Hims House

Ep 33 - Max Marchione: Superpower, Hims, and the future of AI-powered medicine


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In episode 33 of Hims House, hosts Jonathan Stern and Patrick Lester sit down with Max Marchione, founder of Superpower — a health tech startup reimagining preventive care through AI, advanced diagnostics, and personalized protocols. The conversation explores how healthcare might look if rebuilt from first principles today, why AI could become the true "front door" to care, and how Superpower is betting on a tech-first model. Max also shares candid thoughts on Hims' billion-dollar raise, its AI and international strategy, the potential of peptides, and what it takes to build a healthcare brand with cultural pull.

00:00 – The Godel Terminal

01:01 – Intro - Max Marchione & Superpower’s Mission

02:40 – Reimagining Healthcare from First Principles

04:16 – AI as the New Front Door to Care

07:18 – Lessons Learned: Superpower’s Evolving Strategy

17:24 – Branding in Healthcare: Sci-Fi vs. Friendly

23:29 – Long-Term Vision: Membership, Outcomes, and Impact

28:01 – Vertical Integration & Personalized Therapeutics

30:14 – Hims, AI, and the Commoditization of Care

32:52 – Global Expansion: Who Hims Might Acquire

38:48 – What Peptides Are and Why They Matter

42:45 – Legal Gray Zones

46:43 – Innovation in the UAE & Saudi Arabia

50:11 – Taking More Risks

52:43 – Final Reflections



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Hims HouseBy Jonathan Stern

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