AI is reshaping clinical care, but can we apply trusted bioethical principles to its rapid adoption? This discussion explores how the Belmont Report’s three ethical pillars - autonomy, beneficence, and justice - remain essential as AI tools enter diagnosis, decision-making, and patient communication in modern healthcare. Hosted by Mika Newton, CEO of xCures, with expert insights from Dr. Colleen Lyons, a leading clinical research ethicist, the discussion covers informed consent in AI-assisted care, transparency versus explainability, and the ethical implications of asymmetrical power in AI systems. Gain a deeper understanding of how healthcare leaders can navigate AI integration while safeguarding patient rights and institutional trust.