Normal 5.6-7.5 % of total Hgb

Indications

• Assess control of blood sugars over a several month time frame
• Diagnose Diabetes Mellitus (DM)

Description

Glycosylated Hemoglobin (HbA1c) is the combination of glucose and hemoglobin. When glucose is elevated in the blood the amount of glycosylated hemoglobin increases proportionally. A red blood cells lifespan is about 4 months, so you can get an idea of blood sugar control over the last several months.

What would cause increased levels?

• Poorly controlled Diabetes Mellitus(DM)
• Non-Diabetic Hyperglycemia:
  • Stress
  • Cushing Syndrome
  • Pheochromocytoma
  • Corticosteroid Therapy

What would cause decreased levels?

• Renal failure
• Blood loss
• Hemolytic anemia
• Sickle cell anemia