The Filtrate:

Joel Topf

Swapnil Hiremath

Jordy Cohen

With Special Guest:

Laurie Tomlinson. @Roxytonin Nephrologist at University Hospitals Sussex and research hero of Jordy.

Editor:

Priya Yenebere

Show Notes:

STOP-ACE in pubmed: Renin-Angiotensin System Inhibition in Advanced Chronic Kidney Disease

STOP-ACE Summary in NephJC

Prior data showing preservation of renal function by stopping ACEi: The impact of stopping inhibitors of the renin-angiotensin system in patients with advanced chronic kidney disease

Efficacy and Safety of Benazepril for Advanced Chronic Renal Insufficiency: NEJM

Dr. Tomlinson’s article on creatinine changes in RASi from 2017: Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study NephJC | PubMed

Accuracy of eGFR at low GFR: A new equation to estimate glomerular filtration rate

Strong opinions, loosely held.

“Permissive AKI” with treatment of heart failure. Editorial by Chirag Parish and Steven Coca

The rational for NICE avoiding RASi in black patients: Hypertension and ethnic group

AASK trial showing superiority of RASi in African Americans. JAMA

ALLHAT post-hoc analysis of outcomes by self-reported race. JAMA | PubMed

Sophisticated Swedish observational study that Swap loved. Stopping Renin-Angiotensin System Inhibitors in Patients with Advanced CKD and Risk of Adverse Outcomes: A Nationwide Study

Target Trials in Nephrology Dr Edouard Fu grand rounds at Ottawa Nephrology, YouTube

Target Trial EmulationA Framework for Causal Inference From Observational Data by Miguel Hernán in JAMA

Tubular Secretions

Jordy: Third season of His Dark Materials on HBO

Swap: Movies by Wes Anderson on Disney Plus

Laurie: The Book, “Nearly All the Men in Lagos are Mad”

Jordy: How Medicine Works and When It Doesn't: Learning Who to Trust to Get and Stay Healthy | Amazon

Joel EO | NYT Review