這次的專題系列來跟大家講講糖跟代糖的差別，喝零卡可樂為什麼喝完好像嘴巴會怪怪的？代糖跟糖又該怎麼選擇？或是代糖是怎麼做到零熱量的呢？這些解答都在這次的科學十分鐘專題系列！

內容延伸代謝途徑 （簡化很多大概讓大家知道一下）：
Carbohydrate metabolism:

• In the liver -> 20% glucose hit the liver cell -> Insulin -> IRS-1 -> SREBP1 -> Glucokinase takes glucose -> G6P -> Glycogen G6P -> Pyruvate -> TCA cycle -> ATP Co2 -> citrate ->De novo lipogenesis (making fat process) -> FAT -> VLDL -> heart disease 

Sugar (glucose and fructose) metabolism:

• 100% hit the liver cell -> pyruvate -> TCA cycle mitochondria -> citrate -> VLDL -> free fatty acid -> insulin resistance -> non-alcholic fatty acid liver -> JNK -> inflammation -> IRS-1 insulin 

Sources:
Explained Season 3: Sugar
Matt D’Avella -> I quit sugar for 30 days 
Why Sugar is as bad as alcohol -> (what I’ve learned)
https://www.healthline.com/nutrition/artificial-sweeteners-good-or-bad#how-they-work
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014832/
https://www.mayoclinic.org/diseases-conditions/diabetes/expert-answers/artificial-sweeteners/faq-20058038

https://www.embopress.org/doi/full/10.15252/emmm.201911668
https://blogs.cornell.edu/daytodayeats/2019/11/01/natural-sugars-vs-artificial-sweeteners/
https://www.uofmhealth.org/health-library/abj7112

Paper for Pdia4:
https://pubmed.ncbi.nlm.nih.gov/34542937/

#podcast #science #科學 #科普分享 #知識 #糖 #代糖 #零卡可樂 #健身 #營養 #糖尿病 #中風 #飲食 #大腦 #飲食習慣 #心臟病 #代謝問題 #科學十分鐘 

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