Dr. Jeffrey Rathmell is the Cornelius Vanderbilt Professor of Immunobiology at the Vanderbilt Center for Immunobiology. His research focuses on T cell metabolism in cancer. He talks about what T cells use for fuel and his work on fatty acid synthesis. He also discusses the ‘obesity paradox’ in cancer immunotherapy and his favorite parts of being a scientist and professor.

A Humanized Mouse Model – A new humanized mouse mounts specific and mature antibody and autoantibody responses.

IL-11 Signaling in Aging – Inhibiting IL-11 extends the healthspan and lifespan of mice.

Sphinganine Synthesis in Macrophages – Sphinganine biosynthesis is a checkpoint for macrophage pattern recognition in mouse models of sepsis and melanoma.

Brain-Muscle Signaling – Researchers identified a brain-to-muscle signaling axis in Drosophila that regulates muscle performance.

Image courtesy of Dr. Jeffrey Rathmell

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