On this episode of JHLT: The Podcast, the Digital Media Editors host a discussion on the paper, "Impact of donor specific antibodies on longitudinal lung function and baseline lung allograft dysfunction."

They are joined by the first author, Muhtadi Alnababteh, MD, Assistant Professor at the University of Maryland and Staff Clinician at the National Institutes of Health, and senior author Michael Keller, MD, of the Pulmonary and Critical Care division at the University of Maryland.

The discussion explores:

• Common characteristics of patients who developed donor-specific antibodies (DSA)
• Differences in outcomes depending on when DSA developed
• Associations between the development of DSA and antibody-mediated rejection, and related time frames

For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.

Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

On this episode of JHLT: The Podcast, the Digital Media Editors invite co-lead author Nir Uriel, MD, Director of Advanced Heart Failure and Cardiac Transplantation at New York Presbyterian Hospital and Professor of Medicine at Columbia University.

Dr. Uriel joins to discuss the work of the Cardiogenic Shock Working Group (CSWG) and their recent paper, "Outcomes of patients supported on Impella 5.5 for more than 14 days: A Cardiogenic Shock Working Group registry analysis."

The discussion explores:

• Why patients on longer duration of MCS had better survival but maintained similar rates of serious adverse events (SAEs)
• Why the study might show fewer SAEs than the literature historically shows
• How temporary MCS devices are selected in clinical settings in patients with cardiogenic shock
• The ongoing and upcoming activities of CSWG

For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.

Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

On this episode of JHLT: The Podcast, the Digital Media Editors invite author Dr. Ayumi Goda, from the Kyorin University Hospital in Tokyo, Japan, to discuss her team's paper, "Prevalence of occult HFpEF and age-specific efficacy of passive leg raise in pulmonary hypertension."

The discussion explores:

• How clinical observations led to the idea for a study on whether the passive leg raise could unmask occult HFpEF
• The potential diagnostic value of the passive leg raise in differing patient populations
• Age-specific cutoffs that may influence what kind of testing to use in clinical practice

For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.

Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

On this episode of JHLT: The Podcast, the Digital Media Editors invite first author Ahmet Bilgili, from the University of Florida's Congenital Heart Center, and senior author Eric I. Jeng, MD, from the University of Florida's MCS program.

Bilgili and Dr. Jeng discuss their paper, "Optimal pretransplant duration with HeartMate III left ventricular assist device: A contemporary analysis."

The discussion explores:

• Prior gaps in the literature regarding contemporary HM3 outcomes in relation to transplantation—and the study's potential influence on policy
• Which length of HM3 support influenced better post-transplant outcomes—and which ages were most influenced
• How these findings might change standard practice

For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.

Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

On this episode of JHLT: The Podcast, the Digital Media Editors invite first author Luke Williams, a cardiothoracic surgery trainee at Royal Papworth Hospital, NHS Blood and Transplant Clinical Research Fellow, and a PhD student at Cambridge University in the UK. Luke discusses his paper, "The United Kingdom's experience of controlled donation after circulatory death direct procurement of lungs with concomitant abdominal normothermic regional perfusion with an analysis of short-term outcomes."

The discussion explores:

• Requirements, regulations, and practices in the UK around DCD procurement and A-NRP
• How survival rates differ and what they might imply about primary graft dysfunction in DCD versus DBD
• Further work planned in the area in the UK and throughout Europe

For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.

Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

On this episode of JHLT: The Podcast, the Digital Media Editors invite first author Gaurav Sharma, PhD, MBA, from the University of Texas Southwestern Medical Center in Dallas. Dr. Sharma discusses his paper, "Metabolic and transcriptomic insights into temperature controlled hypothermic preservation of human donor hearts."

The discussion explores:

• How donor hearts not offered or declined for transplantation responded in hypothermic preservation versus conventional static cold storage
• Potentially beneficial genetic signatures yielded by TCHP versus cold storage
• The surprising response of energy stores in the hearts to the different storage environments
• How multi-omic approaches could be applied to other organs

For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.

Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

On this episode of JHLT: The Podcast, the Digital Media Editors invite first author Joan Guzmán-Bofarull, and senior author, Marta Farrero, both of the Hospital Clinic de Barcelona in Spain. They join to discuss their paper, "Regional differences in primary graft dysfunction: A report from the international consortium on PGD."

The discussion explores:

• The international consortium on PGD, the composition of the study, and the practices of the included countries in the United States, Canada, and Europe
• Hypotheses on why the study shows better 30-day and 1-year outcomes in the United States
• Considerations transplant centers can take regarding recipient management and donor heart selection

For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.

Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

On this episode of JHLT: The Podcast, the Digital Media Editors invite first author Nikil Prasad, MD, a cardiology fellow in the Columbia University Medical Center in New York, to discuss the paper, "Can the grading of mild cardiac allograft vasculopathy be further refined? An angiographic and physiologic assessment of heart transplant recipients with ISHLT CAV 1."

The discussion explores:

• The study's subdivisions of CAV grade 1 into CAV 1a and CAV 1b, based on the degree of coronary stenosis
• Differing clinical information provided by different methods of CAV screening: reduced myocardial blood flow reserve vs angiographic grading
• Limitations in implementing PET-based CAV assessments at various centers, and how transplant programs can use combined testing data

For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.

Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

On this special episode of JHLT: The Podcast, the Digital Media Editors take a look back at the exciting science that was on display at ISHLT2025, the ISHLT 45th Annual Meeting & Scientific Sessions.

Topics include:

• Telomere biology disorders and lung transplantation
• The meeting's special focus on cardiogenic shock
• The apixiVAD trial exploring low dose apixaban in HeartMate 3 LVADs
• Myocardial recovery on durable LVADs

For the latest studies from JHLT, visit jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at ishlt.org/jhlt. Full-text abstracts of the meeting can also be found at the JHLT website.

Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

On this episode of JHLT: The Podcast, the Digital Media Editors invite first author Peter Cho and senior author Abbas Ardehali, MD, to discuss the paper, "Severe primary graft dysfunction in heart transplant recipients using donor hearts after circulatory death: a United States Experience."

Peter is a third year medical student at Drexel University, and Dr. Ardehali is professor of surgery and medicine and the Director of the Heart, Lung, and Heart-Lung Transplant programs at UCLA.

The episode explores:

• The study's findings regarding an increased incidence of severe PGD at 24 hours post-transplant in DCD over DBD recipients
• What risks weren't changed in DCD recipients—suggesting that DCD PGD is likely to be transient, and may have a different phenotype
• How NRP may impact the outcomes
• Mitigating the risk of PGD

For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.

Tune in again later this month for the Digital Media Editors' findings and observations from the ISHLT2025 Annual Meeting in Boston.

Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.