Sean's shingles shot leaves him sickly but safeguarded. Priyanka struggles with staying serene. Leslie Jordan shares his story about growing up gay in the South and his stirring journey with sobriety.

Dr. Wali discusses the importance of dancing like no one is watching. Sean makes a "rash" decision. Scott Wolf and Dr. Wali compare notes about playing doctor. Scott reveals the impact of not taking his laxatives.

Sean's colonoscopy saga comes to an end and his test results are revealed. A listener calls in with another bug story. Margaret Cho talks confidence in comedy. And Dr. Wali digs deep into Margaret's plantar warts.

Dr. Wali and Sean reveal their morning routines. Robert Downey Jr. shares his love for Wing Chun Kung Fu and his thoughts on Iron Man’s final words. And Dr. Wali uncovers the truth about Robert’s “Cat Scratch Fever.”

Sean and Dr. Wali talk about travel comfort items. Debra Messing breathes through her story about bronchitis and how she quit smoking. Sean and Debra reminisce about their time on Will & Grace and talk about what it takes to perform on Broadway eight times a week.

Sean goes deep to update Dr. Wali on how his colonoscopy went. Then they confront the importance of being honest in therapy. Chelsea Handler rhapsodizes about her love of cannabis and her experience with ayahuasca.

Sean covers both ends by mentally preparing for his upcoming colonoscopy. Sean and Dr. Wali talk about the human experience through time. A listener calls in about being born without a butthole. Margo Martindale bends over backwards to share her scoliosis story.

Sean and Dr. Wali talk about discrimination in medicine and music that has had a deep impact in their lives. Tony Hale takes a deep breath and talks about his experience with asthma.

Sean faces the music over his tendonitis from playing the piano and delves deeply into stress over his upcoming colonoscopy. Wendie Malick talks about managing her arthritis and breaking her ankle motorcycling in Africa.

Sean’s A-Fib acts up again so he has to sneak out of a party to rush to the hospital. Priyanka explains trauma therapy with EMDR and Brainspotting. Tony Goldwyn shares his scary parent story when his 18 month old daughter needed a tonsillectomy.