Adrenal insufficiency is a life-threatening condition but diagnosis is typically delayed. The initial presentation is often non-specific and physician awareness must be improved to avoid adrenal crisis. Join endocrine experts Shobana Athimulam, MD, Clinical Assistant Professor, Division of Endocrinology, Bone and Mineral Disorders in Henry Ford Health, Detroit, Michigan, and Lucinda Gruber, MD, Assistant Professor, Division of Endocrinology, Diabetes, Metabolism and Nutrition at Mayo Clinic in Rochester, Minnesota, as they discuss the etiology and clinical presentation of patients with adrenal insufficiency, challenges in making the diagnosis, role of dynamic testing and management of special patient populations.