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General Hospital spoilers for Sept 29 - Oct 03, 2025 expect some thrilling twists and turns. Drew Cain Quartermaine (Cameron Mathison) takes a dark turn, hitting a new low, while Nathan West delivers shocking news. Events remain in high gear in Port Charles, as Brook Lynn Quartermaine (Amanda Setton) departs on a private jet amid concerns about Tracy Quartermaine's (Jane Elliot) whereabouts.

Spoilers for General Hospital look for Felicia Scorpio (Kristina Wagner) to express her fears about James West's (Gary James Fuller) well-being, given Maxie Jones's (Kirsten Storms) coma and the return of his absentee father. Nina Reeves (Cynthia Watros) is taken aback by Nathan's unexpected return from the dead, and the fallout from Curtis Ashford (Donnell Turner) and Portia Robinson's (Brook Kerr) marital breakdown continues. 

General Hospital spoilers look at the suspicions around Drew's shooting intensify, Portia may find herself in the crosshairs. A surprise visitor at Monica Quartermaine's (Leslie Charleson) memorial service stirs up emotions, with Erika Slezak's character, Ronnie, claiming to be Monica's sister. As the PCPD investigates a judge's murder and Drew's shooting, Drew plots against Michael Corinthos (Rory Gibson). The week wraps up with shocking revelations about Nathan's past seven years and a heated dispute over the Quartermaine estate the week of 9/29 - 10/03/2025.  

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