In this episode of Going anti-Viral, Dr Michael Saag speaks with Dr Andy Pavia of the University of Utah for an update on COVID-19. Dr Pavia and Dr Saag review COVID-19 cases and deaths in 2024 including a discussion about the reasons why deaths have declined compared with earlier years in the pandemic. They also review Long COVID and challenges clinicians face with treatment. Dr Pavia provides a detailed review of COVID-19 vaccines and effectiveness including recommendations on who should be vaccinated. Dr Saag and Dr Pavia review COVID-19 testing, including home testing and antiviral (including monoclonal antibody) treatments. They also discuss how best to provide early treatment to persons at high risk of developing severe disease. Finally, they provide predictions for the future including possible improvements in next generation of COVID-19 vaccines.

0:00 – Introduction

1:21 – COVID-19 cases and deaths in 2024

3:21 – Discussion of reduction in deaths 

5:11 – Evolution of COVID-19 immunity and discussion of Long COVID

12:37 – Challenges in treating Long COVID

16:20 – Review of data on effectiveness of COVID-19 vaccines and current recommendations on who should receive a vaccine

19:10 – Recommendations on use of antiviral treatments and testing – including recommendations for persons at high risk for developing severe disease

23:16 – Discussion of use of remdesivir

24:44 – Recommendations for use of pemivibart in persons who are immune compromised 

26:30 – Predictions for future therapies and vaccines 

28:11 – Summary and closing remarks 

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Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.

Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences.

Email [email protected] to send feedback, show suggestions, or questions to be answered on a later episode.

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