Is minimally invasive ablation the future of metastatic cancer care? We now have the results of the COLLISION Trial, which investigates the non-inferiority of thermal ablation compared to surgical resection. How will these findings change treatment paradigms and practice patterns around metastatic colorectal cancer? In this week’s episode of BackTable, interventional radiologist Dr. Chris Beck discusses the impact and implications of the COLLISION Trial with principal investigator Dr. Martijn Meijerink from Amsterdam UMC.
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SYNPOSIS
The doctors explore the COLLISION Trial’s design, results, complication rates, and future directions. They also cover best practices for ablation techniques and the potential for interventional oncology to enter a “golden era.” Finally, Dr. Meijerink highlights the importance of standardizing intervention quality and being present in tumor boards to ensure optimal patient care.
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TIMESTAMPS
00:00 - Introduction
03:21 - Understanding Metastatic Colorectal Cancer and IR’s Role
05:18 - Introduction to the COLLISION Trial
07:40 - Radiofrequency vs Microwave Ablation and Technological Advancements
09:02 - Trial Design and Patient Eligibility
16:20 - Ablation Techniques and Approaches
22:05 - Trial Results and Analysis
30:19 - Impact on Guidelines and Practice
39:44 - Best Practices in Thermal Ablation
43:27 - Future Directions in Interventional Oncology
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RESOURCES
“Surgery versus thermal ablation for small-size colorectal liver metastases (COLLISION): An international, multicenter, phase III randomized controlled trial.” (Meijerink, 2024)
https://ascopubs.org/doi/10.1200/JCO.2024.42.17_suppl.LBA3501