On this episode of JHLT: The Podcast, the Digital Media Editors invite first author Gaurav Sharma, PhD, MBA, from the University of Texas Southwestern Medical Center in Dallas. Dr. Sharma discusses his paper, “Metabolic and transcriptomic insights into temperature controlled hypothermic preservation of human donor hearts.”

The discussion explores:

• How donor hearts not offered or declined for transplantation responded in hypothermic preservation versus conventional static cold storage
• Potentially beneficial genetic signatures yielded by TCHP versus cold storage
• The surprising response of energy stores in the hearts to the different storage environments
• How multi-omic approaches could be applied to other organs

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