversial—concepts in the thyroid world: thyroid pooling.

The theory suggests that your active thyroid hormone, T3, may be “stuck” in your bloodstream instead of getting into your cells where it actually does its job. That could mean you have normal—or even high—T3 levels on paper, but still feel hypothyroid in real life.

But here’s the catch: thyroid pooling is controversial, and there's limited research on it.

So how seriously should you take it? We break down what science does say about T3, cellular uptake, and persistent symptoms—and why a full thyroid evaluation (not just one lab marker) matters most. 

🎧 Learn more about thyroid pooling now!

LEARN MORE

You can learn more about the topic at the Paloma blog: 

What is Thyroid Pooling?

https://www.palomahealth.com/learn/thyroid-pooling 

ABOUT PALOMA HEALTH 

⁠⁠Paloma Health ⁠⁠⁠⁠⁠⁠⁠⁠is an online medical practice focused on treating hypothyroidism, Hashimoto’s, perimenopause, menopause, and hormonal weight gain. From online visits with your provider to easy prescription management and lab orders, we create personalized treatment plans for you. 

Become a member⁠, or try our at-home test kit and experience a whole new level of hypothyroid care. Use code PODCAST to save $30 at checkout.

Disclaimer: The $30 discount is only valid for first-time Paloma Health members and test kit users. Coupon must be entered at the time of checkout. 

Become a Paloma Member

https://www.palomahealth.com/pricing-hypothyroidism  

Paloma Complete Thyroid Blood Test Kit

https://www.palomahealth.com/home-thyroid-blood-test-kit

JustLabs - Direct to Consumer Lab Testing

https://justlabs.health/

Obsessive thoughts. Compulsive behaviors. Anxiety that won’t switch off. What if your thyroid could be playing a bigger role than you think?

In this episode, we explore the surprising connection between OCD and conditions like Hashimoto’s and hypothyroidism—and why mental health symptoms are sometimes rooted deeper in the body than most people realize.

Emerging research shows that people with autoimmune thyroid disorders may have higher rates of OCD, with thyroid hormone imbalances potentially affecting key brain chemicals like serotonin, dopamine, and glutamate.

When these systems are disrupted, it can fuel anxiety, intrusive thoughts, and compulsive patterns—making thyroid health an often-overlooked piece of the puzzle.

If you’ve ever felt like your symptoms don’t fully make sense—or aren’t being taken seriously—this episode connects the dots. 

🎧 Listen now, and find out what’s actually happening in your brain and body, when to consider thyroid testing, and how optimizing your thyroid levels may help improve not just your physical health—but your mental well-being, too.

LEARN MORE

You can learn more about the topic at the Paloma blog: 

OCD, Hashimoto's, and Hypothyroidism

https://www.palomahealth.com/learn/ocd-hashimotos-hypothyroidism 

ABOUT PALOMA HEALTH 

⁠⁠Paloma Health ⁠⁠⁠⁠⁠⁠⁠⁠is an online medical practice focused on treating hypothyroidism, Hashimoto’s, perimenopause, menopause, and hormonal weight gain. From online visits with your provider to easy prescription management and lab orders, we create personalized treatment plans for you. 

Become a member⁠, or try our at-home test kit and experience a whole new level of hypothyroid care. Use code PODCAST to save $30 at checkout.

Disclaimer: The $30 discount is only valid for first-time Paloma Health members and test kit users. Coupon must be entered at the time of checkout. 

Become a Paloma Member

https://www.palomahealth.com/pricing-hypothyroidism  

Paloma Complete Thyroid Blood Test Kit

https://www.palomahealth.com/home-thyroid-blood-test-kit

JustLabs - Direct to Consumer Lab Testing

https://justlabs.health/

Perfume has suddenly become the latest villain on social media—especially for people with Hashimoto’s and hypothyroidism. You may see influencers claiming that spraying fragrance on your neck goes straight to your thyroid.

Can perfume actually harm your thyroid… or is this just another wellness myth gone viral? 

In this episode, we break down what’s real, what’s exaggerated, and what science actually says.

You’ll learn why your thyroid gland is not directly affected by where you spray perfume, and why that fear doesn’t hold up medically. But the conversation doesn’t end there. We dive into the bigger issue: the hidden chemicals inside “fragrance” and how some ingredients—like phthalates and other endocrine disruptors—may influence hormones in more complex, indirect ways.

🎧 If you’ve been feeling overwhelmed by conflicting advice, this episode will help you cut through the noise. Because real thyroid health isn’t about avoiding every scented product—it’s about understanding your total exposure, your symptoms, and what actually moves the needle for your hormones.

LEARN MORE

You can learn more about the topic at the Paloma blog: 

Perfume: What Hashimoto’s and Hypothyroidism Patients Should Know

https://www.palomahealth.com/learn/perfume-hashimotos-hypothyroidism-fragrances 

ABOUT PALOMA HEALTH 

⁠⁠Paloma Health ⁠⁠⁠⁠⁠⁠⁠⁠is an online medical practice focused on treating hypothyroidism, Hashimoto’s, perimenopause, menopause, and hormonal weight gain. From online visits with your provider to easy prescription management and lab orders, we create personalized treatment plans for you. 

Become a member⁠, or try our at-home test kit and experience a whole new level of hypothyroid care. Use code PODCAST to save $30 at checkout.

Disclaimer: The $30 discount is only valid for first-time Paloma Health members and test kit users. Coupon must be entered at the time of checkout. 

Become a Paloma Member

https://www.palomahealth.com/pricing-hypothyroidism  

Paloma Complete Thyroid Blood Test Kit

https://www.palomahealth.com/home-thyroid-blood-test-kit

JustLabs - Direct to Consumer Lab Testing

https://justlabs.health/

Curious about supplements that promise to “fix” your hormones?

In this episode, we take a closer look at DHEA—often called the “anti-aging hormone”—and whether it actually lives up to the hype for people with thyroid conditions. You’ll learn what DHEA does in your body, why levels naturally decline with age, and how it connects to other key hormones like estrogen and testosterone.

But here’s where it gets interesting: while some people with hypothyroidism may have lower DHEA levels—and even share symptoms like fatigue and low libido—the science is still far from clear. We break down what the research really says (and doesn’t say), who might benefit, and the surprising risks you need to know before trying it. 

🎧 Listen now, if you’ve ever wondered whether DHEA could boost your energy, mood, or thyroid function. This Paloma deep dive will help you separate fact from fiction—and make smarter, safer decisions about your health.

LEARN MORE

You can learn more about the topic at the Paloma blog: 

Can DHEA Help With A Thyroid Condition?

https://www.palomahealth.com/learn/dhea-help-thyroid-condition 

ABOUT PALOMA HEALTH 

⁠⁠Paloma Health ⁠⁠⁠⁠⁠⁠⁠⁠is an online medical practice focused on treating hypothyroidism, Hashimoto’s, perimenopause, menopause, and hormonal weight gain. From online visits with your provider to easy prescription management and lab orders, we create personalized treatment plans for you. 

Become a member⁠, or try our at-home test kit and experience a whole new level of hypothyroid care. Use code PODCAST to save $30 at checkout.

Disclaimer: The $30 discount is only valid for first-time Paloma Health members and test kit users. Coupon must be entered at the time of checkout. 

Become a Paloma Member

https://www.palomahealth.com/pricing-hypothyroidism  

Paloma Complete Thyroid Blood Test Kit

https://www.palomahealth.com/home-thyroid-blood-test-kit

JustLabs - Direct to Consumer Lab Testing

https://justlabs.health/

Have you ever been told your thyroid tests are “perfectly normal” — yet you still feel exhausted, foggy, cold, and unlike yourself? In this episode, we explore a frustrating and widely misunderstood condition called euthyroid Hashimoto’s.

It happens when people with Hashimoto’s thyroiditis continue to experience debilitating symptoms even though their TSH and other standard thyroid labs fall within the normal range. New research is beginning to explain why this disconnect happens — and why so many patients feel dismissed when their test results don’t match how they actually feel.

We dive into the emerging science showing that Hashimoto’s isn’t just a thyroid problem — it’s a systemic autoimmune disease. Even when hormone levels look normal, the immune system may still be actively attacking the thyroid, releasing inflammatory molecules that affect the brain, metabolism, and mood. That inflammation can drive symptoms like profound fatigue, brain fog, depression, cold intolerance, and weight gain — problems that standard thyroid testing often misses.

Finally, we discuss what this new understanding means for patients and clinicians. From testing beyond TSH to addressing inflammation, nutrient deficiencies, and lifestyle factors, a more comprehensive approach to thyroid care is starting to take shape. 

🎧 If you’ve ever wondered why your labs look “fine” but you still feel terrible, this episode will help you understand what may really be going on — and what steps could help you start feeling like yourself again. 

LEARN MORE

You can learn more about the topic at the Paloma blog: 

What is Euthyroid Hashimoto’s? When You Have Symptoms with Normal Thyroid Tests

www.palomahealth.com/learn/euthyroid-hashimotos-symptoms-with-normal-thyroid-tests 

ABOUT PALOMA HEALTH 

⁠⁠Paloma Health ⁠⁠⁠⁠⁠⁠⁠⁠is an online medical practice focused on treating hypothyroidism, Hashimoto’s, perimenopause, menopause, and hormonal weight gain. From online visits with your provider to easy prescription management and lab orders, we create personalized treatment plans for you. 

Become a member⁠, or try our at-home test kit and experience a whole new level of hypothyroid care. Use code PODCAST to save $30 at checkout.

Disclaimer: The $30 discount is only valid for first-time Paloma Health members and test kit users. Coupon must be entered at the time of checkout. 

Become a Paloma Member

https://www.palomahealth.com/pricing-hypothyroidism  

Paloma Complete Thyroid Blood Test Kit

https://www.palomahealth.com/home-thyroid-blood-test-kit

JustLabs - Direct to Consumer Lab Testing

https://justlabs.health/

The world of thyroid treatment has been turned upside down—and if you rely on natural desiccated thyroid (NDT), this episode is one you can’t afford to miss! After a shocking 2025 crackdown that threatened to pull NDT medications off the market entirely, the FDA has just made a dramatic shift in March 2026! 

____________________________________________________

What does this sudden reversal really mean—and why are patients and doctors still on edge?____________________________________________________In this episode, we break down the real story behind the headlines: how the FDA quietly removed its hard 2026 enforcement deadline, pivoted to a “risk-based” approach, and signaled that NDT medications can remain available—for now. But there’s a catch. These treatments are still technically unapproved, and new pressures—especially from insurers—may make access more difficult even as regulation eases.

If you’ve ever felt caught between what works for your body and what the system allows, this conversation will hit home. 

🎧 Listen now, and explore what this policy shift means for your treatment options, your wallet, and your future—and why the fight over thyroid care is far from over.

LEARN MORE

You can learn more about the topic at the Paloma blog: 

Natural Desiccated Thyroid (NDT): FDA Signals Policy Shift in March 2026 Guidance

https://www.palomahealth.com/learn/natural-desiccated-thyroid-ndt-fda-policy-shift-march-2026 

ABOUT PALOMA HEALTH 

⁠⁠Paloma Health ⁠⁠⁠⁠⁠⁠⁠⁠is an online medical practice focused on treating hypothyroidism, Hashimoto’s, perimenopause, menopause, and hormonal weight gain. From online visits with your provider to easy prescription management and lab orders, we create personalized treatment plans for you. 

Become a member⁠, or try our at-home test kit and experience a whole new level of hypothyroid care. Use code PODCAST to save $30 at checkout.

Disclaimer: The $30 discount is only valid for first-time Paloma Health members and test kit users. Coupon must be entered at the time of checkout. 

Become a Paloma Member

https://www.palomahealth.com/pricing-hypothyroidism  

Paloma Complete Thyroid Blood Test Kit

https://www.palomahealth.com/home-thyroid-blood-test-kit

JustLabs - Direct to Consumer Lab Testing

https://justlabs.health/

If you're a new mom drowning in exhaustion, anxiety, or a fog you can't shake — and everyone keeps telling you it's "just the baby blues" — this episode is for you!

We're unpacking postpartum depression in a way most providers never do: going beyond the emotional symptoms to reveal a hidden biological driver that affects up to 1 in 7 new parents. Spoiler: your thyroid might be playing a much bigger role in how you feel than anyone has told you.

In this episode, we dive into the surprising connection between thyroid dysfunction — including postpartum thyroiditis and Hashimoto's disease — and postpartum depression. Fatigue, brain fog, low mood, weight changes, hair loss: these aren't just signs of "new mom life." For many women, these are thyroid symptoms being mistaken for depression, or quietly making depression worse.

We break down the research showing that women with autoimmune thyroid conditions are significantly more likely to experience postpartum depressive symptoms — and why so many cases go undiagnosed and undertreated.

We also cover what's new in treatment — including the buzzed-about "two-week pill" zuranolone, the first FDA-approved oral medication specifically for postpartum depression, and why so few women are actually getting access to it.

🎧 Listen in, and you’ll walk away knowing exactly what to ask your doctor, which tests to request, and how a whole-body approach — addressing both your mental health and your thyroid — could be the missing piece in your recovery. Because you deserve answers, not just reassurance.

LEARN MORE

You can learn more about the topic at the Paloma blog: 

Postpartum Depression and Your Thyroid: The Hidden Connection

https://www.palomahealth.com/learn/postpartum-depression-thyroid-hidden-connection 

ABOUT PALOMA HEALTH 

⁠⁠Paloma Health ⁠⁠⁠⁠⁠⁠⁠⁠is an online medical practice focused on treating hypothyroidism, Hashimoto’s, perimenopause, menopause, and hormonal weight gain. From online visits with your provider to easy prescription management and lab orders, we create personalized treatment plans for you. 

Become a member⁠, or try our at-home test kit and experience a whole new level of hypothyroid care. Use code PODCAST to save $30 at checkout.

Disclaimer: The $30 discount is only valid for first-time Paloma Health members and test kit users. Coupon must be entered at the time of checkout. 

Become a Paloma Member

https://www.palomahealth.com/pricing-hypothyroidism  

Paloma Complete Thyroid Blood Test Kit

https://www.palomahealth.com/home-thyroid-blood-test-kit

JustLabs - Direct to Consumer Lab Testing

https://justlabs.health/