Healthy Dialogue

It's been unclear whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is an effective treatment for acute stroke. JAMA Deputy Editor Chris Muth, MD, speaks with author Rolf Blauenfeldt, MD, Aarhus University Hospital, Denmark, about the RESIST randomized clinical trial, which looks at the effect of RIC when initiated in the prehospital setting. Related Content:

• Remote Ischemic Conditioning for Acute Stroke

During the COVID-19 pandemic, the incidence of diabetes in childhood increased. JAMA Associate Editor Anne R. Cappola, MD, ScM, and Ezio Bonifacio, PhD, from the Center for Regenerative Therapies at the Dresden University of Technology, discuss SARS-CoV-2 infection and its association with islet autoimmunity in early childhood. Related Content:

• SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood

Many premature infants with respiratory distress are now supported with continuous positive airway pressure, or CPAP, rather than intubation and ventilation, and those with CPAP can receive surfactant via a minimally invasive approach. JAMA Associate Editor Tracy Lieu, MD, speaks with author Peter Dargaville, MD, from the Menzies Institute for Medical Research in Tasmania, Australia, about Two-Year Outcomes After Minimally Invasive Surfactant Therapy in Preterm Infants: Follow-Up of the OPTIMIST-A Randomized Clinical Trial. Related Content:

• Two-Year Outcomes After Minimally Invasive Surfactant Therapy in Preterm Infants

There is an established link between sedentary behavior and cardiovascular disease, but the association between sedentary behavior and dementia is unclear. JAMA Deputy Editor Christopher C. Muth, MD, speaks with David A. Raichlen, PhD, University of Southern California, about a new study that investigates the relationship between sedentary behavior and dementia in older adults. Related Content:

• Sedentary Behavior and Incident Dementia Among Older Adults

In a new study, psilocybin showed promise as a treatment for major depressive disorder (MDD). JAMA Associate Editor Donald C. Goff, MD, speaks with author Charles L. Raison, MD, from the Usona Institute, about the study, as well as Rachel Yehuda, PhD, Mount Sinai School of Medicine, who wrote an accompanying editorial about the potential benefits of psychedelic therapies. Related Content:

• Single-Dose Psilocybin Treatment for Major Depressive Disorder
• Psychedelic Therapy—A New Paradigm of Care for Mental Health

Magnesium sulfate is widely recommended for neuroprotection in pregnancies at risk of preterm delivery. However, the optimal gestational age for use is unclear. JAMA Associate Editor Melissa Simon, MD, MPH, and Caroline Crowther, MD, Liggins Institute, University of Auckland, discuss the use of magnesium sulfate at different gestational ages and potential benefit vs harms as reflected in the MAGENTA Trial. Related Content:

• Prenatal Intravenous Magnesium at 30-34 Weeks' Gestation and Neurodevelopmental Outcomes in Offspring

Anthracyclines are used to treat a variety of cancers, but treatment may be limited by cardiac toxicity. JAMA Executive Editor Gregory Curfman, MD, discusses a new clinical trial on the use of atorvastatin to prevent anthracycline-induced cardiac toxicity with authors Tomas Neilan, MD, MPH, and Marielle Scherrer-Crosbie, MD, PhD. Related Content:

• Atorvastatin for Anthracycline-Associated Cardiac Dysfunction

Cardiovascular health is essential to everyone, but especially important to address in individuals who can become or who are pregnant or postpartum. JAMA Associate Editor Melissa Simon, MD, MPH, and Sadiya S. Khan, MD, MSc, Northwestern University, discuss the importance of cardiovascular health in pregnancy-capable, pregnant, and postpartum persons, how to counsel such individuals, issues of access to care and health equity, and their impact on cardiovascular health. Related Content:

• Trends in Cardiovascular Health Counseling Among Postpartum Individuals

Bempedoic acid is an effective option for some statin-intolerant patients with an elevated predicted risk of cardiovascular events. However, as JAMA Executive Editor Gregory Curfman, MD, discusses with editorialist Dhruv S. Kazi, MD, MSc, MS, bempedoic acid should not be considered a substitute for statins, which remain the first-line therapy for primary prevention. Related Content:

• Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients
• Bempedoic Acid for High-Risk Primary Prevention of Cardiovascular Disease

The performance of whole-genome sequencing in comparison with targeted genomic testing methods is not well understood. In this podcast, JAMA Associate Editor W. Gregory Feero, MD, PHD, interviews author Jill L. Maron, MD, MPH, of the Women and Infants Hospital of Rhode Island about a study of whole-genome sequencing vs a commercially available targeted genetic testing platform for diagnosing ill neonates with suspected genetic conditions. Related Content:

• Rapid Whole-Genomic Sequencing and a Targeted Neonatal Gene Panel in Infants With a Suspected Genetic Disorder