The Filtrate:

Joel Topf

Swapnil Hiremath

Samira Farouk

And special guests:

Katalin Susztak, Professor of Medicine Perlman School of Medicine, University of Pennsylvania. @KSusztak

Show Notes:

CKD-FIX: Effects of Allopurinol on the Progression of Chronic Kidney Disease

PERL: Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes

Coverage at NephJC: Effects of Allopurinol on the Progression of Chronic Kidney Disease

Richard Johnson’s theory in pay-walled Nature Reviews Nephrology: Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome

Richard Johnson’s theory in open access Nehrology Dialysis and Transplantation: Uric acid and chronic kidney disease: which is chasing which?

PERL: Preventing early renal loss

Iohexol, good for measuring GFR as well as causing contrast associated nephropathy?

Uric acid versus urate: The Crystallization of Monosodium Urate

Association of HLA-B*5801 allele and allopurinol-induced Stevens Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis

WHO list of essential medications

Fixing the numbers, specifically phosphorous

GFR Decline as an End Point for Clinical Trials in CKD: A Scientific Workshop Sponsored by the National Kidney Foundation and the US Food and Drug Administration

Cost of allopurinol: $7/month but it is only $9 for 3 months

Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial

Tipping point analysis - multiple imputation for stress test under missing not at random (MNAR) or a YouTube video if that’s your speed (sorry, I couldn’t find a TikTok on imputation stress tests).

Mendelian randomization study of urate and CKD by Ron Do and team

Dad jokes

Fake systematic review by Johnson’s group showing Urate lowering prevented CKD

Hyperuricemia As a trigger of Immune Response in Hypertension and Chronic Kidney Disease by Claudio Ponticelli published the week after these two RCTs were published.

NEJM Editorial: Urate-Lowering Therapy and Chronic Kidney Disease Progression by Daniel Feig

COVID and PPI manuscript

Hashtag the cowboy

‘WhatsApp®’ening in nephrology training

Arkana LIVE Pathology Sessions

NephJC Summer Book Club. Read Rana Awdish’s In Shock