In episode 78 of Going anti-Viral, Dr Rajesh T. Gandhi joins host Dr Michael Saag to discuss the process of guidelines development. Dr Gandhi is a Professor of Medicine at Harvard Medical School and Principal Investigator and Co-Director of the Harvard University Center for AIDS Research (CFAR). Dr Gandhi is the Vice-Chair of the ACTG, Vice-Chair of the Infectious Diseases Society of America COVID-19 Treatment Guidelines Panel, Chair of the International Antiviral Society-USA Panel on Antiretroviral Drugs for Treatment and Prevention of HIV in Adults, and the Lead Editor for Infectious Diseases, NEJM Clinician. Dr Gandhi and Dr Saag explore the intricate process of developing HIV treatment guidelines, including evidence review, panel selection, and updates on new topics like transgender care and substance use disorders. They discuss how guidelines are created, their impact on clinical practice, and future directions in HIV care.

0:00 – Introduction 

1:54 – The purpose and impact of guidelines

4:00 – Panel composition and selection process

6:00 – Guideline structure and key updates

12:34 – Emerging topics: transgender care and transplant medicine

14:31 – Substance use disorders and treatment innovations

16:03 – Evidence-based recommendations and their strength

22:07 – Guidelines development process and team dynamics

24:42 – Living guidelines versus published documents

28:41 – Closing thoughts and future directions

Resources: 

Going-anti-Viral: Episode 32 - Update on the New Antiretroviral Therapy Guidelines - Dr Rajesh Gandhi

YouTube:  https://youtu.be/G7FQTInz-dY 

Apple Podcasts:  https://podcasts.apple.com/us/podcast/episode-32-update-on-the-new-antiretroviral-therapy/id1713226144?i=1000678818027 

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Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.

Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences.

Email [email protected] to send feedback, show suggestions, or questions to be answered on a later episode.

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