Cast:

Joel Topf

Jennie Lin

Samira Farouk

Swapnil Hiremath

Show Notes:

NephJC coverage of SONAR: http://www.nephjc.com/news/sonar

SONAR in PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30995972

Avosentan for overt diabetic nephropathy, the ASCEND trial: https://www.ncbi.nlm.nih.gov/pubmed/20167702

RADAR coverage at NephJC, May 2014: http://www.nephjc.com/atrasentan

RADAR in PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24722445/

Google Hangout on RADAR: https://www.youtube.com/watch?v=pkkQbb-isog&feature=youtu.be

Vlado Perkovic: https://twitter.com/VladoPerkovic

SONAR: https://en.wikipedia.org/wiki/Sonar

Nephmadness adaptive trial: https://ajkdblog.org/2016/03/10/nephmadness-2016-statistics-in-nephrology-region/#adaptive

KIDNEYcon adaptive trial tweet thread: https://twitter.com/hswapnil/status/1117194018331471873?s=21

Excellent NEJM review on adaptive trials: https://www.nejm.org/doi/10.1056/NEJMra1510061

Potential role of Adaptive trials in AKI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869991/

BNP levels in CKD: https://cjasn.asnjournals.org/content/3/6/1644

Generalizability from Wikipedia: https://en.wikipedia.org/wiki/Generalizability_theory

Anemia (and other adverse effects) of Endothelin antagonists: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210319/

Data safety monitoring boards: https://www.nidcr.nih.gov/research/human-subjects-research/interventional-studies/data-and-safety-monitoring-board-guidelines

AbbVie Allergen Merger: https://www.barrons.com/articles/abbvie-allergan-merger-pharma-deals-takeda-celgene-bristol-myers-squibb-51563890831

Tangri Kidney Failure Risk Equation: https://qxmd.com/calculate/calculator_308/kidney-failure-risk-equation-4-variable

Fragility index paper: https://www.ncbi.nlm.nih.gov/m/pubmed/24508144/

LITFL write up: https://litfl.com/fragility-index/

Calculator: https://clincalc.com/Stats/FragilityIndex.aspx

CANVAS Trial: https://www.nejm.org/doi/full/10.1056/NEJMoa1811744

Rates of Hyperkalemia after Publication of the Randomized Aldactone Evaluation Study by David Juurlink et al.: https://www.nejm.org/doi/full/10.1056/NEJMoa040135

Vinay Prasad: https://en.wikipedia.org/wiki/Vinay_Prasad

Classic mouse studies looking at endothelin: https://www.jci.org/articles/view/119297/pdf
https://www.ncbi.nlm.nih.gov/pubmed/8377387/
https://diabetes.diabetesjournals.org/content/65/8/2429

Nice reviews:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698004/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216619/

Review of vascular effects:
https://www.ncbi.nlm.nih.gov/pubmed/28223322