Dr. Alessandro Sette is a Center Head, Division Head, and Professor at the La Jolla Institute of Allergy and Immunology. His lab focuses on understanding the immune response, measuring immune activity, and developing disease intervention strategies against cancer, autoimmunity, allergy, and infectious diseases. He talks about bringing a biotech mindset back to academia, cross-reactive T cell responses to SARS-CoV-2, and compiling an immune-epitope database.

Gut T Cells and Cancer Metastasis – A subset of CD8+ T cells from colon tumors improves control of liver tumors in a preclinical model of colorectal carcinoma.

α2-adrenergic Receptors and Immunotherapy – α2-Adrenergic receptor agonists have very strong anti-tumor activity when used as monotherapies in multiple immunocompetent tumor models.

Bacteria in Immune Checkpoint Blockade – Antibiotic-induced changes in gut microbiota resulted in relocation of immunosuppressive T cells from the gut to tumors.

Base Editing CAR T Cells – Researchers investigated the safety of base-edited CAR T cells in three children with relapsed leukemia.

Image courtesy of Dr. Alessandro Sette

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