Acute elevations in intracranial pressure from brain injury or illness can be life-threatening or lead to significant morbidity. Rapid identification and lowering of the intracranial pressure with directed therapy in the form of hyperosmolar therapy while awaiting definitive management of the underlying cause is essential in many cases. This podcast will discuss the selection between mannitol and hypertonic saline, logistics of storage and administration in the emergency department, goals of therapy, and monitoring parameters.  

The information presented during the podcast reflects solely the opinions of the presenter. The information and materials are not, and are not intended as, a comprehensive source of drug information on this topic. The contents of the podcast have not been reviewed by ASHP, and should neither be interpreted as the official policies of ASHP, nor an endorsement of any product(s), nor should they be considered as a substitute for the professional judgment of the pharmacist or physician.