WolverHeme Happy Hour

Episode 3.1: History of Acute Lymphoblastic Leukemia Treatment and Building the BFM Backbone

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In part one of a two-part episode, Bernie Marini and Anthony Perissinotti take a journey through the history of acute lymphoblastic leukemia treatment throughout the decades and explain how we got to our current standard of care treatment of ALL patients. In part 2 we tackle the UKALL14 study evaluating the addition of rituximab to acute lymphoblastic leukemia therapy.

Some important historical articles that we reference:

  • Nitrogen mustard therapy: https://pubmed.ncbi.nlm.nih.gov/20997191/
  • Methotrexate/Aminopterin: https://www.nejm.org/doi/full/10.1056/nejm194806032382301
    • Vincristine: https://pubmed.ncbi.nlm.nih.gov/13627916/ and https://pubmed.ncbi.nlm.nih.gov/2085431/ and https://www.utpjournals.press/doi/pdf/10.3138/cbmh.17.1.155
    • 6-MP: https://pubmed.ncbi.nlm.nih.gov/13105700/
    • Total Therapy: https://pubmed.ncbi.nlm.nih.gov/5237796/ and https://pubmed.ncbi.nlm.nih.gov/5279904/
    • BFM: https://pubmed.ncbi.nlm.nih.gov/320377/ and https://pubmed.ncbi.nlm.nih.gov/23700050/

      • This episode is dedicated to the late Don Pinkel (9/7/1927 - 3/9/2022), a pioneer in the treatment of childhood ALL. Read more about his legacy here: https://cancerletter.com/obituary/20220318_4/ and https://www.nature.com/articles/s41375-022-01562-9.pdf and https://www.smithsonianmag.com/innovation/childhood-leukemia-untreatable-dr-don-pinkel-st-jude-180959501/

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      WolverHeme Happy HourBy Bernard Marini, Anthony Perissinotti, et al.
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