WolverHeme Happy Hour

Episode 3.1: History of Acute Lymphoblastic Leukemia Treatment and Building the BFM Backbone

Listen Later

In part one of a two-part episode, Bernie Marini and Anthony Perissinotti take a journey through the history of acute lymphoblastic leukemia treatment throughout the decades and explain how we got to our current standard of care treatment of ALL patients. In part 2 we tackle the UKALL14 study evaluating the addition of rituximab to acute lymphoblastic leukemia therapy.

Some important historical articles that we reference:

  • Nitrogen mustard therapy: https://pubmed.ncbi.nlm.nih.gov/20997191/
  • Methotrexate/Aminopterin: https://www.nejm.org/doi/full/10.1056/nejm194806032382301
    • Vincristine: https://pubmed.ncbi.nlm.nih.gov/13627916/ and https://pubmed.ncbi.nlm.nih.gov/2085431/ and https://www.utpjournals.press/doi/pdf/10.3138/cbmh.17.1.155
    • 6-MP: https://pubmed.ncbi.nlm.nih.gov/13105700/
    • Total Therapy: https://pubmed.ncbi.nlm.nih.gov/5237796/ and https://pubmed.ncbi.nlm.nih.gov/5279904/
    • BFM: https://pubmed.ncbi.nlm.nih.gov/320377/ and https://pubmed.ncbi.nlm.nih.gov/23700050/

      • This episode is dedicated to the late Don Pinkel (9/7/1927 - 3/9/2022), a pioneer in the treatment of childhood ALL. Read more about his legacy here: https://cancerletter.com/obituary/20220318_4/ and https://www.nature.com/articles/s41375-022-01562-9.pdf and https://www.smithsonianmag.com/innovation/childhood-leukemia-untreatable-dr-don-pinkel-st-jude-180959501/

      ...more
      View all episodesView all episodes
      Download on the App Store
      WolverHeme Happy HourBy Bernard Marini, Anthony Perissinotti, et al.
      • 4.5
      • 4.5
      • 4.5
      • 4.5
      • 4.5

      4.5

      28 ratings

      More shows like WolverHeme Happy Hour

      View all
      The Hematologist by The Hematologist

      The Hematologist

      26 Listeners

      JAMA Clinical Reviews by JAMA Network

      JAMA Clinical Reviews

      496 Listeners

      OncoPharm by John Bossaer

      OncoPharm

      185 Listeners

      VJHemOnc Podcast by VJHemOnc

      VJHemOnc Podcast

      3 Listeners

      The Peter Attia Drive by Peter Attia, MD

      The Peter Attia Drive

      7,953 Listeners

      Plenary Session - inactive due to federal service by Vinay Prasad, MD MPH

      Plenary Session - inactive due to federal service

      755 Listeners

      Treating Blood Cancers by The Leukemia & Lymphoma Society

      Treating Blood Cancers

      12 Listeners

      Blood Podcast by American Society of Hematology

      Blood Podcast

      51 Listeners

      Oncology Today with Dr Neil Love by Dr. Neil Love

      Oncology Today with Dr Neil Love

      56 Listeners

      Healthcare Unfiltered by Chadi Nabhan

      Healthcare Unfiltered

      134 Listeners

      EHA Unplugged by European Hematology Association

      EHA Unplugged

      1 Listeners

      Two Onc Docs by Sam and Karine

      Two Onc Docs

      169 Listeners

      Blood Cancer Talks by Rajshekhar Chakraborty, Ashwin Kishtagari, and Edward Cliff

      Blood Cancer Talks

      48 Listeners

      Oncology Brothers: Practice-Changing Cancer Discussions by Oncology Brothers

      Oncology Brothers: Practice-Changing Cancer Discussions

      39 Listeners

      HemeTalks: Conversations in Hematology Education by American Society of Hematology

      HemeTalks: Conversations in Hematology Education

      3 Listeners